Clinical trials: Acute Exacerbation of Chronic Obstructive Pulmonary Disease
COPD, Non Invasive Ventilation (NIV)
Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Non-invasive ventilation (NIV) is an evidence-based treatment for patients with acute respiratory failure due to an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- COPD, Non Invasive Ventilation (NIV), VOX Index
- Trial name
- NCT07074210
- Testing
- non invasive ventilation
- Volunteers
- 190 people
- Sponsor
- Assiut University
COPD Exacerbation
Acupuncture Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Chronic obstructive pulmonary disease (COPD) is a major health problem. Acute exacerbations are a health-care burden involving frequent hospitalizations and elevated costs.
- Trial name
- NCT03398213
- Testing
- Acupuncture
- Where
- 2 sites in Israel
- Volunteers
- 72 people
- Sponsor
- Bnai Zion Medical Center
COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation
A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD
The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate chronic obstructive pulmonary disease (COPD)
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation, COPD Exacerbation Acute
- Trial name
- R-3750-01-LU (NCT07076290)
- Testing
- R-3750
- Volunteers
- 27 people
- Sponsor
- Rise Therapeutics LLC
Pulmonary Disease, Chronic Obstructive
Task-specific Training for Patients With Acute Exacerbation of COPD
Patients with Chronic Obstructive Pulmonary Disease (COPD) experience a progressive deterioration in their quality of life. Task-specific training is a type of approach focused on chronic patients that allows the acquisition of…
- Trial name
- COPD (NCT06224075)
- Testing
- Task-specific training, Usual care
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Universidad de Granada
COPD Exacerbation Acute
COPD-ICU Multicentre Prospective Observational Register
COPD is one of the leading causes of morbidity, mortality and health care utilisation worldwide. Currently, COPD is the third leading cause of death worldwide and is therefore a major public health problem.
- Trial name
- COPD-ICU (NCT05734365)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Versailles Hospital
Chronic Obstructive Pulmonary Disease
A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD
COPD is a condition which affects over 3 million people in the UK. It causes chronic symptoms including breathlessness and cough, limitations in exercise tolerance and acute exacerbations of COPD (AECOPD) which often lead to…
- Trial name
- PROPEL myCOPD (NCT05835492)
- Testing
- myCOPD
- Where
- 3 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- my mhealth Ltd
COPD Exacerbation Acute
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compared to that in patients in…
- Trial name
- COPD (NCT04879030)
- Testing
- Beta-Lactams, Fluoroquinolone
- Where
- Vietnam
- Volunteers
- 170 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
COPD Exacerbation, ICU
Characteristics and Outcomes of Patients Admitted to ICU for a Severe Acute Exacerbation of COPD.
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different…
- Trial name
- COPDregister (NCT06257329)
- Testing
- register
- Where
- 4 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Alexis FERRE
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
Chronic Obstructive Pulmonary Disease Exacerbation
The CATALINA Study
The CATALINA study is a prospective cohort study embedded within CICERO (Collaboration In COPD ExaceRbatiOns, a European Respiratory Society supported Clinical Research Collaboration), designed to collect standardised…
- Trial name
- NCT05008081
- Where
- 22 sites in Austria, Belgium and 9 more
- Volunteers
- 1,000 people
- Sponsor
- Wim Janssens
Chronic Obstructive Pulmonary Disease, Acute Respiratory Failure
Protocol Chronic Obstructive Pulmonary Disease
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD.
- Trial name
- NCT00404430
- Where
- France
- Volunteers
- 121 people
- Sponsor
- University Hospital, Grenoble
COPD
Ultrasound of the Diaphragm Excursion Ratio as Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
3.1 Introduction and rationale In 2020 an estimate of 562.700 people had Chronic Obstructive Pulmonary Disease (COPD) in the Netherlands, resulting in 21.335 hospital admissions.[1] An acute exacerbation COPD (AECOPD) in…
- Trial name
- Undated 2 (NCT07259174)
- Where
- 2 sites in Netherlands
- Volunteers
- 186 people
- Sponsor
- Isala
COPD Exacerbation
Extracorporeal Carbon Dioxide Removal in Severe Chronic Obstructive Pulmonary Disease Exacerbation
The conventional treatment for Severe acute exacerbation of Chronic obstructive pulmonary disease including noninvasive respiratory support, invasive respiratory support, etc, but there are many kinds of limitations and…
- Trial name
- NCT03692117
- Testing
- Extracorporeal Carbon Dioxide Removal
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Disease, Chronic Obstructive
Effects of Tai Chi for Early Pulmonary Rehabilitation in Elderly Patients With AECOPD
The goal of this clinical trial is to learn about the therapeutic effect of Chinese traditional exercise Tai Chi in elderly acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with malnutrition.
- Trial name
- NCT05986448
- Testing
- Tai-chi exercise
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Houmei SHEN
COPD Exacerbation Acute
CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide.
- Trial name
- AECOPD (NCT06514599)
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Chronic Obstructive Pulmonary Disease
Effects of Traditional Chinese Medicine on Outcomes in Patients With AECOPD Risk Window
This study aims to objectively evaluate the clinical efficacy and safety of Traditional Chinese Medicine in the treatment of AECOPD Risk Window, providing a basis for the formulation of TCM treatment plan with AECOPD.
- Trial name
- NCT04851093
- Testing
- TCM granule plus conventional drug
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Acute Exacerbation Copd, Venous Thromboembolism
Study of Prophylactic Effect of Rivaroxaban on Venous Thromboembolism in AECOPD
AECOPD increases the risk of VTE.VTE prevention is a long way to go for high-risk VTE patients in China.The incidence of AECOPD complicated with VTE in Asian population is high and the mortality rate is high.Rivaroxaban, a new…
- Trial name
- SUPREME (NCT03277001)
- Testing
- Rivaroxaban, Enoxaparin
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Huashan Hospital
COPD
Exacerbation and Training in Patients With Chronic Obstructive Pulmonary Disease
When patients with chronic obstructive lung disease (COPD) are admitted to the hospital with a severe exacerbation they lose muscle strength. This muscle weakness predisposes these patients to further hospital admissions.
- Trial name
- EXTRA (NCT00877084)
- Testing
- Resistance training, Usual care
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Pharyngitis, Acute Tonsillitis
Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies
The general hypothesis is that delayed antibiotic treatment strategies present similar effectiveness, when compared with non-prescription of antibiotics or the prescription of antibiotics, in the non-complicated acute respiratory…
- Conditions
- Pharyngitis, Acute Tonsillitis, Rhinosinusitis, Acute Bronchitis
- Trial name
- PDA (NCT01363531)
- Testing
- Antibiotic prescription strategies
- Where
- Spain
- Volunteers
- 405 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
COPD Exacerbation Acute
Tolerance and Acute Effects of a New HFNT Nasal Cannula
In the care of patients experiencing an acute exacerbation of COPD, supplemental oxygen therapy is often required. Oxygen is typically administered at flow rates between 1 and 4 liters per minute.
- Trial name
- NCT05182294
- Testing
- AIRVO 2, the new asymmetric nasal cannula
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Temple University