Clinical trials: Acute Exacerbations of COPD
Pulmonary Disease, Chronic Obstructive
Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 1
A randomized, placebo-controlled, double-blind, parallel group, multi center study to assess the safety and efficacy of tiotropium bromide (18 µg) delivered via the HandiHaler® in Chronic Obstructive Pulmonary Disease (COPD)…
- Trial name
- NCT01663987
- Testing
- tiotropium bromide
- Where
- 50 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- Boehringer Ingelheim
COPD, Heart Failure
Implementation of Telemonitoring in Chronic Heart or Lung Failure
The aims of the study are to: 1. Implement a telemonitoring programme in heart failure and obstructive pulmonary disease (COPD) /chronic respiratory patients by assessing the real world impact of on readmissions, consults, home…
- Conditions
- COPD, Heart Failure, Respiratory Failure
- Trial name
- TELECRAFT (NCT02180919)
- Testing
- CE marked Philips Motiva system
- Where
- 2 sites in United Kingdom
- Volunteers
- 85 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD Exacerbation
Biomarker of Acute Exacerbation of COPD
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease.
- Trial name
- NCT04963244
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disease characterized by persistent airflow limitation and enhanced oxidative stress.
- Trial name
- NCT07456176
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablets, Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Hyperglycemia
Insulin Therapy in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The purpose of this study is to determine the effect of preventing hyperglycaemia in patients admitted to hospital with acute exacerbations of chronic pulmonary disease.
- Trial name
- NCT00467636
- Testing
- Blood glucose monitoring, Insulin Glulisine
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- The Royal Bournemouth Hospital
Chronic Obstructive Pulmonary Disease
N-acetylcysteine (NAC) for the Treatment of Acute Exacerbation of COPD
Patients with Chronic obstructive pulmonary disease (COPD) experience gradually deteriorating lung function, which may be complicated by acute exacerbations.
- Trial name
- NCT05706402
- Testing
- N-acetylcysteine
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Chronic Obstructive Pulmonary Disease
Home High Flow Oxygen to Reduce Acute Exacerbation of COPD
The objective of the study is to evaluate the efficacy of home High Flow Oxygen for the reduction of severe exacerbation following admission for a severe exacerbation of COPD or death against standard oxygen therapy.
- Trial name
- HIFAE (NCT05196698)
- Testing
- High Flow Oxygen Therapy, Long-term oxygen therapy
- Where
- France
- Volunteers
- 406 people
- Sponsor
- University Hospital, Rouen
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Impact of HI-NPPV Vs LI-NPPV on Tolerance Among AECOPD Patients
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could have an effect on the subjective tolerance in patients with an AECOPD and hypercapnia.
- Trial name
- NCT06692023
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
This is a study to evaluate the effects of early pulmonary rehabilitation within 10 days after discharge from the hospital after a COPD exacerbation on exercise tolerance, exacerbations, re-admissions and the quality of life…
- Trial name
- NCT00413543
- Testing
- early pulmonary lung rehabilitation
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Isala
COPD, COPD Exacerbation Acute
Multiparametric Home Telemonitoring of Patients With Chronic Obstructive Pulmonary Disease Exacerbation
Chronic obstructive pulmonary disease (COPD) exacerbations are risk factors for disease progression and short-term re- hospitalizations.
- Trial name
- NCT06331416
- Testing
- Telemonitoring
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Trieste
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Effectiveness and Feasibility of Delivering an Education Program to Patients With an Acute Exacerbation of COPD
The purpose of this study is to determine if it is effective and feasible to provide a chronic obstructive pulmonary disease (COPD) education program to patients admitted with an acute exacerbation of COPD.
- Trial name
- NCT02321215
- Testing
- Introductory Disease Education
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- West Park Healthcare Centre
Chronic Obstructive Pulmonary Disease, Sepsis
Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation
Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sepsis, Antibiotics
- Trial name
- NCT00791505
- Testing
- ciprofloxacin, trimethoprim-sulfamethoxazole
- Volunteers
- 170 people
- Sponsor
- University of Monastir
COPD Exacerbation
Evaluation of the Efficacy of Different Nebulization Techniques
COPD is the 3rd most common cause of death in the world, and the most common places of admission in our country with exacerbation of COPD are emergency services.
- Trial name
- NCT05507060
- Testing
- Vibrating MESH nebulizer (Aerogen Ultra), Jet nebulizers (Philips Respironics)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Copd
Sonographic Diaphragm Function in AECOPD
The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea…
- Trial name
- UNDATED (NCT05671198)
- Testing
- Ultrasound of the diaphragm
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Isala
COPD Exacerbation, Enoximone
The Effects of Enoximone in Acute Exacerbation COPD
Introduction: The pharmacodynamic properties of enoximone could be beneficial for patients with an Acute Exacerbation COPD (AE-COPD).
- Conditions
- COPD Exacerbation, Enoximone, Phosphodiesterase Inhibitor
- Trial name
- NCT04420455
- Testing
- Enoximone
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Rijnstate Hospital
Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation.
- Trial name
- NCT04640948
- Testing
- High flow nasal therapy, Low flow oxygen
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Belfast Health and Social Care Trust
COPD Exacerbation Acute
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compared to that in patients in…
- Trial name
- COPD (NCT04879030)
- Testing
- Beta-Lactams, Fluoroquinolone
- Where
- Vietnam
- Volunteers
- 170 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
COPD
EMG in COPD - Factor Analysis
Acute exacerbations of COPD contribute to significant morbidity and mortality in the United Kingdom (UK). The ability to assess response to treatment during exacerbations that require hospitalisation would allow clinicians to…
- Trial name
- EMGCOPD (NCT02721199)
- Testing
- Neural Respiratory Drive Automated EMGpara assessment
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation
Muscle Oxygenation in Chronic Obstructive Pulmonary Disease
The aim of our study is to examine the Peripheral Muscle Oxygenations at rest and in motion on the 2nd day of hospitalized patients and before discharge in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease and to…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation, Muscle Oxygenation
- Trial name
- NCT05808621
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Bandırma Onyedi Eylül University