Clinical trials: Acute Gastrointestinal Injury
Acute Pancreatitis (AP)
ENDoscopic Assessment in Acute PANcreatitis Study (ENDOPAN Study)
This is a prospective observational cohort study designed to evaluate early upper gastrointestinal endoscopic findings in adult patients hospitalized with acute pancreatitis.
- Trial name
- NCT07714850
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jan Kochanowski University
Gastroparesis, Hip Fracture
Gastric Emptying in Elderly With Hip Fracture
The gastric emptying of 400 ml 12.6% carbohydrate rich drink is investigated in elderly women, age 75-100, with acute hip fracture.
- Conditions
- Gastroparesis, Hip Fracture, Mild Insufficient Nutrition
- Trial name
- GASEMPHIP (NCT02753010)
- Testing
- Gastric emptying of carbohydrate-rich beverage
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acute Cholecystitis
Different Timing for Early Laparoscopic Cholecystectomy in Acute Calcular Cholecystitis
The ideal timing for ELC continues to be debatable in patients with acute calculator cholecystitis (ACC). This study was planned to identify the impact of different ELC timing in ACC on surgical outcomes in terms of safety and…
- Trial name
- ACC (NCT04405713)
- Testing
- from the onset of symptoms within the first 3 days, : from the onset of symptoms within the 4-7 days, from the onset of symptoms beyond 7 days
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Mansoura University
Radiotherapy; Complications, Cardiotoxicity
Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity…
- Conditions
- Radiotherapy; Complications, Cardiotoxicity, Cancer, Lung Cancer
- Trial name
- NCT04896242
- Where
- Chile
- Volunteers
- 47 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Kidney Injury, Liver Diseases
Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
Acute kidney injury (AKI) following liver transplantation (LT) is associated with increased costs, morbidity, and mortality. Dexmedetomidine has known to have anti-inflammatory effect and has been shown to ameliorate IRI in…
- Trial name
- NCT03522688
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Asan Medical Center
Acute Liver Failure, Acute Liver Injury
Biomarkers in Liver Failure
Acute liver injury (ALI) and acute liver failure (ALF) are rare clinical conditions, the latter often associated with a poor outcome.
- Conditions
- Acute Liver Failure, Acute Liver Injury, Acute on Chronic Hepatic Failure
- Trial name
- NCT02833064
- Testing
- Non-contrast magnetic resonance imaging, Biological sampling
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Gastrointestinal Injury, Gastrointestinal Hemorrhage
Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
- Conditions
- Gastrointestinal Injury, Gastrointestinal Hemorrhage, Gastrointestinal Lesions, Gastrointestinal Ulcer
- Trial name
- GESEMM (NCT05226221)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Campus Bio-Medico University
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Gastrointestinal Disease
The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block
In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute…
- Trial name
- NCT04934904
- Testing
- Ropivacaine injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Cholecystitis, Acute Cholecystitis
Fundus-first Laparoscopic Cholecystectomy
Bile duct injury (BDI) remains the most feared complication of laparoscopic cholecystectomy, particularly in difficult gallbladder cases.
- Conditions
- Cholecystitis, Acute Cholecystitis, Pericholecystic Abscess
- Trial name
- FFLC (NCT07137546)
- Testing
- Fundus-First Laparoscopic Cholecystectomy ( FFLC), Classical Laparoscopic Cholecystectomy (CLC)
- Where
- Egypt
- Volunteers
- 174 people
- Sponsor
- Minia University
Drug-Induced Acute Liver Injury
Bicyclol in the Treatment of Antineoplastic Drug-induced Liver Injury.
The clinical trial is designed to evaluate the efficacy of bicyclol for patients with antineoplastic drug-induced liver injury and investigate factors effecting the therapeutic outcome.
- Trial name
- NCT05711459
- Testing
- Bicyclol tablets
- Where
- China
- Volunteers
- 5,405 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hepato-Renal Syndrome, Portal Hypertension
MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)
Heptorenal syndrome (HRS) is divided into two types. A non-acute kidney injury (NAKI-HRS), which is predominantly related to end-stage disease and a more acute kidney injury (HRS-AKI).
- Conditions
- Hepato-Renal Syndrome, Portal Hypertension, Acute Kidney Injury, Liver Diseases
- Trial name
- NCT03483272
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury
Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation
Hepatorenal Syndrome (HRS) is a serious complication that can occur in patients with liver cirrhosis, characterised by kidney dysfunction, or acute kidney failure (AKI).
- Conditions
- Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury, Liver Transplant
- Trial name
- NCT07300709
- Testing
- renal biopsy
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The University of Hong Kong
Gastrointestinal Hemorrhage, Liver Cirrhosis
Optimal Clinical Predictors to AKI in Cirrhotic Patients Experienced Acute Gastrointestinal Hemorrhage
Acute kidney injury (AKI) is a common complication, occurring in approximately 20% of hospitalized cirrhotic patients and has a significant negative impact on patients' outcomes according to either the initial stage (at the time…
- Conditions
- Gastrointestinal Hemorrhage, Liver Cirrhosis, Acute Kidney Injury
- Trial name
- ABC(AKI-B) (NCT04184934)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gallstone, Gallstone; Cholecystitis, Acute
Indocyanine Green Fluorescence During Fundus First Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is the routine method for managing gallstone disease. This is considered a safe procedure with low risk of severe complications.
- Trial name
- INFUNDUS (NCT06918210)
- Testing
- Indocyanine Green, Cholangiography
- Volunteers
- 294 people
- Sponsor
- Karolinska Institutet
Cystic Fibrosis
Prospective Observational Study to Evaluate Biomarkers of Aminoglycoside Nephrotoxicity in Patients With Cystic Fibrosis
The project is designed to test new biomarkers that are more sensitive than the current standard in detecting injury to the proximal kidney tubule and will establish better criteria for when kidney safety concerns may halt…
- Trial name
- NCT01543620
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Foundation for the National Institutes of Health
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Liver Cirrhosis
Sustained Low Efficiency Dialysis Versus Continuous Renal Replacement Therapy for Acute Kidney Injury in Critically Ill Cirrhotics
The current prospective pliot randomized controlled trial has been designed to demonstrate non-inferiority of sustained low efficiency dialysis (SLED) when compared to continuous renal replacement therapy in managing AKI in…
- Trial name
- NCT04494542
- Testing
- Sustained Low Efficiency Dialysis (SLED), Continuous Renal Replacement Therapy
- Where
- India
- Volunteers
- 62 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Rectal Cancer, Gastric Cancer
The Effect of Bone Marrow-sparing Intensity-Modulated Radiotherapy to GI Cancer
Concurrent chemotherapy with external beam radiotherapy is the standard treatment of bulky or locally advanced cervical cancer, gastric cancer and rectal cancer.Despite excellent therapeutic results, acute hematologic toxicity…
- Conditions
- Rectal Cancer, Gastric Cancer, Bone Marrow Toxicity, Adverse Effect of Radiation Therapy
- Trial name
- IMRT (NCT01863420)
- Testing
- Bone Marrow-sparing Intensity-Modulated Radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Chinese Academy of Medical Sciences