Clinical trials: Acute Gastrointestinal Injury
Anemia
Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO
The investigators seek to determine whether providing inhaled nitric oxide (iNO; a vasodilator) will improve the delivery of oxygen to the brain, kidney and intestines of preterm neonates during and after the subject receives a…
- Trial name
- iNO-TRAGI (NCT02851472)
- Testing
- Inhaled Nitric Oxide
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- New York Medical College
Acute Gastrointestinal Injury, Critical Illness
Correlation Between Acute Gastrointestinal Injury and Venous Return in Critical Ill Patients
Currently, altered intestinal blood flow in critically ill patients has been a hot research topic in recent years. In 2022, studies on acute mesenteric ischemia were published in top journals in critical care medicine [Crit Care…
- Trial name
- NCT06667297
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Ischemia, Fatty Acid-Binding Proteins
Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair
This study aims to investigate the predictive value of novel biomarkers and contrast-enhanced ultrasonography for early detection of abdominal end-organ (kidney and intestinum) hypoperfusion and ischemia in patients undergoing…
- Conditions
- Ischemia, Fatty Acid-Binding Proteins, Mesenteric Vascular Disease, Acute Kidney Injury
- Trial name
- KISMED (NCT01915446)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Regensburg
Gastrointestinal Dysfunction, Critical Illness
Association Between SMA Flow and AGI in Critically Ill Patients
Acute gastrointestinal injury (AGI) is related to poor outcomes of critically ill patients [1] through many underlying mechanisms [2]. It is also a part of the process of multiple organ dysfunction syndrome (MODS).
- Trial name
- NCT04979494
- Testing
- ultrasound examination
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Xinchen Wang
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Cirrhosis, Liver, End Stage Liver DIsease
Angiotensin 2 for AKI After OLT
Kidney injury is a common complication following liver transplantation and is associated with a higher complication rate and increased risk of death.
- Conditions
- Cirrhosis, Liver, End Stage Liver DIsease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- NCT04592744
- Testing
- Angiotensin II, Norepinephrine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Heart Valve Diseases
Prolonged Cardiopulmonary Bypass Time as a Predictive Factor for AGI After Heart Valve Replacement
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
- Trial name
- NCT05498935
- Testing
- CPB time
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Acute Kidney Injury, Acute-On-Chronic Liver Failure
Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF).
- Trial name
- NCT04525625
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Institutul Clinic Fundeni
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hepatic Failure, Liver Transplant
Perioperative Use of Amino Acids in Recipients of Orthotopic Liver Transplantation as a Renal Protective Factor
Orthotopic liver transplantation is the definitive treatment for end-stage liver failure, with renal failure being an important complication of this procedure that has implications for long- and short-term prognosis, affecting…
- Conditions
- Hepatic Failure, Liver Transplant, Renal Failure, Acute
- Trial name
- PAATHO (NCT07004387)
- Testing
- Amino acid solution, Amino Acid infusion
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Hospital Dr Sotero del Rio
Acute Appendicitis, Surgical Site Infection
Are Double-ring Wound-edge Protectors Effective for Preventing Superficial Surgical Site Infection After Open Appendectomy?
This study aims to evaluate the utility of double-ring wound-edge protectors to prevent the development of superficial surgical site infections after open appendectomy.
- Trial name
- sSSI-2RWEPs (NCT04860570)
- Testing
- Double-ring wound-edge protector
- Where
- Spain
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- Hospital Medina del Campo
Cystic Fibrosis
Renal Failure Following Lung Transplantation in Cystic Fibrosis Patients
With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with…
- Trial name
- AKI_LUTX (NCT05001841)
- Testing
- Lung Transplantation
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Policlinico Hospital
Acute Kidney Injury, Cancer Colorectal
Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of…
- Trial name
- PROSACC (NCT05585866)
- Testing
- Anesthesia Agent
- Where
- Sweden
- Volunteers
- 4,000 people
- Sponsor
- Uppsala University
Graves Disease, Graves Ophthalmopathy
Liver Function After Intravenous Methylprednisolone Administration
Graves' orbitopathy (GO) is a characterized by orbital soft tissue inflammation and oedema associated with glycosaminoglycan deposition and fibrosis. The most frequent cause is Graves' disease.
- Conditions
- Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure
- Trial name
- NCT03667157
- Testing
- every week IVMP therapy, very high doses IVMP therapy
- Volunteers
- 68 people
- Sponsor
- Medical University of Warsaw
Bowel Obstruction
Emergency General Surgery for Non-trauma
This study will observe the postoperative morbidity and mortality trends in patients with non- traumatic abdominal pathology who will undergo emergency general surgery.
- Trial name
- NCT04539028
- Testing
- Emergency Abdominal surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York Medical College
Hepatorenal Syndrome
Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndrome
Hepatorenal syndrome is a serious complication of advanced liver disease in which kidney function rapidly worsens and can lead to life-threatening illness.
- Trial name
- NCT07460908
- Testing
- terlipressin, Octreotide (drug)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Myocardial Infarction, Death
Prognostic Impact of Organ Damage in STEMI Patients
Besides contrast-induced acute kidney injury (CI-AKI), adscititious vital organ damage such as hypoxic liver injury (HLI) may affect the survival in patients with ST-elevation myocardial infarction (STEMI).
- Conditions
- Myocardial Infarction, Death, Acute Kidney Injury, Hepatic Insufficiency
- Trial name
- NCT02800421
- Volunteers
- 668 people
- Sponsor
- Inha University Hospital
Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury
Digoxin In Treatment of Alcohol Associated Hepatitis
Prospective, single center, open label, randomized controlled trial to explore whether digoxin treatment affects cytokine levels as biomarkers of inflammation in patients with acute alcohol associated hepatitis, digoxin…
- Conditions
- Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury, Alcohol-Induced Disorders, Steatohepatitis Caused by Ingestible Alcohol
- Trial name
- DIGIT-AlcHep (NCT05014087)
- Testing
- Intravenous digoxin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Hepatocellular Carcinoma, Hepatoma
Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery
It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). Sevoflurane may increase the risk for postoperative AKI because of production of compound-A.
- Conditions
- Hepatocellular Carcinoma, Hepatoma, Cholangiocarcinoma, Gallbladder Neoplasms
- Trial name
- NCT02174575
- Testing
- Sevoflurane, Desflurane
- Where
- Japan
- Sponsor
- Tokyo Medical and Dental University