Clinical trials: Acute Graft-versus-host Disease
Myocardial Infarction, ST Elevation Myocardial Infarction
Early Discharge Pathway Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT06040528
- Where
- 2 sites in United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Stroke, Cerebrovascular Accident
Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
The purpose of this study is to determine whether a non-painful, non-invasive, brain-stimulation technique called transcranial direct current stimulation (tDCS) combined with traditional physical-occupational therapy (OT) will…
- Conditions
- Stroke, Cerebrovascular Accident, CVA, Acute Stroke
- Trial name
- TDCS+OT (NCT00792428)
- Testing
- Real Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Myelogenous Leukemia
Vaccination in the Peripheral Stem Cell Transplant Setting for Acute Myelogenous Leukemia
The purpose of this study is to evaluate clinical and laboratory safety associated with the administration of GVAX leukemia vaccine and to determine the feasibility of generation of GVAX leukemia vaccine in subjects with acute…
- Trial name
- NCT00116467
- Testing
- GVAX leukemia vaccine (therapeutic cellular vaccine, GM-CSF producing)
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- Cell Genesys
Stroke, Acute, Cerebrovascular Disorders
The Norwegian Tenecteplase Stroke Trial 2
Background: Alteplase is the only approved acute drug treatment in ischemic stroke and aims at dissolving arterial clots causing cerebral ischemia. The overall benefit of alteplase is substantial.
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Ischemic Stroke
- Trial name
- NOR-TEST 2 (NCT03854500)
- Testing
- Tenecteplase, Alteplase
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Haukeland University Hospital
Opioid Consumption, Demographic Data
Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB)
Breast cancer is the most common malignancy in women; one of the mainstays of breast cancer treatment is surgery, and modified radical mastectomy is one of the standard treatments.
- Trial name
- NCT06751407
- Testing
- Single level SPSIPB, Two-level SPSIPB
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Study of IMM01 Combined With Azacitidine in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome
This trial is an open-lable , multi-center, Phase 1/Phase 2 study that will evaluate the safety, tolerability, Pharmacokinetics, Pharmacodynamics and and immunogenicity of IMM01 combined with Azacitidine in patients with Acute…
- Trial name
- NCT05140811
- Testing
- IMM01, Azacitidine
- Where
- 22 sites in China
- Volunteers
- 126 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Leukemia, Myeloid, Leukemia
Assessing PI3K Gamma Inhibition With Azacitidine, Venetoclax and Eganelisib in Patients With Acute Myeloid Leukemia
This study is to evaluate the safety and preliminary efficacy of adding the PI3K-gamma inhibitor, eganelisib, to a standard of care treatment option with combination venetoclax and azacitidine in participants with acute myeloid…
- Conditions
- Leukemia, Myeloid, Leukemia, Acute Myeloid Leukemia, Refractory Leukemia
- Trial name
- GAVEL (NCT07439211)
- Testing
- Eganelisib, Azacitidine, Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Jacqueline Garcia, MD
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Migraine Headache
Study in Participants With Acute Migraines Headaches
This is a Phase 2, multicenter, randomized, double-blind, placebo and active comparator-controlled study of LY2590443 in approximately 200 participants with migraines.
- Trial name
- NCT00804973
- Testing
- LY2590443, Sumatriptan
- Where
- 19 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pain, Ketamine Adverse Reaction
Cardiovascular Safety After Continuous Ketamine Infusion
Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain
- Conditions
- Pain, Ketamine Adverse Reaction, Postoperative Pain
- Trial name
- NCT03979105
- Testing
- Ketamine
- Where
- 2 sites in Colombia
- Volunteers
- 300 people
- Sponsor
- Universidad de Antioquia
Acute Respiratory Distress Syndrome, Severe Pneumonia
One Year Follow-ups of Patients Admitted to Spanish Intensive Care Units Due to COVID-19
The latest epidemiological data published from Chine reports that up to 30% of hospital-admitted patients required admission to intensive care units (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Severe Pneumonia, Respiratory Failure
- Trial name
- NCT04457505
- Where
- 31 sites in Spain
- Volunteers
- 8,500 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Breast Milk Collection, Overweight and Obesity
Acute Effects of Endurance Exercise on Breast Milk Composition in Women With Overweight/Obesity
The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on…
- Trial name
- YT (NCT05745922)
- Testing
- Moderate intensity exercise, High intensity exercise
- Where
- Norway
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Pre-diabetes
Effects of a Dietary Supplement Containing L-Arabinose and Trivalent Patented Food-source of Chromium on Blood Glucose and Insulin
This study was designed to examine changes in capillary blood glucose and venous insulin levels after a 70 gram oral sucrose challenge with and without simultaneous consumption of a dietary supplement containing L-Arabinose and a…
- Trial name
- L-Arabinose (NCT01107431)
- Testing
- L-Arabinose and Chromium, Sucrose without dietary Supplement
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Velcade and Lenalidomide in Patients With Relapsed AML and MDS After Allogeneic Stem Cell Transplantation
This research study is evaluating drugs called bortezomib and lenalidomide as a possible treatment for myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
- Trial name
- NCT02312102
- Testing
- Lenalidomide, Velcade
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Meningitis, Bacterial Infections
Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis
Prospective, multicenter, observational clinical registry of pediatric patients with acute infectious meningitis across approximately 20 public and private hospitals in Brazil.
- Conditions
- Meningitis, Bacterial Infections, Viral Meningitis, Fungal Meningitis
- Trial name
- ATLAS-II (NCT07062445)
- Where
- Brazil
- Volunteers
- 600 people
- Sponsor
- Hospital Israelita Albert Einstein
Stress
Using Affectionate Communication as a Response to Acute Stress
This study will examine the effects of tending to significant social relationships on managing and reducing stress.
- Trial name
- NCT00468572
- Testing
- Affectionate Writing, Meaningless Writing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Acute Myocardial Infarction, Acute Coronary Syndrome
Safe Emergency Department DIscharGE Rate (SEIGE)
The Siemens POC High Sensitivity Troponin-I Test System is an in vitro diagnostic test for the quantitative measurement of cardiac troponin I (cTn-I) in fresh human capillary (fingerstick) whole blood, and lithium-heparinized…
- Trial name
- SEIGE (NCT04772157)
- Testing
- Cardiac Troponin Testing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Hennepin Healthcare Research Institute
Safety and Efficacy
NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia
This trial will explore the maximum tolerated dose of cord blood NKG2D CAR-NK in the treatment of recurrent refractory acute myeloid leukemia in a dose-escalation manner, and observe its clinical safety and efficacy.
- Trial name
- NCT05247957
- Testing
- CAR-NK cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Hangzhou Cheetah Cell Therapeutics Co., Ltd
Thrombosis, Venous
The Treatment of Acute Deep Vein Thrombosis (DVT) of GSK576428 (Fondaparinux Sodium) in Japanese Patients
The primary objective of this study is to evaluate the efficacy (as measured by the rate of recurrent symptomatic Venous Thromboembolism [VTE] (i.e., Pulmonary thromboembolism [PE] and Deep Vein Thrombosis [DVT])) and safety of…
- Trial name
- NCT00911157
- Testing
- Fondaparinux sodium, unfractionated heparin (UFH)
- Where
- 24 sites in Japan
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
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