Clinical trials: Acute Hypercapnic Respiratory Failure
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Acute Mechanical Ventilatory Failure
Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation
Although High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its…
- Trial name
- RescueHFO (NCT02752438)
- Testing
- HFOV
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara University
Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia
Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)
Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations.
- Conditions
- Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia, Postoperative Respiratory Complication
- Trial name
- NCT06988111
- Testing
- BIPAP, Vapotherm
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure.
high flow nasal cannula (HFNC) oxygen therapy utilizes an air oxygen blend allowing from 21 % to 1 00% FiO2 delivery and generates up to 60 L/min flow rates The gas is heated and humidified through an active heated humidifier and…
- Trial name
- Highflow (NCT05499039)
- Testing
- High flow nasal cannula (HFNC), Non-Invasive Mechanical Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Hypercapnic Respiratory Failure, COPD
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
Hypothesis Treatment with HFNC and OptiflowTM+Duet can significantly reduce PaCO2 and normalize pH in patients with COPD exacerbation and acute hypercapnic failure, compared to HFNC with OptiflowTM.
- Trial name
- DUACT (NCT06257667)
- Testing
- Respiratory Support
- Volunteers
- 138 people
- Sponsor
- Aalborg University Hospital
Acute Mechanical Ventilatory Failure, Psychosis Associated With Intensive Care
Efficacy of Closed-loop Ventilation to Reduced Sleep Disorders
Sleep's deficiencies are very common in intensive care. Mechanical ventilation is a known factor in this deterioration.The investigators hypothesize that close-loop ventilation mode (Intellivent-ASV) is able to minimize sleep…
- Trial name
- SleepICU (NCT02095496)
- Testing
- Intellivent-ASV, Conventional ventilation
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure
The goal of this randomized crossover physiological study is to evaluate the physiologic effects of asymmetrical nasal cannula and conventional nasal cannula in patients with acute respiratory failure.
- Trial name
- NCT06204276
- Testing
- Experimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Siriraj Hospital
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation.
- Trial name
- NCT04640948
- Testing
- High flow nasal therapy, Low flow oxygen
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Belfast Health and Social Care Trust
Lung Diseases, Obstructive
ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia
Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory…
- Trial name
- NCT04842344
- Testing
- ECCO2R
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Li Xuyan
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD
Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnic Respiratory Failure, COPD
- Trial name
- NIV-ICU (NCT06888180)
- Testing
- Non interventional study
- Volunteers
- 976 people
- Sponsor
- University Hospital, Caen
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
- Trial name
- NCT03642002
- Testing
- Toning, Ocean drum & SOK melody, SOK
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypercapnic Respiratory Failure
Use of EtCO2 as a PaCO2 Predictor Under Non Invasive Ventilation (NIV) in Cases of Acute Hypercapnic Respiratory Failure
In patients treated by Non invasive ventilation (NIV) due to acute hypercapnic respiratory failure, the interest of using the End-tidal Co2 measurement device "Capnostream" to evaluate PaCo2 and PaCo2 variations over time will be…
- Trial name
- NCT01489150
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Lausanne Hospitals
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Background: In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease, Chronic Hypercapnic Respiratory Failure
- Trial name
- NCT01513655
- Testing
- LTNIV
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto