Clinical trials: Acute Hypoxemic Respiratory Failure
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Acute Hypoxemic Respiratory Failure
IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress.
- Trial name
- IntHyx (NCT07189078)
- Testing
- Restrictive intubation strategy, Liberal intubation strategy
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Acute Respiratory Failure With Hypercapnia
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasive ventilation.
- Trial name
- NCT03229460
- Testing
- standard low flow therapy, high flow nasal oxygen therapy, association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High
Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure
Mechanical ventilation can cause damage by overstretching the lungs, especially when the lungs are collapsed or edematous. Raising ventilator pressures can reduce lung collapse and this can prevent overstretching from mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High, Hypoxemic Respiratory Failure
- Trial name
- ALIVE (NCT03589482)
- Testing
- Electrical Impedance Tomography, ExPRESS-derived PEEP level
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Non-invasive Ventilation Versus High Flow Oxygen
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute…
- Trial name
- HFO (NCT03758508)
- Testing
- High Flow Oxygen nasal cannula, Noninvasive ventilation
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Niguarda Hospital
Pneumonia
HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen (HFNO) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (AHRF).
- Trial name
- NCT05809089
- Testing
- High flow nasal cannula (HFNC), Noninvasive ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Acute Respiratory Failure
Brain-lung Interaction During Acute Respiratory Failure
Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia.
- Trial name
- BrainFlow (NCT07279831)
- Testing
- EEG/NIRS/EMG
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypoxemic Respiratory Failure
HFNC and Prone Positioning in Awake Patients With Severe COVID-19
The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.
- Trial name
- NCT04982341
- Testing
- prone position
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
Extubation Failure
Post-extubation High-flow Nasal Oxygen for Preventing Extubation Failure
Patients intubated due to acute respiratory failure have a high risk of infectious complications, airway injuries and multiple organic failure, so performing a successful extubation from mechanical ventilation is key.
- Trial name
- NCT03361683
- Testing
- High-flow nasal oxygen, Venturi mask
- Where
- Mexico
- Volunteers
- 127 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Acute Hypoxemic Respiratory Failure
High-Frequency Oscillatory Ventilation Associated With Inhaled Nitric Oxide in Children
Background/Objectives: Acute hypoxemic respiratory failure (AHRF) is a frequent cause of pediatric ICU admission. Early treatment with inhaled nitric oxide (iNO) plus conventional mechanical ventilation (CMV) improves…
- Trial name
- NCT00924846
- Testing
- High frequency oscillatory ventilation
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Acute Respiratory Insufficiency
Prevalence and Outcome of Acute Hypoxemic Respiratory Failure
This study is an extension of the Spanish Initiative for Epidemiology, Stratification and Therapies of Acute respiratory failure (SIESTA) Network.
- Trial name
- PANDORA (NCT03145974)
- Testing
- mechanical ventilation
- Where
- 24 sites in Spain
- Volunteers
- 1,400 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
SARS Pneumonia
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical…
- Trial name
- COVID-VENT (NCT04445961)
- Testing
- Respiratory mechanics measurement, Gas exchange measurement
- Where
- 3 sites in Russia
- Volunteers
- 117 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COVID-19, Acute Hypoxemic Respiratory Failure
Early Versus Delayed Intubation of Patients With COVID-19
Although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (COVID-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains…
- Trial name
- EUDOCO (NCT04632043)
- Testing
- Endotracheal intubation
- Where
- Greece
- Volunteers
- 2 people
- Sponsor
- Evangelismos Hospital
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Community Acquired Pneumonia., Acute Hypoxemic Respiratory Failure
Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe Comunity Pneumonia
The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal…
- Trial name
- NIMV AND SCAP (NCT00523497)
- Testing
- Non invasive mechanical ventilation
- Where
- Argentina
- Sponsor
- Hospital Privado del Sur
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen