Clinical trials: Acute Hypoxic Respiratory Failure
Critical Care, Acute Hypoxic Respiratory Failure
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
- Trial name
- IT-PSV (NCT06526598)
- Testing
- PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Capital Medical University
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Hypoxic Respiratory Failure
Lung Ultrasound, PEEP and Overdistension (LUPO)
The investigators suppose that lung sliding could be reduced in the same lung region moving from less ventilated to overinflated condition.
- Trial name
- LUPO (NCT04648657)
- Testing
- Lung Ultrasound, Electric impedance tomography
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Padova
Survival, Prosthesis, Oxygen Deficiency
Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure
The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.
- Trial name
- NCT05866289
- Testing
- Prone position
- Where
- Morocco
- Volunteers
- 1,069 people, healthy volunteers welcome
- Sponsor
- Mohammed VI University Hospital
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
COVID-19 Pneumonia, Non-invasive Ventilation
The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia
High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05706467
- Testing
- Non-invasive high-frequency oscillatory ventilation, Non-invasive continuous positive airway pressure ventilation
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease