Clinical trials: Acute Illness
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-MED (NCT02444988)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 5,381 people
- Sponsor
- Vanderbilt University
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the…
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 AI (NCT06374225)
- Testing
- Automated Titration (O2matic)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
COVID-19
EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19
The purpose of this study is to determine whether PF-07321332/ritonavir is safe and effective for the treatment of adults who are ill with COVID-19 and do not need to be in the hospital, but are at an increased risk of developing…
- Trial name
- NCT04960202
- Testing
- PF-07321332, Ritonavir
- Where
- 201 sites in United States, Argentina and 18 more
- Volunteers
- 2,091 people
- Sponsor
- Pfizer
Healthy
Acute Respiratory Illness Surveillance (AcRIS) With Mobile Application in a Low-Interventional Decentralized Study.
The purpose of the AcRIS study is to obtain data to characterize the relationship between symptoms and voice features for (reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome…
- Trial name
- NCT04748445
- Testing
- SARS-CoV-2/Influenza/RSV RT-PCR
- Where
- United States
- Volunteers
- 9,151 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Acute Respiratory Failure
Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
The specific aim of the proposed study is to conduct a pilot study involving 160 critically-ill lean and obese patients enrolled at 11 sites in Canada, the United States of America, Belgium and France in order to: Specific Aims…
- Trial name
- TOP-UP (NCT01206166)
- Testing
- Olimel (5.7%E / N9E)
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 125 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Anti-Psychotic, Management of Manifestations of Psychotic Disorders
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Cycle Pharmaceuticals Ltd. (Cycle) is developing an oral tablet formulation of Chlorpromazine Hydrochloride and intends to conduct bioequivalence trials to demonstrate its similarity to the RLD.
- Conditions
- Anti-Psychotic, Management of Manifestations of Psychotic Disorders, Treatment of Schizophrenia, Control Nausea and Vomiting
- Trial name
- NCT02943213
- Testing
- Chlorpromazine Hydrochloride
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
Acute Mountain Sickness
Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
The study is examining if an over-the-counter device (Theravent) worn while sleeping can reduce acute mountain sickness upon awakening in a high altitude trekking population.
- Trial name
- SLEEP-AID (NCT01842906)
- Testing
- Theravent, Control
- Where
- Nepal
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Subjects
Efficacy of an Extract of Concentrated Korean Red Ginseng for Preventing Upper Respiratory Tract Infections
Upper respiratory tract infections are a major source of morbidity throughout the world. Extracts of Korean red ginseng have been found to have the potential to modulate both natural and acquired immune responses.
- Trial name
- NCT01478009
- Testing
- Korean red ginseng
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Influenza
Study of Nitazoxanide in Adults With Acute Uncomplicated Influenza
This is a randomized clinical trial designed to evaluate oral nitazoxanide compared to a placebo in the treatment of acute uncomplicated influenza in adults.
- Trial name
- NCT01056380
- Testing
- Nitazoxanide
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Romark Laboratories L.C.
Prophylaxis of Acute Mountain Sickness
Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
This is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of Acetazolamide for the prevention of High Altitude Illness.
- Trial name
- NCT01993667
- Testing
- Low Dose Acetazolamide, Normal Dose Acetazolamide
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
Venous Thromboembolism
Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients
This study will evaluate if extended therapy with oral rivaroxaban can prevent blood clots in the leg and lung that can occur with patients hospitalized for acute medical illness, and compare these results with those of the…
- Trial name
- MAGELLAN (NCT00571649)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Enoxaparin
- Where
- 676 sites in United States, Argentina and 51 more
- Volunteers
- 8,101 people
- Sponsor
- Bayer
Acute Respiratory Distress Syndrome, Critical Illness
A Study Promoting Critical Illness Recovery in the Elderly
This proposal will test the hypothesis that EARLY application of a novel early rehabilitation therapy in critically ill patients will improve functional outcomes, and change the functional trajectory of this population.
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Critical Care
- Trial name
- ASPIRE (NCT02963558)
- Testing
- cycle ergometry
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Depression
Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit
This study will determine the effectiveness of antidepressant medication in preventing depression and improving recovery in people who have been supported by mechanical ventilators in an intensive care unit (ICU).
- Trial name
- NCT00872027
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Acute Myocardial Infarction, Euthyroid Sick Syndrome
Effects of N-acetylcysteine on Low T3 Syndrome
The propose of this study is to determine whether N-acetylcysteine is effective in reversing the changes in thyroid hormones seen in critical illness, known as the low T3 syndrome.
- Conditions
- Acute Myocardial Infarction, Euthyroid Sick Syndrome, Ischemic Heart Disease
- Trial name
- NCT01501110
- Testing
- N-acetylcysteine
- Where
- 2 sites in Brazil
- Volunteers
- 83 people
- Sponsor
- Federal University of Rio Grande do Sul
Respiratory Syncytial Virus
A Study to Evaluate the Efficacy of MEDI7510 in Older Adults
This study will be the first assessment of the efficacy of MEDI7510 for the prevention of respiratory syncytial virus (RSV) disease. It will also provide estimates of vaccine efficacy and of endpoint incidence in the placebo arm.
- Trial name
- NCT02508194
- Testing
- MEDI7510, IIV
- Where
- 61 sites in United States, Canada and 5 more
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Influenza, Acute Respiratory Infection
FluSAFE: Flu SMS Alerts to Freeze Exposure
Influenza infection results in an estimated 31 million outpatient visits, 55,000 to 974,200 hospitalizations, and 3,000 to 49,000 deaths.
- Conditions
- Influenza, Acute Respiratory Infection, Influenza-like Illness
- Trial name
- NCT03274310
- Testing
- Educational text messages
- Where
- United States
- Volunteers
- 1,918 people, healthy volunteers welcome
- Sponsor
- Columbia University