Clinical trials: Acute Infectious Diseases
Long COVID-19 Syndrome, Post COVID Syndrome Long Covid
Inspiratory Muscle Pressure and Diaphragmatic Strength in Women With Long COVID-19: A Pressure Biofeedback-Guided Training Study
COVID-19 is an infectious disease that can cause long-term health problems even after the acute infection has resolved. Many people who have recovered from COVID-19 continue to experience breathing difficulties, fatigue, and…
- Conditions
- Long COVID-19 Syndrome, Post COVID Syndrome Long Covid, Post COVID-19 Syndrome
- Trial name
- NCT07397130
- Testing
- Pressure Biofeedback Unit
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- RSUP Persahabatan
Inflammation
Evaluation and Long-Term Follow-up of Patients With Inflammatory Disorders
This study will investigate inflammatory diseases and disorders. Inflammation is the body s immune response to many things, including infections and other acute or chronic irritants.
- Trial name
- NCT00001351
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Long COVID
Qigong for Post Acute Sequelae of COVID-19 Infection
The purpose of this study is to conduct a pilot feasibility study of a combination of external and internal qigong on health-related quality of life in individuals with prolonged symptoms following COVID-19 infection.
- Trial name
- NCT05675995
- Testing
- Qigong
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Davis
Hepatitis C
HCV Treatment Initiation During Acute Psychiatric Admission
Hepatitis C virus (HCV) disproportionally affects certain populations, including those facing substance use and mental health challenges.
- Trial name
- NCT04625322
- Testing
- HCV care provided by hospitalist during acute psychiatric admission
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University Health Network, Toronto
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Respiratory Infection (for Example, Pneumonia, Bronchitis), Antibiotic
Intermountain Stewardship in Community Outpatient Settings-Resources & Engagement-Pediatrics
The goal of this implementation project is to detail the process of implementing the best practice of antibiotic stewardship in the pediatric population across the Intermountain Health medical system.
- Conditions
- Respiratory Infection (for Example, Pneumonia, Bronchitis), Antibiotic, Antibiotic Duration, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- SCORE-Peds (NCT07334795)
- Testing
- Implementation strategies including training & education, EMR tools, audit & feedback reports, and facilitation
- Where
- United States
- Volunteers
- 259,000 people
- Sponsor
- Intermountain Health Care, Inc.
Febrile Illness Acute, Meningitis, Bacterial
Febrile Infants Swedish Study
Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States.
- Conditions
- Febrile Illness Acute, Meningitis, Bacterial, Urinary Tract Infection (Diagnosis), Invasive Bacterial Infection
- Trial name
- FISS (NCT07134751)
- Where
- 11 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
COVID-19
Long-term Impact on Cardiopulmonary Function and Quality of Life in Patients Recovered From COVID-19.
FUNCTION is an observational cohort study conducted by researchers from the Instituto de Medicina Tropical Alexander von Humboldt at Universidad Peruana Cayetano Heredia and Cayetano Heredia Hospital.
- Trial name
- FUNCTION (NCT05386485)
- Testing
- None intervation
- Where
- Peru
- Volunteers
- 162 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Covid19, Coronavirus Infection
Randomized Phase IIA Clinical Trial to Evaluate the Efficacy of Ivermectin to Obtain Negative PCR Results in Patients With Early Phase COVID-19
SAINT-PERU is a triple-blinded, randomized placebo-controlled trial with two parallel arms to evaluate the efficacy of ivermectin in negativizing nasopharyngeal PCR in patients with SARS-CoV-2 infection.
- Conditions
- Covid19, Coronavirus Infection, SARS-CoV Infection
- Trial name
- SAINT-PERU (NCT04635943)
- Testing
- Ivermectin
- Where
- Peru
- Volunteers
- 186 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Corona Virus Infection, Pediatric Cancer
Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coronavirus 2019 (COVID-19) In Children
Patient are being asked to provide respiratory and blood samples for a clinical research study because the patients have a virus called the novel coronavirus, or SARS-CoV-2, that causes the disease known as Covid-19.
- Conditions
- Corona Virus Infection, Pediatric Cancer, Adult Children, Cancer
- Trial name
- NCT04371315
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Jude Children's Research Hospital
Acute Pancreatitis, Necrosis; Pancreas, Acute (Infectious)
Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis
In acute pancreatitis, approximately 20% of the cases result in severe necrotizing pancreatitis which is associated with significant morbidity and mortality.
- Trial name
- RESOlVE (NCT04814693)
- Testing
- EndoRotor® System (Interscope, Inc., Northbridge, MA USA),, Conventional endoscopic devices (according to standards of care)
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Hepatitis C Virus (HCV)
Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB)
HCV infection is a global health problem. HCV mainly affects liver cells and causes the liver to become inflamed and damaged. This study will evaluate how safe and effective glecaprevir/pibrentasvir (GLE/PIB) is in adult and…
- Trial name
- NCT04903626
- Testing
- Glecaprevir/Pibrentasvir (GLE/PIB)
- Where
- 70 sites in United States, Australia and 6 more
- Volunteers
- 286 people
- Sponsor
- AbbVie
Binge Drinking, Unsafe Sex
Individual and Contextual Factors That Influence Sexual Decisions
For decades, men who have sex with men (MSM) have carried the heaviest burden associated with the HIV epidemic in the United States.
- Conditions
- Binge Drinking, Unsafe Sex, HIV/AIDS, Sexually Transmitted Diseases
- Trial name
- NCT03224416
- Testing
- Alcohol Administration, No Alcohol Administration
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brown University
Respiratory Syncytial Virus (RSV)
Safety and Preliminary Immunogenicity of Recombinant RSV Vaccine （CHO Cell） in Adults Aged 18 Years and Older
This phase 1 study in China will evaluate the Safety and Preliminary Immunogenicity of Recombinant RSV Vaccine (CHO Cell) in Adults Aged 18 Years and Older
- Trial name
- NCT07807449
- Testing
- Recombinant RSV Vaccine (CHO Cell), Adjuvant Suspension, Recombinant RSV Vaccine (CHO Cell) with Adjuvant Suspension
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Yikang Biotech (Suzhou) Co., Ltd.
Post-Acute COVID-19, Post-Acute COVID-19 Infection
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection.
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Infection, Post-Acute COVID-19 Syndrome, Pulmonary Fibrosis
- Trial name
- FAPI CLIMATE (NCT05981885)
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Long Covid19, Neuropsychiatric Symptoms
Electro-acupuncture for Long Covid Neuropsychiatric Symptoms
In this study, a 16-week randomized, sham-controlled, double-blinded clinical trial will be conducted to to investigate the efficacy and safety of electro-acupuncture compared to sham acupuncture for treatment of long covid…
- Conditions
- Long Covid19, Neuropsychiatric Symptoms, Electro-acupuncture
- Trial name
- NCT05890508
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Hong Kong Baptist University
SARS-CoV Infection, COVID-19
Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19
Adults who do not have major health, kidney, gastrointestinal disease will be randomized to receive oral mitoquinone/mitoquinol mesylate (Mito-MES) versus placebo to prevent the development and progression of COVID-19 after…
- Trial name
- NCT05886816
- Testing
- Mitoquinone/mitoquinol mesylate
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
COVID-19, Coronavirus Infection
Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"
The COVID-19 pandemic has been characterized by high morbidity and mortality, especially in certain subgroups of patients. To date, no treatment has been shown to be effective in controlling this disease in hospitalized patients…
- Conditions
- COVID-19, Coronavirus Infection, Virus Disease, Acute Respiratory Infection
- Trial name
- NCT04403100
- Testing
- Hydroxychloroquine Sulfate Tablets, Lopinavir/ Ritonavir Oral Tablet, Hydroxychloroquine Sulfate Tablets plus Lopinavir/ Ritonavir Oral Tablets
- Where
- 4 sites in Brazil
- Volunteers
- 1,968 people
- Sponsor
- Cardresearch
Hyponatremia, SIADH
Tolvaptan for Patients With Acute Neurological Injuries
Hyponatremia occurs frequently in patients with acute brain injury in the days to weeks following injury, and may contribute to adverse outcome.
- Trial name
- NCT02545114
- Testing
- Tolvaptan
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Polderman, Kees, H., MD, PhD
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