Clinical trials: Acute Infectious Diseases
Corona Virus Infection, Pneumonia, Ventilator-Associated
Mucolytics in Patients on Invasive Mechanical Ventilation Due to Severe Acute Respiratory Syndrome Coronavirus 2
It is planned to include patients over 18 years of age of both sexes, admitted to the Intensive Care Unit of Clinical Hospital Centre Split for respiratory insufficiency caused by severe acute respiratory syndrome coronavirus 2…
- Trial name
- NCT04755972
- Testing
- Inhalation of N-acetylcysteine, Inhalation of 5% sodium chloride, Inhalation of 8,4% sodium bicarbonate
- Where
- Croatia
- Volunteers
- 175 people
- Sponsor
- Clinical Hospital Center, Split
Liver Failure, Acute on Chronic, Liver Injury
A Retrospective Multicenter Study of HBV-related Pre-acute-on-chronic Liver Failure in China
The definition and diagnostic criteria of Acute-on-chronic liver failure (ACLF) has been well established by EASL CANONIC study. However, patients with high risk to develop ACLF has not been determined, yet.
- Trial name
- NCT03281265
- Testing
- standard treatment
- Volunteers
- 1,178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Lymphoblastic Leukemia
Observational Study on Invasive Fungal Infection Incidence in Ph-neg Acute Lymphoblastic Leukemia Patients
Primary objective To document the occurrence of fungal infections during the early stages of chemotherapy (from onset to TP2, i.e., week 16) in adult Ph-neg ALL patients Secondary objectives To document the occurrence of IFI in…
- Trial name
- ALL-IFI (NCT06392581)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Influenza, Human, Acute Respiratory Infection
Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infections
The study is planned to evaluate the therapeutic efficacy and safety of Ingavirin®, capsules, 60 mg, in the treatment of influenza or other acute respiratory infections in children from 13 to 17 years compared with placebo.
- Conditions
- Influenza, Human, Acute Respiratory Infection, Common Cold
- Trial name
- NCT06315400
- Testing
- Ingavirin®
- Where
- 3 sites in Russia
- Volunteers
- 80 people
- Sponsor
- Valenta Pharm JSC
COVID-19, Coronavirus Disease 2019
A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza.
The main purpose of this study is to understand: the symptoms of COVID-19 or influenza health-related outcomes of people with COVID-19 or influenza the effects of vaccines in people with COVID-19 or influenza.
- Conditions
- COVID-19, Coronavirus Disease 2019, Influenza
- Trial name
- NCT06163677
- Testing
- COVID-19 Vaccine
- Sponsor
- Pfizer
Respiratory Syncytial Virus (RSV), Respiratory Viral Infection
Effect of Respiratory Virus Infection on EmeRgencY Admission Study (EVERY Study)
Study design is multicenter prospective registry study. Participants are consecutive (non-selected, a sequential registration) patients admitted from emergency rooms of participating hospitals who meet the eligibility criteria.
- Conditions
- Respiratory Syncytial Virus (RSV), Respiratory Viral Infection, Acute Disease
- Trial name
- EVERY (NCT05913700)
- Where
- 3 sites in Japan
- Volunteers
- 3,067 people
- Sponsor
- Institute for Clinical Effectiveness, Japan
Post-Acute COVID-19 Syndrome
Incidence, Associated Factors, and Burden of Post COVID-19 Condition in Brazil
This is a national retrospective cohort study with internet-based recruitment which intends to enroll 1,694 adult patients with COVID-19 diagnosis during the SARS-CoV-2 omicron wave in Brazil.
- Trial name
- NCT05822193
- Testing
- Multiple exposures
- Where
- Brazil
- Volunteers
- 1,694 people, healthy volunteers welcome
- Sponsor
- Inova Medical
Peri-Implantitis, Sinusitis
"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".
Scientific evidence regarding the influence of peri-implantitis on Schneider's membrane thickening is scarce and limited. Similarly, to date, there is no literature documenting the resolution of implant-associated maxillary…
- Conditions
- Peri-Implantitis, Sinusitis, Sinusitis, Acute, Sinusitis, Chronic
- Trial name
- NCT05924711
- Testing
- Retrospective analysis of demographic and radiographic data previously obtained from the patient.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Universitat Internacional de Catalunya
Long Covid19
Long-term Effects of SARS-CoV-2 on the Central Nervous System and One-year Follow-up of "Long COVID-19" Patients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh coronavirus known to infect humans, and causing coronavirus disease 2019 (COVID-19). .
- Trial name
- NCT05492292
- Testing
- Perfusion brain scintigraphy imaging
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Brugmann University Hospital
Acute Upper Respiratory Infection, Signs and Symptoms
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)
This is a nonblinded randomized controlled trial which is a survey-based comparison between supportive treatments for symptom relief from pediatric upper respiratory infection (URI).
- Trial name
- NCT01814293
- Testing
- Handheld humidifier
- Where
- United States
- Sponsor
- University of California, San Francisco
Long COVID, Long Coronavirus Disease 2019 (Covid19)
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Coronavirus Disease 2019 (Covid19), Long Covid-19
- Trial name
- NCT06305793
- Testing
- IVIG (intravenous immunoglobulin), Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Kanecia Obie Zimmerman
Acute Appendicitis, Superficial SSI
Laparoscopic vs Open Appendectomy
his randomized controlled trial was conducted to compare the frequency of superficial surgical site infections (SSIs) following laparoscopic appendectomy and open appendectomy in patients undergoing surgical treatment for acute…
- Trial name
- NCT07841444
- Testing
- Laparoscopic appendectomy, Open Appendectomy
- Where
- Pakistan
- Volunteers
- 276 people
- Sponsor
- Quaid-e-Azam Medical College
COVID-19
Pulmonary Rehabilitation Post-COVID-19
The main objective of this pilot study was to evaluate the feasibility, safety, and satisfaction of a remote interdisciplinary PR program delivered using two exercise approaches (video conference and self-directed) on the…
- Trial name
- NCT05003271
- Testing
- Exercise program (virtual/remote)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Infectious Mononucleosis, Splenomegaly
The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute…
- Trial name
- NCT02463669
- Testing
- Point-of-care ultrasound
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Influenza and Other Novel Respiratory Viruses
Respiratory Virus Outpatient Study (FLU 002 Plus)
Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to describe participants seeking medical care in geographically diverse locations with 2009 H1N1…
- Trial name
- NCT01056354
- Where
- 68 sites in United States, Argentina and 13 more
- Volunteers
- 11,719 people
- Sponsor
- University of Minnesota
Post COVID-19 Syndrome, Functional Inspiratory Muscle Training
Effectiveness of Functional Respiratory Muscle Training in Post-COVID-19 Syndrome
This study aims to investigate the effects of core stabilization exercises and functional inspiratory muscle training (IMT) on various physiological and psychological parameters in individuals with post-COVID-19 syndrome.
- Conditions
- Post COVID-19 Syndrome, Functional Inspiratory Muscle Training, Core Stabilization
- Trial name
- NCT07051954
- Testing
- Core Stabilization, Functional Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
COVID-19, Long COVID
A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study
This study will evaluate the long-term sequelae of COVID-19 in patients diagnosed with COVID-19 who previously enrolled in a RO7496998 (AT-527) study (i.e.
- Trial name
- MEADOWSPRING (NCT05059080)
- Where
- 35 sites in Argentina, Belgium and 8 more
- Volunteers
- 72 people
- Sponsor
- Hoffmann-La Roche
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Follow-up of Covid-19 Long Term Sequelae
The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05097677
- Testing
- Not applicable (observational study)
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 7,599 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
SARS-CoV Infection
Chemoprevention Clinical Trial of COVID-19: Hydroxychloroquine Post Exposure Prophylaxis
Protocol summary Title A Prospective, randomized, adaptive phase II/III clinical trial, controlled, open-label, chemoprevention, 3-arms, parallel, multi-centred, to A Prospective, randomized, clinical trial, controlled…
- Trial name
- APCC-19 (NCT04597775)
- Testing
- hydroxychloroquine
- Volunteers
- 93 people
- Sponsor
- Regional Center for Disease Control and Prevention, Jordan
SARS-CoV
Validation of a Rapid, Non-invasive Point-of-care IVD Test for Diagnosis of SARS-COV-2 (COVID-19) Infection
A prospective non-interventional study to evaluate the performance of EASYCOV IVD as point-of-care (POC) test by comparing SARS-CoV-2 positive patients with SARS-CoV-2 negative controls on paired specimens (nasopharyngeal swabs…
- Trial name
- EasyCov (NCT04583319)
- Testing
- EasyCov POC
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Firalis SA
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