Clinical trials: Acute Infectious Diseases
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Long COVID-19 Syndrome
Digital Physiotherapy Practice in Long Covid-19 Patients
The COVID-19 can cause important sequels in the respiratory system by bilateral pneumonia and frequently presents loss of strength, dyspnea, polyneuropathies and multi-organic affectation.
- Trial name
- TRCovidA (NCT04742946)
- Testing
- Digital Physiotherapy Practice (Telerehabilitation)
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
SARS-CoV Infection
SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)
The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients. Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives…
- Trial name
- NCT04750356
- Where
- 3 sites in United Kingdom
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Acute HIV Infection
Early cART and cART in Combination With Autologous HIV-1 Specific Cytotoxic T Lymphocyte (CTL) Infusion in The Treatment of Acute HIV-1 Infected Adults
The purpose of this study is to assess the ability of the early initiation of cART or cART in combination with autologous HIV-1 specific cytotoxic T lymphocyte (CTL) infusion to achieve a post-treatment control among…
- Trial name
- NCT02231281
- Testing
- cART(TDF/AZT+3TC+LPV/r), CTL infusion
- Where
- 7 sites in China
- Volunteers
- 65 people
- Sponsor
- Yongtao Sun, MD, PhD
COVID-19, Acute Respiratory Infection
Prophylaxis and Treatment of COVID-19
An observation study evaluating physiologic responses and host biomarker expression patterns in early SARS-CoV-2 and acute respiratory infections (ARI) and among their close contacts.
- Trial name
- PROTECT-APT (NCT04844541)
- Where
- 3 sites in United States, Thailand
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Acute Pain in Herpes Zoster
NPC-06 to Pain Associated With Acute Herpes Zoster
To confirm the pain relief effect and the safety of NPC-06 (fosphenytoin sodium hydrate) in patients with pain associated with acute herpes zoster in a placebo-controlled, double-blind, parallel-group, comparative manner.
- Trial name
- NCT05480553
- Testing
- NPC-06
- Where
- 20 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Nobelpharma
Long COVID
Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID
This will be a six-week, randomized, parallel, two group, open-label design. Patients will be treated with Paragon Novel Metabolic Regulator (PNMR) + standard of care (SOC) or SOC alone for 6 weeks for the treatment of Long…
- Trial name
- NCT07627815
- Testing
- Paragon Novel Metabolic Regulator (PNMR), Dietary and Lifestyle Recommendations
- Where
- 4 sites in Canada
- Volunteers
- 82 people
- Sponsor
- ParagonClinicals Inc.
SARS CoV 2 Infection, Alveolar; Injury
The Potential Role of sRAGE, KL-6, and SP-D as Prognostic Factors in Children With COVID-19
COVID-19 causes a wide spectrum of clinical illness, from upper respiratory symptoms to severe respiratory failure and death. Several plasma biomarkers -such as IL-6, C-reactive protein (CRP), D-dimer, the…
- Conditions
- SARS CoV 2 Infection, Alveolar; Injury, Children, Pneumonia, Viral
- Trial name
- NCT05619640
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Meningitis, Cryptococcal, HIV Infections
Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
To evaluate the safety and effectiveness of fluconazole as treatment for acute cryptococcal meningitis in AIDS patients. Both newly diagnosed and relapsed patients are eligible.
- Trial name
- NCT00002076
- Testing
- Fluconazole
- Where
- 3 sites in United States
- Sponsor
- Pfizer
COVID, Corona Virus Infection
hCT-MSCs for COVID19 ARDS
This is a 50 patient, Phase 1/2a multi-center pilot study to test the safety and to describe the preliminary efficacy of intravenous administration of allogenic human cord tissue mesenchymal stromal cells (hCT-MSC) as an…
- Conditions
- COVID, Corona Virus Infection, COVID19
- Trial name
- NCT04399889
- Testing
- Human cord tissue mesenchymal stromal cells (hCT-MSC) manufactured by Duke University.
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Joanne Kurtzberg, MD
COVID - 19, Diabetes Mellitus
DIFFERENT SARS-COV-2 VARIANTS' EFFECT ON THE COURSE OF COVID-19 IN ESTONIAN CHILDREN
The study focuses on Estonian children under 18 who had COVID-19 from 27.02.2020 to 01.03.2023. The main aim is to find out the risk factors for severe COVID-19 in children.
- Conditions
- COVID - 19, Diabetes Mellitus, Post-COVID Conditions, MIS-C Associated With COVID-19
- Trial name
- NCT06784713
- Where
- Estonia
- Volunteers
- 127,277 people
- Sponsor
- University of Tartu
SARS-CoV Infection
SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel Following mRNA COVID-19 Vaccination
A novel zoonotic coronavirus was discovered in Wuhan (Hubei Province, China) mid-December 2019 and was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04880174
- Testing
- serological testing
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Long COVID
Exercise for Health in Patients With Post-acute Sequelae of COVID-19
Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ant…
- Trial name
- EJerSA-COVID (NCT05848518)
- Testing
- Rehabilitation program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
Long-COVID, PASC
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID
This study is investigating the effects of using an Osteopathic Manipulative Therapy (OMT) treatment protocol that was shown to statistically improve smell in individuals suffering from Long-COVID olfactory (smell) dysfunction in…
- Conditions
- Long-COVID, PASC, Long COVID Syndrome
- Trial name
- NCT06883513
- Testing
- Osteopathic Manipulative Therapy Long-COVID protocol, Osteopathic Manipulative Therapy NOT Long-COVID treatment protocol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Upper Respiratory Tract Infection;, Acute Tracheobronchitis
A Registry Study on Reduning（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in January 2013.
- Trial name
- NCT01824719
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Hematopoietic Stem Cell Transplantation
PTCy-ATG vs ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis
The granulocyte colony-stimulating factor (G-CSF)+antithymocyte globulin (ATG)-based protocols and posttransplantation cyclophosphamide (PTCy) protocols have been widely used for graft-versus-host disease (GVHD) prophylaxis in…
- Trial name
- NCT03689465
- Testing
- ATG, CTX, Mycophenolate Mofetil
- Where
- 7 sites in China
- Volunteers
- 260 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Osteoarthritis, Rheumatoid Arthritis
A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809
Randomized, Open-label, Oral, Single-dose, two-Sequence, four-Period, crossover study
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Back Pain, Acute Upper Respiratory Tract Infection
- Trial name
- NCT05214677
- Testing
- DW1809, DW1809-1
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
SARS-CoV-2 Infection, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-RETRO (NCT04534400)
- Testing
- thoracic CT-scan
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Brain Injury, Hydrocephalus
VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1.
- Conditions
- Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
- Trial name
- LACTIC (NCT07380477)
- Testing
- Sampling of blood and cerebrospinal fluid
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Infections in Children
Multicenter Study to Evaluate Efficacy, Tolerability, Safety of Derinat
This multicenter prospective double blinded placebo-controlled randomized study is designed to to evaluate clinical efficacy, tolerability and safety of medical product Derinat®, solution for external and local use 0.25% in acute…
- Trial name
- NCT04149431
- Testing
- Derinat
- Where
- Russia
- Volunteers
- 350 people
- Sponsor
- PharmPak, LLC
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.