Clinical trials: Acute Infectious Diseases
Covid19, Kidney Diseases
Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19
To better understand the role of inflammation in COVID-19, we established the Michigan Medicine COVID-19 Cohort (M2C2). M2C2 is a funded and ongoing cohort which has currently enrolled over 1500 adult patients (≥18 years) with…
- Conditions
- Covid19, Kidney Diseases, Inflammation, SARS-CoV Infection
- Trial name
- M2C2 (NCT04706533)
- Testing
- Biomarkers of inflammation
- Where
- United States
- Volunteers
- 3,402 people
- Sponsor
- University of Michigan
ANCA Associated Vasculitis
Subclinical Cytomegalovirus Reactivation in Acute ANCA-associated Vasculitis
This is a prospective observational study to determine the frequency and magnitude of Cytomegalovirus (CMV) reactivation in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) in the acute…
- Trial name
- REACTIVAS (NCT04916704)
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Skin and Subcutaneous Tissue Bacterial Infections
Delafloxacin Versus Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections
This study was designed to evaluate the efficacy of delafloxacin patients with acute bacterial skin and soft tissue infections (ABSSSI).
- Trial name
- NCT01811732
- Testing
- Delafloxacin, Vancomycin, Aztreonam
- Where
- 50 sites in United States, Croatia and 5 more
- Volunteers
- 660 people
- Sponsor
- Melinta Therapeutics, Inc.
Long Haul COVID-19, Post-Acute COVID-19 Syndrome
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction
The goal of this pilot study is to assess the feasibility and impact of using sodium citrate nasal spray as an adjunct to olfactory retraining in participants with long-term post-COVID-19 olfactory dysfunction.
- Conditions
- Long Haul COVID-19, Post-Acute COVID-19 Syndrome, Anosmia, Olfaction Disorders
- Trial name
- NCT06204432
- Testing
- Sodium Citrate, Normal Saline, Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx"
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Respiratory Disease, COVID-19
REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
Background: Many adults and some children with COVID-19 or acute respiratory infection become critically ill and need advanced life support in the Intensive Care Unit (ICU).
- Conditions
- Respiratory Disease, COVID-19, Viral Infection
- Trial name
- REVIVe (NCT05246098)
- Where
- 26 sites in Canada
- Volunteers
- 679 people
- Sponsor
- McMaster University
Long COVID, Long Coronavirus Disease 2019 (Covid19)
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Coronavirus Disease 2019 (Covid19), Long Covid-19
- Trial name
- NCT06305793
- Testing
- IVIG (intravenous immunoglobulin), Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Kanecia Obie Zimmerman
Cardiovascular Abnormalities, Post-COVID-19 Syndrome
Inspiratory Muscle Strength Training in Post-Covid Syndrome
Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19.
- Conditions
- Cardiovascular Abnormalities, Post-COVID-19 Syndrome, Physical Exercise
- Trial name
- NCT06091384
- Testing
- Inspiratory muscle strength training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- D'Or Institute for Research and Education
HIV Infections
Antiretroviral Therapy for Acute HIV Infection
This study will evaluate the virologic effect, safety and tolerability of Genvoya® in adults during early acute HIV infection.
- Trial name
- NCT03877536
- Testing
- Genvoya 150Mg-150Mg-200Mg-10Mg Tablet
- Where
- Uganda
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Hepatitis B, Acute-On-Chronic Liver Failure
Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure
This study is to investigate the long-term outcomes and prognostic risk factors in patients recovered from hepatitis B virus related acute on-chronic liver failure.
- Trial name
- NCT04310787
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Dysexecutive Syndrome, Post-Acute Sequelae of COVID-19
Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)
The main goal of this study is to improve dysexecutive symptoms (e.g., sustained attention, processing speed) in patients exhibiting post-acute sequelae of COVID-19 (PASC) through home-based transcranial direct current…
- Trial name
- NCT05092516
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Hypersomnia
- Trial name
- NCT06404099
- Testing
- Modafinil, Solriamfetol
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- Duke University
Mastoiditis; Acute
Corticosteroids as an Additional Treatment for Mastoiditis In Children
The aim of the study is to assess the influence of adjuvant corticosteroid treatment in acute mastoiditis in children. we expect a better outcome in children treated with both corticosteroids and antibiotics including lower rates…
- Trial name
- COSMIC (NCT04828525)
- Testing
- Dexamethasone, normal saline
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ori snapiri
Acute Bacterial Skin and Skin Structure Infections
Oral Sodium Fusidate (CEM-102) Versus Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections
Phase 3, randomized, double-blind, multi-center efficacy and safety study to evaluate an oral CEM-102 loading dose regimen compared to oral linezolid in the treatment of subjects with ABSSSI
- Trial name
- NCT02570490
- Testing
- sodium fusidate, linezolid
- Where
- 62 sites in United States, Puerto Rico
- Volunteers
- 716 people
- Sponsor
- Arrevus Inc.
Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID)
Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE)
Post-acute infectious syndrome (PAIS), including post-COVID-19 condition (PCC or Long COVID), can develop after an infection and may cause persistent symptoms such as fatigue, problems with memory and concentration ("brain fog")…
- Trial name
- PAISE-AriSE (NCT07714213)
- Testing
- Aripiprazole (low-dose, 1mg)
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Christiana Franke
SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome)
Methylprednisolone in COVID-19 Patients (Methyl19LGH)
In COVID-19 deep airway and alveolar destruction occurred due to inflammatory reaction resulting into severe pneumonia. In COVID-19, lung injury is not only due to viral damage to tissue, but it is also due to immune response…
- Trial name
- Methyl19LGH (NCT04559113)
- Testing
- Methylprednisolone Injectable Product
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Lahore General Hospital
Parvovirus B19 Infection
Parvovirus B19 Infection in Hereditary Hemolytic Anemias Patients
Although many studies investigated the prevalence and manifestations of HPV-B19 infection in patients with sickle cell anemia (SCA), thalassemia, and hereditary spherocytosis (HS) separately, there is limited information about…
- Trial name
- NCT04822090
- Testing
- Supportive treatment with or without red cell transfusion/intravenous immune globulin (IVIG)
- Where
- Egypt
- Volunteers
- 244 people
- Sponsor
- Sohag University
HIV Infections
Nine Month Course of Anti-HIV Medications for People Recently Infected With HIV
Although some doctors favor starting anti-HIV treatment as soon as possible after patients learn they are infected, it is not known if treatment for recently infected patients results in long-term benefits or harm.
- Trial name
- NCT00090779
- Testing
- Emtricitabine/ tenofovir disoproxil fumarate, Lopinavir/Ritonavir
- Where
- 27 sites in United States, Peru
- Volunteers
- 130 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Myocarditis Acute
Analysis of Cardiac Damage Post Infection With SARS-CoV-2 and Post Vaccination Against COVID-19
From May 2020 to May 2021, the investigators retrospectively evaluated clinical cardiac magnetic resonance (CMR) examinations performed in patients with suspected cardiac involvement post COVID-19.
- Trial name
- NCT05124223
- Testing
- Cardiac MRI
- Where
- Germany
- Volunteers
- 131 people
- Sponsor
- Sebastian Kelle
Abscess, Wound Infection
Single Dose vs. Two Dose Regimen of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
To compare the efficacy of treatment with a single dose of dalbavancin 1500 mg to treatment with a two dose regimen of dalbavancin (1000 mg on Day 1 followed by 500 mg on Day 8) in participants with known or suspected…
- Conditions
- Abscess, Wound Infection, Surgical Site Infection, Cellulitis
- Trial name
- NCT02127970
- Testing
- Dalbavancin
- Where
- 78 sites in United States, Bulgaria and 10 more
- Volunteers
- 698 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404073
- Testing
- Structured Pacing, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
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