Clinical trials: Acute Infectious Diseases
Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome)
EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the most frequent complications of the COVID-19 pandemic.
- Conditions
- Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Virus Diseases, Coronaviridae Infections
- Trial name
- BEVA (NCT04822818)
- Testing
- BEVA+SOC, SOC
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Acute Respiratory Failure
Influence of Vibroacoustic Therapy Modes on the Course of Coronavirus Infection
Assessment of the dynamics of changes in physical, instrumental and laboratory parameters in patients with identified coronavirus infection complicated by acute respiratory failure included in the study in accordance with the…
- Conditions
- COVID-19, Acute Respiratory Failure, Vibration; Exposure
- Trial name
- NCT05143372
- Testing
- Vibrolung
- Where
- 3 sites in Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Astana Medical University
Acute Myeloid Leukemia
Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy
This is a prospective, observational study to establish the connection between periodontitis and BSI in AML patients planning to receive intensive chemotherapy.
- Trial name
- NCT04858594
- Testing
- Planned Chemotherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis)
Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases
This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations.
- Conditions
- Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis), NMOSD, Acute Disseminated Encephalomyelitis
- Trial name
- TACS-CI-IIDDs (NCT07087873)
- Testing
- Neuroelectrical modulation group, Pseudo-neuromodulation group
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Xuanwu Hospital, Beijing
Tonsillitis Acute, Pneumonia - Bacterial
Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care Center
This study was initiated because of the limited litterature available on this topic. The objective was to compare adherence to antibiotic therapy among a pediatric population treated in two healthcare settings in France: the…
- Conditions
- Tonsillitis Acute, Pneumonia - Bacterial, Otitis Media Acute, Cystitis Acute
- Trial name
- ObsATBGignaUrg (NCT07711756)
- Volunteers
- 191 people
- Sponsor
- University Hospital, Montpellier
Long COVID
Treatment of Long COVID Symptoms Utilizing Autologous Stem Cells Following COVID-19 Infection
The project is described as a Phase 1 Clinical Safety Study intended to provide preliminary assessments of the safety, tolerability, and secondarily to be vigilant for signals of amelioration of symptoms associated with…
- Trial name
- NCT05669261
- Testing
- Adipose Tissue Harvest, ATCell
- Volunteers
- 20 people
- Sponsor
- American CryoStem Corporation
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Disease
- Trial name
- OPTICAP>30 (NCT04519086)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Long COVID, Chronic Fatigue Syndrome
Vagus Nerve Stimulation as Treatment for Long Covid
Many patients do not recover following Covid infection. The resulting illness is called Long Covid. Because there is no agreed upon treatment for this ailment, the research team has decided to do an open label pilot study using…
- Trial name
- NCT05608629
- Testing
- Transcutaneous Non-Invasive Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Long COVID Symptoms
Vagal Approaches on Long COVID-19
The purpose of this study is to explore whether two general wellness products, alone or combined, can support individuals experiencing Long COVID symptoms.
- Trial name
- NCT07190105
- Testing
- Sonocea Sonic Augmentation Technology (SAT), Truvaga Electrical Vagus Nerve Stimulator
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- Leidos Life Sciences
COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
A Study to Evaluate the Safety and Efficacy of C19-IG 20% in SARS-CoV-2 Infected Asymptomatic Ambulatory Outpatients
The purpose of the study is to compare the efficacy of anti-COVID-19 immune globulin (human) 20% (C19-IG 20%) (2 doses) versus placebo with regard to the percentage of asymptomatic participants who remain asymptomatic, i.e., who…
- Trial name
- COVID-19 (NCT04847141)
- Testing
- C19-IG 20%, 0.9% Sodium chloride
- Where
- 12 sites in Spain
- Volunteers
- 465 people
- Sponsor
- Grifols Therapeutics LLC
Long Covid19
Non-pharmacological and TCM-based Treatment for Long COVID Symptoms
Cognitive impairment is one of the commonly reported Long COVID symptoms, mainly in terms of memory, attention, and executive function.
- Trial name
- NCT06042777
- Testing
- Acupuncture and TCM-based lifestyle management
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Systemic Inflammation, Neuroinflammation
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Background: COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way.
- Conditions
- Systemic Inflammation, Neuroinflammation, Microvascular Thrombosis
- Trial name
- NCT05350774
- Testing
- IV normal saline, IV immunoglobulin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post-acute COVID-19 Syndrome
Education of Medical Staff to Post Acute Covid susTained sYmptoms
Evaluation of the effectiveness of a training and support intervention for general practitioners treating patients with persistent symptoms after a COVID-19 episode on the patients'quality of life at 3 months.
- Trial name
- EMPATY (NCT06082258)
- Testing
- Training in the management of functional disorders, Reimbursement of 3 long consultations
- Where
- 7 sites in France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
Lactoferrin in Covid-19 Hospitalized Patients
TRIAL LAC is a randomized double-blind non profit multicenter study with a nutritional product: bovine lactoferrin - Mosiac 200 mg.
- Trial name
- LAC (NCT04847791)
- Testing
- Bovine lactoferrin
- Where
- 2 sites in Italy
- Volunteers
- 194 people
- Sponsor
- Paolo Manzoni
Corona Virus Disease 19 (Covid19), Corona Virus Infection
Effect of N-acetylcysteine on Oxidative Stress in COVID-19 Patients
The purpose of the study is to assess the potential therapeutic effect of N-acetylcysteine "NAC" in COVID 19 patients.
- Conditions
- Corona Virus Disease 19 (Covid19), Corona Virus Infection, Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV2)
- Trial name
- NCT04792021
- Testing
- N-acetylcysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Covid19, Infertility, Male
Impact of the Coronavirus Disease 2019 (COVID-19) on Sperm Parameters
This study aims to better understand the effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virus that causes the coronavirus disease 2019 (COVID-19), on male fertility.
- Trial name
- NCT04937608
- Testing
- Sperm analysis
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Fertilys
SARS-CoV Infection, Covid19
International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global)
The International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global), is an international registry of approximately 10,000 healthcare workers in low- and middle-income countries experiencing increasing…
- Trial name
- NCT04626076
- Testing
- Comparative Observational Cohort Study
- Where
- Pakistan
- Volunteers
- 6,808 people, healthy volunteers welcome
- Sponsor
- Certara
Post-Viral Fatigue Syndrome
Low-dose Naltrexone for Post-COVID Fatigue Syndrome
This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e.
- Trial name
- NCT05430152
- Testing
- Low-Dose Naltrexone
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Luis Nacul
Covid19, SARS-CoV Infection
Collection of the Thrombo-VaxCov Cohort
In the context of anti-Covid19 vaccination, atypical thrombosis have occured and potential link with vaccination is under investigation.
- Conditions
- Covid19, SARS-CoV Infection, Venous Thrombosis, Thrombocytopenia
- Trial name
- THROMBO-VAXCOV (NCT04889326)
- Testing
- Retrospective data and biological samples
- Where
- France
- Sponsor
- University Hospital, Lille
HIV Infections
Tambua Mapema Plus - to Discover HIV Infection Early and Prevent Onward Transmission
This study will assess the impact of an HIV-1 RNA testing intervention targeting adult patients aged 18-39 years who seek urgent care for symptoms at primary care facilities and meet specific risk criteria for acute HIV…
- Trial name
- TMP (NCT03508908)
- Testing
- HIV-1 RNA testing
- Where
- Kenya
- Volunteers
- 2,887 people
- Sponsor
- University of Oxford