Clinical trials: Acute Infectious Diseases
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Acute Respiratory Infection, Bronchitis
Phase 4 Study - Mucinex D as Adjunct Therapy
The objective of the study is to evaluate the safety and efficacy of Mucinex D tablets in providing symptom relief when administered as an adjunct to antibiotic therapy in patients with acute respiratory infection.
- Conditions
- Acute Respiratory Infection, Bronchitis, Rhinosinusitis
- Trial name
- NCT00441246
- Testing
- Mucinex D (600 mg guaifenesin and 60 mg pseudoephedrine HCl extended-release bi-layer tablets)
- Where
- 28 sites in United States
- Volunteers
- 600 people
- Sponsor
- Adams Respiratory Therapeutics
Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection
Lung Cancer Prevention Screening Programme in Italy
This prospective randomized multicentered clinical study aims at implementing early diagnosis of lung cancer in high-risk heavy smokers in the Italian population.
- Conditions
- Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection, Cardiovascular Diseases
- Trial name
- RISP (NCT05766046)
- Testing
- early lung cancer detection, blood test
- Where
- Italy
- Volunteers
- 7,324 people, healthy volunteers welcome
- Sponsor
- Ugo Pastorino
COVID-19, COVID-19 Respiratory Infection
Low-field Magnetic Resonance Imaging in Pediatric Post Covid-19
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) is a new coronavirus and identified causative agent of COVID-19 disease.
- Conditions
- COVID-19, COVID-19 Respiratory Infection, Long COVID
- Trial name
- FASCINATE (NCT05445531)
- Testing
- Low-field magnetic resonance imaging, Nailfold capillaroscopy, Spiroergometry
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
ME/CFS, Long COVID
LIFT: Life Improvement Trial
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus…
- Conditions
- ME/CFS, Long COVID, PASC
- Trial name
- LIFT (NCT06366724)
- Testing
- Pyridostigmine, Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
Herpes Zoster, Local Infiltration
Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain
Herpes zoster (HZ) is a skin infection disease which cause severe zoster-associated pain (ZAP) along sensory nerve in the corresponding segment.
- Conditions
- Herpes Zoster, Local Infiltration, Acute Pain
- Trial name
- NCT06344403
- Testing
- analgesic, Tender point infiltration
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Beijing Tiantan Hospital
SARS-CoV Infection, Systemic Disease
Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases
An observational study aiming to assess the serological profile of SARS-Cov2 patients with systemic diseases such as systemic lupus erythematosus, Sjogren syndrome, sarcoidosis, inflammatory myopathies, Behçet's disease…
- Conditions
- SARS-CoV Infection, Systemic Disease, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT04530461
- Testing
- Serological test
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- faida agili
HIV Infections
Treatment of Acute HIV Infection to Preserve Immune Function
While most people with HIV experience significant destruction of their immune systems, some people appear to have preserved immune function and can control the virus without drugs.
- Trial name
- NCT00055094
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
SARS-CoV Infection, Vitamin D Deficiency
Influence of Military Preventive Policy for reCruit Training on COVID-19 Seroconversion
This study is intended to address the association between vitamin D status and seroconversion to SARS-CoV-2 in healthy young adults.
- Conditions
- SARS-CoV Infection, Vitamin D Deficiency, Covid19, Acute Respiratory Tract Infection
- Trial name
- IMPACTCOVID (NCT04476680)
- Testing
- Vitamin D
- Where
- 2 sites in United Kingdom
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
COVID-19
Evaluating the Response of the Immune System of People With Long COVID (Post SARS-CoV-2)
Many people who have had COVID 19 continue to experience symptoms long after they have recovered from the acute infection. This study will examine the clinical symptoms of people with "Long COVID" and measure various markers of…
- Trial name
- LCRC (NCT05131594)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Huntington Memorial Hospital
COVID-19
The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19
The purpose of this research study is to assess if glutathione, along with NAC (N-acetyl cysteine) and Alpha lipoic acid (ALA), can help reverse some of the COVID long-haul symptoms.Subjects will be randomized in to one of two…
- Trial name
- NCT05371288
- Testing
- NAC (N-acetyl cysteine), Alpha lipoic acid (ALA), liposomal glutathione (GSH)
- Where
- United States
- Sponsor
- University of California, Irvine
SARS-CoV-2 Infection, COVID-19
Safety and Effects of an Investigational COVID-19 Vaccine as Booster in Healthy People
This was an exploratory Phase I, randomized, observer-blind, active-controlled, dose-escalation trial to evaluate four dose levels (DLs) of BNT162b4 given in combination with BNT162b2 Bivalent (original/Omicron BA.4/BA.5) to…
- Trial name
- NCT05541861
- Testing
- BNT162b2 Bivalent (original/Omicron BA.4/BA.5) 30 mcg, BNT162b4 5 mcg, BNT162b4 10 mcg
- Where
- 17 sites in United States
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Skin Diseases, Bacterial
Safety and Efficacy of CEM-102 Compared to Linezolid in Acute Bacterial Skin Infections
The purpose of this study is to determine the safety and efficacy of CEM-102 compared to Linezolid in the treatment of acute bacterial skin structure infections (ABSSIs).
- Trial name
- NCT00948142
- Testing
- CEM-102, Linezolid
- Where
- 16 sites in United States
- Volunteers
- 198 people
- Sponsor
- Arrevus Inc.
Acute Respiratory Infection
University of Wisconsin Meditation & Exercise Cold Study
The primary goal of this project is to determine whether behavioral training in mindfulness meditation or moderate intensity sustained exercise will lead to reductions in acute respiratory infection (ARI) illness, such as common…
- Trial name
- MEPARI-2 (NCT01654289)
- Testing
- Mindfulness Meditation, Exercise
- Where
- United States
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Common Cold
Testing the Efficacy in Adults With Cold of HEalsea Rescue*
Healsea® Rescue* is a CE-marked class I medical device. This is a saline-based nasal spray supplemented with a natural Symbiofilm™ extract (0.04%) isolated from the marine bacteria.
- Trial name
- TEACHER (NCT05819190)
- Testing
- Healsea Rescue*
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Lallemand Pharma AG
Multiple Sclerosis, NMO Spectrum Disorder
Tongji NADs Cohort
Neurological Autoimmune Diseases (NADs) are disorders caused by abnormal immune system attacks on neural tissues, affecting multiple systems including the central nervous system, peripheral nervous system, and neuromuscular…
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Autoimmune Encephalitis, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
- Trial name
- NCT07333196
- Testing
- No active interventions
- Where
- China
- Volunteers
- 1,550 people
- Sponsor
- Tongji Hospital
Covid19, Post-COVID / Long-COVID
Characterizing Long-term Cognitive and Emotional Impairment in Post-COVID-19 Sequelae
Weeks and months after they have seemingly recovered from COVID-19, many patients continue to suffer from major long-term effects.
- Trial name
- NCT04881305
- Testing
- questionnaires and neuropsychological assessment
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
Guillain Barré Syndrome, Acute Respiratory Failure
Early Mechanical Ventilation for Guillain Barré Syndrome
The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
- Trial name
- NCT00167622
- Testing
- mechanical ventilation, physiotherapy and oxygen if needed
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University of Versailles
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