Clinical trials: Acute Ischaemic Stroke
Acute Ischemic Stroke, Reperfusion Injury
Wet and Dry Biomarkers to Predict Secondary Injury in Stroke: From Bench to Bedside - The NIMBLE Study
Infarct growth (IG), Hemorrhagic Transformation (HT) and Cerebral Edema (CE) can be considered pivotal phenomena of clinical deterioration following an acute ischemic stroke.
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- NIMBLE (NCT07422636)
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- University of Florence
Ischemic Stroke, Intracerebral Hemorrhage
Emergency Stroke Unit for Acute Cerebrovascular Events: A Prospective, Single-arm Trial With a Historical Control Group
Background Reperfusion therapies, i.e., intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), are most effective treatments in the management of acute ischemic stroke (AIS) patients.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Stroke, Stroke, Acute
- Trial name
- ESU-ACE-E (NCT06728592)
- Testing
- Portable Magnetic Resonance Imaging
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Stroke
Evaluation of the ReVive SE Device for Intra-Arterial Thrombectomy in Acute Ischemic Stroke
The main objective of this study is to assess the safety and effectiveness of the ReVive SE (Self- Expanding) Neurothrombectomy Device in subjects requiring mechanical thrombectomy when used according to its Instruction for use…
- Trial name
- Re-ACT (NCT02169492)
- Where
- 8 sites in France
- Volunteers
- 103 people
- Sponsor
- Codman & Shurtleff
Acute Ischemic Stroke
Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke
This is a randomized, placebo-controlled, phase 3 clinical trial to evaluate the efficacy and safety of transcranial ultrasound (US) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute…
- Trial name
- CLOTBUST-ER (NCT01098981)
- Testing
- Transcranial ultrasound as an adjunctive therapy to tPA, Standard of care tPA therapy for acute ischemic stroke
- Where
- United States
- Volunteers
- 675 people
- Sponsor
- Cerevast Therapeutics, Inc.
Stroke, Acute, Transient Ischemic Attack
Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel
The study was designed as a multicenter multiracial prospective observational study of acute ischemic stroke and TIA patients across china.
- Conditions
- Stroke, Acute, Transient Ischemic Attack, Single-gene Disorders
- Trial name
- MDEOS (NCT04485598)
- Where
- China
- Volunteers
- 502 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Type 2 Diabetes
Efficacy and Safety of Urinary Kallidinogenase in the Treatment of Acute Ischemic Stroke Combined With Type 2 Diabetes Mellitus
This study is a multicenter, randomized, double-blind, placebo parallel control study, aim to evaluate the efficacy and safety of human urinary kallidinogenase in the treatment of acute ischemic stroke with type 2 diabetes.
- Trial name
- TK-SEEK (NCT06085378)
- Testing
- Urinary Kallidinogenase for injection
- Where
- China
- Volunteers
- 630 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ischemic Stroke, Stroke
Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke
The primary goal of this trial is to determine if individuals with acute ischemic stroke treated with a medium dose of IV rt-PA plus IV eptifibatide started within 3 hours of symptom onset are more likely to have a better outcome…
- Conditions
- Ischemic Stroke, Stroke, Brain Infarction
- Trial name
- CLEAR-ER (NCT00894803)
- Testing
- Eptifibatide, rt-PA
- Where
- 20 sites in United States
- Volunteers
- 126 people
- Sponsor
- University of Cincinnati
Acute Ischemic Stroke, Intracranial Artery Occlusion
Rescue Stenting for Failed Endovascular Thrombectomy in Acute Ischemic Stroke (ReSET)
This study is a prospective, open-label, multi-center, registry study, designed to show that rescue stenting is safe and effective for emergency large vessel occlusion (ELVO) patients who have mechanical thrombectomy failure.
- Trial name
- NCT03993340
- Testing
- Rescue stenting
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
Bloodletting Puncture in the Treatment of Acute Ischemic Stroke
The bloodletting puncture is an external treatment for acute ischemic stroke by releasing an appropriate amount of blood with a three-edged needle at specific points on the patient's body.
- Trial name
- NCT05266326
- Testing
- Western medicine conventional treatment +Bloodletting puncture, Western medicine conventional treatment
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chongqing Traditional Chinese Medicine Hospital
Acute Ischemic Stroke
Stent Retriever for Thrombectomy Revascularisation of Large Vessel Occlusions in Acute Ischemic Stroke(Catfish)
The study is a randomized, prospective, parallel-group, multicenter, open-label, non-inferiority trial. Patients are randomized 1 : 1 to either stent retriever(Catfish) or Solitaire for endovascular therapy for acute ischemic…
- Trial name
- NCT03820882
- Testing
- Catfish, Solitaire FR
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Ischemic Stroke, Occlusion, Cerebrovascular
Revive AIS Patients ImmeDiately
This is a multicenter, prospective registry clinical study to evaluate the real-world efficacy and safety of intra-arterial treatment for acute ischemic stroke using Revive SE device on the basis of standardised medical treatment.
- Trial name
- RAPID (NCT03007082)
- Testing
- Revive SE intracranial thrombectomy device
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Ischemic Stroke
Chinese Acute Ischemic Stroke Treatment Outcome Registry
This is a multi-center registry study. The investigators will include 10,000 patients with confirmed acute ischemic stroke in China.
- Trial name
- CASTOR (NCT02470624)
- Testing
- treatment following current guideline
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Cerebral Infarction
The Efficacy and Safety Study of ALbumin Therapy in Acute Ischemic Stroke
In this clinical study, the efficacy and safety of ALbumin is to be evaluated for the patients occurred within 12 hours of acute ischemic stroke.
- Trial name
- ALbumin (NCT01684462)
- Testing
- Human Serum Albumin 20, 0.9 % Normal Saline
- Where
- 4 sites in South Korea
- Volunteers
- 2 people
- Sponsor
- Seoul St. Mary's Hospital
Stroke, Practice
Smart-SABI: Digital Phenotyping of Stroke Access Barriers
This study aims to identify and quantify the non-clinical barriers (social, transport, and knowledge-based) that delay patient arrival at the hospital during an Acute Ischemic Stroke.
- Conditions
- Stroke, Practice, Healthcare Disparities, Thrombectomy
- Trial name
- Smart-SABI (NCT07257146)
- Testing
- Targeted Stroke Systems of Care Training (SABI-Guided)
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Acute Ischemic Stroke
ACTISAVE: ACuTe Ischemic Stroke Study Evaluating Glenzocimab Used as Add-on Therapy Versus placEbo
A randomized, double blind, multicenter, multinational, placebo controlled, parallel group, single dose, adaptive phase II/III study.
- Trial name
- ACTISAVE (NCT05070260)
- Testing
- Intravenous glenzocimab (ACT017) 1000 mg
- Where
- 10 sites in United States, Germany
- Volunteers
- 438 people
- Sponsor
- Acticor Biotech
Acute Ischemic Stroke, Ischemic Stroke
Zeit Alert for Stroke at Home (ZASH) Protocol
This is a single-arm, observational, feasibility study to evaluate if the Halo Alert System can be used in the future to detect stroke events in individuals at risk for stroke wearing the Halo Alert System overnight.
- Conditions
- Acute Ischemic Stroke, Ischemic Stroke, Stroke
- Trial name
- ZASH (NCT05669456)
- Testing
- Halo Alert System
- Volunteers
- 300 people
- Sponsor
- Zeit Medical, Inc.
Acute Stroke, Ischemic Stroke
Analysing the Effects of Xingnaojing for Mild-to-severe Acute Ischemic Stroke
The main purpose of this trial is to analyse the Effects of Xingnaojing for Mild-to-severe Acute Ischemic Stroke by Metabonomics, proteomics and clinical parameters.
- Trial name
- NCT04813445
- Testing
- Xingnaojing injection
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Acute Ischemic Stroke
Susceptibility Weighted Imaging for Detection of Thrombus in Acute Ischemic Stroke.
It is a retrospective cross-sectional study, where consecutive stroke patients with vessel occlusion on magnetic resonance angiography (MRA) will be included for the study for one year.
- Trial name
- NCT05738070
- Testing
- Magnetic resonance imaging
- Where
- Nepal
- Volunteers
- 105 people
- Sponsor
- Upendra Devokta Memorial National Institute of Neurology and Allied Scicences
Ischemic Stroke, Acute
Lumbrokinase vs Placebo in Moderate-to-Severe Ischemic Stroke
LUMEN is a multicenter, randomized, double-blind, placebo-controlled superiority trial designed to evaluate whether oral lumbrokinase enteric-coated capsules combined with aspirin improve functional outcomes compared with aspirin…
- Trial name
- NCT07763405
- Testing
- Lumbrokinase
- Volunteers
- 1,196 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Stroke
Low-dose Versus Standard Dose Alteplase in Acute Ischemic Stroke , 4 Monthes Prospective Study
Cohort A Randomized Control trial of Ateplase 0.6, 0.75 and 0.9 mg/kg in 78 patients Cohort B single arm 0.9 mg/kg Ateplase in 330 patients Combined Cohort A and B evaluate different of death, intra-cerebral hemorrhage, numberof…
- Trial name
- NCT03847883
- Testing
- Intravenous Solution Ateplase
- Where
- Thailand
- Volunteers
- 408 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand