Clinical trials: Acute Ischaemic Stroke
Acute Stroke
Danhong Injection in the Treatment of Acute Ischemic Stroke
The purpose of this study is to determine whether Danhong injection is effective in the treatment of acute ischemic stroke.
- Trial name
- NCT01677208
- Testing
- Danhong injection, Standard medical care
- Where
- 62 sites in China
- Volunteers
- 1,503 people
- Sponsor
- China Academy of Chinese Medical Sciences
Stroke, Ischemic, Anesthesia
Anaesthesia for Mechanical Thrombectomy
Title: Conduct of anaesthesia during acute ischaemic stroke: a retrospective case series of patients undergoing mechanical thrombectomy. Design: This study will be a retrospective consecutive observational case series
- Trial name
- NCT04804085
- Volunteers
- 250 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Acute Ischemic Stroke
Evaluation Of HUK in Acute Stroke Patients: MRS and CTP
Background: Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality worldwide. Human urinary kallidinogenase (HUK), a glycoprotein extracted from male urine currently used in China for enhancing cerebral…
- Trial name
- NCT03431909
- Testing
- Human urinary kallidinogenase (HUK), aspirin® , clopidogrel® , atorvastatin®
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Efficacy and Safety of Early Initiation of Butylphthalide Treatment in Patients With Acute Ischemic Stroke.
This study is a prospective, multicenter, randomized, open-label, blinded-endpoint trial designed to evaluate the difference in efficacy of Butylphthalide Sodium Chloride Injection treatment initiated early (\<3 hours) versus…
- Trial name
- NCT06472921
- Testing
- Butylphthalide treatment initiation time
- Where
- 2 sites in China
- Volunteers
- 204 people
- Sponsor
- Xiangya Hospital of Central South University
Ischemic Stroke
Asia Africa Streptokinase Trial
Currently, thrombolysis is offered to less than 1% of patients in low to middle income countries (LMICs) where access to health care is often based on the financial capabilities of the patient.
- Trial name
- AASIST (NCT02150785)
- Testing
- Streptokinase
- Sponsor
- University of Alberta
Ischemic Stroke
Atorvastatin in Acute Stroke Treatment
Recent clinical trials and meta-analyses of b-hydroxy-bmethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have demonstrated a significant reduction in ischemic stroke in patients with a history of coronary artery…
- Trial name
- NCT02225834
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Ischemic Stroke
Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients
The purpose of this study is to determine whether remote ischemic postconditioning (RIPostC) initiates autonomic nervous system response and affects the prognosis in patients with acute ischemic stroke.
- Trial name
- IRAS (NCT02777099)
- Testing
- remote ischemic postconditioning
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Ischemic Stroke, Atrial Fibrillation Symptomatic
Cerebral Microbleeds During NOACs or Warfarin Therapy in NVAF Patients With Acute Ischemic Stroke (CMB-NOW)
Anticoagulants are generally recognized as a necessary therapy to prevent the recurrence of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF), but in some patients they also cause bleedings, particularly…
- Trial name
- CMB-NOW (NCT02356432)
- Where
- 3 sites in Japan
- Volunteers
- 86 people
- Sponsor
- Tokai University
Ischemic Stroke, Acute, Ischemia-reperfusion Injury
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury
The study is a two-center prospective cohort clinical trial. The primary purpose of this trial is to identify the pattern of DKK2 serum levels in ischemic stroke patients after revascularization therapy and determine the…
- Conditions
- Ischemic Stroke, Acute, Ischemia-reperfusion Injury, Cerebral Edema
- Trial name
- NCT05585255
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ischemic Stroke
Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow.
- Trial name
- NCT02056821
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Henry Ford Health System
Ischemic Stroke, Acute, Stroke
NeuroGlove fMRI Study
This is a prospective, single center, interventional clinical study containing two cohorts the treatment cohort and control cohort. A total of 13 subjects will be enrolled.
- Trial name
- NCT05961293
- Testing
- NeuroGlove
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroGlove LLC
Ischemic Stroke
IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion
Stroke is the third leading cause of death in the United States, responsible for 158,488 deaths in 1998 (American Heart Association). Nationwide, each year, an estimated 600,000 to 750,000 people suffer a new or recurrent stroke.
- Trial name
- NCT00624000
- Testing
- IV tpa (Alteplase) vs IA tpa (Alteplase)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Ischemic Stroke
Study to Assess PK, Safety and Tolerability Early in Healthy Subjects
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of QHRD106 early in Chinese healthy subjects with single doses.
- Trial name
- NCT06388772
- Testing
- QHRD106 Injection
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Changzhou Qianhong Bio-pharma Co., Ltd.
Ischemic Stroke, Atrial Fibrillation
Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)
The proposed study will validate the clinical use of new biomarker blood tests to identify blood components that may differentiate between diverse stroke etiologies and clinical outcomes as listed below: 1.
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Transient Ischemic Attacks, Transient Cerebrovascular Events
- Trial name
- BASE (NCT02014896)
- Testing
- Biomarker blood draw
- Where
- 22 sites in United States
- Volunteers
- 1,750 people
- Sponsor
- Ischemia Care LLC
Ischemic Stroke
Argatroban Stroke Treatment - A Pilot Safety Study
Is the combination of low doses of argatroban in combination with rt-PA safe, and does it increase recanalization in patients with acute ischemic stroke.
- Trial name
- NCT00268762
- Testing
- argatroban
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ischemic Stroke
AdminiStration of Statin On Acute Ischemic stRoke patienT Trial
Investigators will study whether immediate statin treatment after the onset of stroke is beneficial on the neurological protection
- Trial name
- ASSORT (NCT02549846)
- Testing
- Statin
- Where
- Japan
- Volunteers
- 270 people
- Sponsor
- Hyogo Medical University
Cerebrovascular Accident
EARLY 3-months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA
German stroke units are hesitating to use Aggrenox for secondary ischaemic stroke / transient ischaemic attack (TIA) prevention in a sub-acute treatment setting.
- Trial name
- NCT00562588
- Testing
- Aggrenox bid (ASA 25mg/Dipyridamole ER 200mg), ASA 100 mg qd
- Where
- Germany
- Volunteers
- 551 people
- Sponsor
- Boehringer Ingelheim
Stroke, Ischemic
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke is a multi-centers registration. It starts in Jan 2019. The key items in the registration form include basic demographic profiles, past medical history, time…
- Trial name
- TREAT-AIS (NCT05281055)
- Testing
- Endovascular thrombectomy
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- National Taiwan University Hospital
Stroke, Stroke, Acute
Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery
Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke, Hemorrhagic
- Trial name
- APS-PILOT (NCT06575140)
- Testing
- Associative Peripheral Stimulation (APS) 1.0, Peripheral Neuromuscular Stimulation
- Where
- 3 sites in Mexico
- Volunteers
- 20 people
- Sponsor
- Ahmed A. Rahim
Stroke, Acute Ischemic Stroke
Repinotan in Patients With Acute Ischemic Stroke
The purpose of this trial is to evaluate Repinotan HCl in patients with acute ischemic stroke. At study entry patients will be randomized to Repinotan HCl or placebo in a 1:1 ratio. The total treatment period wil be 72 hours.
- Trial name
- NCT00044915
- Testing
- Repinotan HCl (BAYX3702)
- Where
- 119 sites in United States, Australia and 13 more
- Volunteers
- 782 people
- Sponsor
- Bayer