Clinical trials: Acute Ischemia
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Myocardial Infarction, Acute Coronary Syndrome
Study to Evaluate the Care Process and the Quality of STEMI Care
Cardiovascular diseases, and more precisely patients with ST - elevated myocardial infarction are globally responsible for a large number of hospitalizations and deaths.
- Trial name
- CP4ACS (NCT02961777)
- Testing
- implementation of care pathway
- Volunteers
- 640 people
- Sponsor
- European Pathway Association
Acute Coronary Syndromes
Knowledge Translation for Patients With Acute Coronary Syndromes
Cluster randomized open-label experimental study multi-center of 24 hospitals to either knowledge translation vs usual care to improve care of patents hospitalized for acute coronary syndromes.
- Trial name
- AMI-OPTIMA (NCT02672137)
- Testing
- knowledge translation
- Volunteers
- 4,604 people
- Sponsor
- Montreal General Hospital
Acute Ischemic Stroke
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic…
- Trial name
- PEACE (NCT06139692)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 4 sites in China
- Volunteers
- 810 people
- Sponsor
- Jinling Hospital, China
Stroke, Acute, Intracerebral Hemorrhage
The Akershus Study of Ischemic Stroke and Thrombolysis -1
This observational study comprises consecutively patients with cerebrovascular diseases admitted to the Stroke Unit at Akershus University Hospital in Norway.
- Conditions
- Stroke, Acute, Intracerebral Hemorrhage, Stroke, Ischemic, TIA
- Trial name
- ASIST-1 (NCT05378490)
- Where
- Norway
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Akershus
Ischemic Stroke
Serial ECG Versus Holter to Detect Atrial Fibrillation in Elderly Ischemic Stroke Patients
Paroxysmal atrial fibrillation is often undetected because characteristics such as short duration, episodic, and frequently asymptomatic nature make it challenging to diagnose at the bedside, leading to suboptimal secondary…
- Trial name
- NCT02578979
- Testing
- Electrocardiogram, Holter
- Where
- 6 sites in Taiwan
- Volunteers
- 826 people
- Sponsor
- Chang Gung Memorial Hospital
Myocardial Infarction
Ex Vivo Cultured Bone Marrow Derived Allogenic MSCs in AMI
This clinical trial aims to find out the safety and efficacy of adult mesenchymal stem cells in patients with myocardial infarction.
- Trial name
- NCT00883727
- Testing
- Stem cell, Plasmalyte A
- Where
- 4 sites in India
- Volunteers
- 20 people
- Sponsor
- Stempeutics Research Pvt Ltd
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )
To compare the prognosis of patients with hyperacute ischemic stroke (arriving at the emergency department between 4.5-6 hours of symptom onset) managed in a standard stroke unit adherent to guidelines versus managed in Emergency…
- Trial name
- NCT06522282
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Large Vessel Occlusion, Acute Ischemic Stroke
Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort
This multicenter, ambispective cohort study establishes a comprehensive multiomics biobank from five stroke centers, encompassing thrombi, intracranial blood, peripheral arterial/venous blood, and…
- Trial name
- CLOMB (NCT06963489)
- Testing
- Not applicable- observational study
- Where
- 5 sites in China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion
New Non-invasive Modalities for Assessing Retinal Structure and Function
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other…
- Conditions
- Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy
- Trial name
- NCT03475173
- Testing
- LSFG-NAVI
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Ischemic Stroke, Acute, Thrombectomy
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process.
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation
- Trial name
- COMET-AIS (NCT05051397)
- Testing
- HYPERCAPNIA, NORMOCAPNIA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Arterial Stiffness, Endothelial Function
Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System
Myocardial infarction is related with endothelial function, arterial stiffness and autonomic nervous system dysfunction, but also with arterial hypertension.
- Conditions
- Arterial Stiffness, Endothelial Function, Autonomic Nervous System, Acute Coronary Syndrome
- Trial name
- FOREVER (NCT02195388)
- Testing
- comprehensive cardiac rehabilitation
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lodz
Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with…
- Trial name
- NCT03734640
- Testing
- Low-intensity monitoring strategy, Guideline recommended standard monitoring
- Where
- 54 sites in United States, Australia and 5 more
- Volunteers
- 4,922 people
- Sponsor
- Craig Anderson
Acute Coronary Syndrome
Pre-hospital Rule-out of Acute Coronary Syndrome
Patients with chest pain suspected for non ST-segment elevation acute coronary syndrome (NSTE-ACS) are routinely transferred to the emergency department (ED).
- Trial name
- ARTICA (NCT05466591)
- Testing
- Pre-hospital rule-out strategy
- Where
- Netherlands
- Volunteers
- 866 people
- Sponsor
- Radboud University Medical Center
Dysphagia
Non-standardized vs. Standardized Screening for Dysphagia
The purpose of this study is to compare two different screening tests for detecting dysphagia (difficulty swallowing) as well as the risk for aspiration (silent swallowing of liquids/solids into the lungs) in patients after an…
- Trial name
- NCT05603897
- Testing
- Mann Assessment of Swallowing Ability (MASA) (dysphagia screening tool), Non-standardized clinical swallow evaluation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Stroke
A Multicenter, Retrospective, Observational Cohort Study on Intravenous Thrombolysis Beyond the Time Window for Acute Ischemic Stroke
A multicenter, retrospective, observational cohort study on intravenous thrombolysis beyond the time window for acute ischemic stroke
- Trial name
- TRAILBLAZER (NCT07419997)
- Where
- China
- Volunteers
- 2,600 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Quality Assessment in Acute Stroke Care
The purpose of the study is to evaluate the quality of care on a 16 bed stroke unit by using a new developed clinical pathway.
- Trial name
- QuASt (NCT00574262)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Muenster
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca
Stroke, Endovascular Treatment
Endovascular treatmenT for Acute Ischemic Stroke in China
This is a retrospective real world registry study, aiming to explore the effectiveness and safety of endovascular treatment of acute ischemic stroke in a Chinese population.
- Trial name
- DETECT-China (NCT04752735)
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- General Hospital of Shenyang Military Region