Clinical trials: Acute Ischemic Stroke Patients
Acute Ischemic Stroke
Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL)
This study is an investigator-initiated Phase 1b clinical trial employing an open-label, non-randomized, dose-escalation design.
- Trial name
- HEAL (NCT07513233)
- Testing
- Anisodine Hydrobromide
- Where
- 10 sites in China
- Volunteers
- 92 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, AIS
A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke
Study Methods: The trial consists of two phases, both including a placebo control. Phase Ia (single-dose, dose-escalation): Three dose groups (low, medium, high) are set.
- Trial name
- NCT07628933
- Testing
- Human Umbilical Cord Mesenchymal Stem Cells Injection
- Where
- China
- Volunteers
- 35 people
- Sponsor
- BOE Technology Group Co., Ltd.
Stroke Acute
Adjuvant Cerebroprotection Using Normobaric Hyperoxia in Pre-hospital Patients with Suspected Stroke
The primary objective of this study is to determine the efficacy and safety of inhaled normobaric hyperoxia therapy (NBO) beginning in the pre-hospital setting in patients with suspected acute cerebral ischemia (ACI) due to large…
- Trial name
- AN-O2-EMS (NCT06801457)
- Testing
- NBO, Control
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)
The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours.
- Trial name
- NCT00044057
- Testing
- YM872 (zonampanel), t-PA (alteplase)
- Where
- 118 sites in United States, Austria and 3 more
- Sponsor
- Astellas Pharma Inc
Acute Ischemic Stroke
A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients
This study tests the drug, Plasmin (Human), in patients with a stroke due to a clot in the middle cerebral artery (MCA). Plasmin is an enzyme that causes clot lysis by cleaving a clot component, fibrin.
- Trial name
- NCT01014975
- Testing
- Plasmin (Human)
- Where
- 23 sites in Australia, Austria and 4 more
- Volunteers
- 40 people
- Sponsor
- Grifols Therapeutics LLC
Ischemic Stroke
Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies
Phase II, prospective, randomized, multicenter, open-label, pilot clinical trial comparing remote ischemic conditioning (RIC) plus standard medical therapy to standard medical therapy alone, in patients with acute ischemic stroke…
- Trial name
- TRICS-9 (NCT04400981)
- Testing
- Remote ischemic conditioning, standard medical therapy
- Where
- 4 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca
Stroke, Acute Ischemic
Effectiveness of Yangxue Qingnao Granules in Preventing Post Thrombolytic Hemorrhage Transformation in Patients With Acute Cerebral Infarction
Evaluate the effectiveness of Yangxue Qingnao Granules in preventing post thrombolytic hemorrhage transformation in patients with acute cerebral infarction, and explore its possible mechanism
- Trial name
- NCT06344312
- Testing
- Yangxue Qingnao Granules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Ischemic Stroke
The Benefit of Add On DLBS1033 for Ischemic Stroke Patient
Stroke is one of the most common non-communicable diseases worldwide. It is the leading cause of morbidity and mortality in many countries. Stroke is broadly classified into ischemic and hemorrhagic stroke.
- Trial name
- NCT04425590
- Testing
- DLBS1033, Aspirin, Statin
- Where
- Indonesia
- Volunteers
- 180 people
- Sponsor
- Duta Wacana Christian University
Ischemic Stroke, Intracerebral Haemorrhage
Head Position in Stroke Trial (HeadPoST)
This study is an investigator-initiated and conducted, international collaborative, regionally organised, multicentre, prospective, cluster randomised, crossover, blinded outcome assessment study to compare the effectiveness of…
- Trial name
- HeadPoST (NCT02162017)
- Testing
- The lying flat (0°) head position for 24 hours, The sitting-up (≥30°) head position for 24 hours
- Where
- Australia
- Volunteers
- 11,096 people
- Sponsor
- The George Institute
Stroke, Ischemic Stroke
Intravenous Magnesium Sulphate in Acute Ischemic Stroke
Magnesium has a neuroprotective role so the investigators aim to evaluate the role of intravenous magnesium sulphate in improving the clinical outcomes as assessed by the NIH Stroke Scale (NIHSS) in patients with acute ischemic…
- Trial name
- NCT04412850
- Testing
- Magnesium Sulfate
- Volunteers
- 44 people
- Sponsor
- Dow University of Health Sciences
Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle
The design of the present study will be a multicenter prospective observational protocol. Approximately 100 patients will be recruited over the 24-month period with Acute Brain Injury (trauma brain injury, intracerebral…
- Conditions
- Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Trauma, Brain, Hypertension Intracranial
- Trial name
- CLOSED (NCT06057155)
- Testing
- ultrasound optic nerve sheath diameter assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Ischemic Stroke, Acute
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke
The aim of this study was to evaluate the efficacy and safety of Minocycline versus placebo in the treatment of patients with moderate to severe acute ischemic stroke.
- Trial name
- EMPHASIS (NCT05836740)
- Testing
- Minocycline hydrochloride capsule
- Where
- 58 sites in China
- Volunteers
- 1,724 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute, Stroke, Ischemic
HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN)
This study aims to address the existing clinical challenges by introducing high-resolution magnetic resonance vessel wall imaging (HR-MRI), an advanced imaging technology, to achieve precise etiological classification in patients…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Cerebral Infarction
- Trial name
- NCT07379190
- Testing
- Tirofiban, dual antiplatelet therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Weifang Medical University
Cerebrovascular Accident
Safety and Efficacy of NeuroFlo in 8-24 Hour Stroke Patients
The purpose of this study is to assess the safety and feasibility of the NeuroFlo™ catheter in treating patients with ischemic stroke whose last time symptom-free was between 8-24 hours prior to treatment.
- Trial name
- Flo 24 (NCT00436592)
- Testing
- NeuroFlo™ Catheter
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 26 people
- Sponsor
- CoAxia
Stroke, Acute, Stroke, Ischemic
Robotic Rehabilitation Treatment of Stroke Patients
Storke results in severe deterioration in quality of life and exercise. Severe disorders need to be treated as soon as possible and they need to be rehabilitated quickly in order for motor functions to develop properly.
- Trial name
- NCT05300867
- Testing
- Neurorehabilitation, Physiotherapy
- Where
- Hungary
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Ischemic Stroke
Atorvastatin in Acute Stroke Treatment
Recent clinical trials and meta-analyses of b-hydroxy-bmethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have demonstrated a significant reduction in ischemic stroke in patients with a history of coronary artery…
- Trial name
- NCT02225834
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Remote Ischemic Postconditioning
Influence of Bilateral Arm Ischemic Postconditioning on Clinical Prognosis and Outcome in Acute Ischemic Stroke Patients
Influence of bilateral arm ischemic postconditioning （BAIPC）on the injury and protective blood markers and the clinical prognosis and outcome in patients with acute ischemic stroke
- Trial name
- BAIPC (NCT03335111)
- Testing
- Remote Ischemic Conditioning Equipment, Intravenous blood collection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Jilin University
Brain Ischemia, Stroke Rehabilitation
Time Window for Ischemic Stroke First Mobilization Effectiveness
Early mobilization was thought to be effective in patients with acute ischemic stroke. As the essential component of stroke unit care, early mobilization has already been part of routine clinical practice.
- Trial name
- TIME (NCT03938311)
- Testing
- early rehabilitation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China Stroke Databank Center
Acute Ischemic Stroke
Effect of Body Position on Hemodynamics in Patients With Acute Ischemic Stroke Undergoing Ultra-early Reperfusion Therapy
The aim of this study was to determine the differences in hemodynamics between different positions in patients undergoing ultra-early reperfusion therapy.
- Trial name
- NCT05618535
- Testing
- Transcranial Doppler.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Cerebral Stroke, Ischemic Attack, Transient
Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 will reduce functional disability from an acute stroke. The study is designed to look at both overall recovery and recovery of motor function, for example muscle strength and coordination.
- Trial name
- NCT00119626
- Testing
- NXY-059
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 1,700 people
- Sponsor
- AstraZeneca