Clinical trials: Acute Ischemic Stroke Patients
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Acute Ischemic Stroke
Efficacy and Safety of PCSK9 Inhibitors in Patients With Large-Artery Atherosclerosis (LAA) Ischemic Stroke
This prospective multicenter cohort study aims to evaluate the effectiveness and safety of early PCSK9 inhibitor therapy in patients with large-artery atherosclerotic ischemic stroke.
- Trial name
- NCT07540741
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Acute Ischemic Stroke, Partial Anterior Circulation Infarct
DLBS1033 for Acute Ischemic Stroke Patients
This is a prospective, randomized, double-blind, and controlled clinical study to investigate the effects of DLBS1033 in conjunction with standard therapy compared to standard therapy alone in acute ischemic stroke patients.
- Conditions
- Acute Ischemic Stroke, Partial Anterior Circulation Infarct, Lacunar Anterior Circulation Infarct
- Trial name
- ADDLIST (NCT02133521)
- Testing
- DLBS1033
- Where
- 10 sites in Indonesia
- Volunteers
- 80 people
- Sponsor
- Dexa Medica Group
Ischemic Stroke, Acute, Ischemic Stroke
A Dose-Response Controlled Trial of Bevifibatide for Acute Ischemic Stroke
BCAIS-I is a single-center, randomized, double-blind, dose-response controlled clinical Trial, to preliminarily explore the efficacy of two different maintenance doses of bevifibatide citrate injection in improving 90-day…
- Conditions
- Ischemic Stroke, Acute, Ischemic Stroke, Cerebral Infarction, Brain Diseases
- Trial name
- BCAIS-I (NCT06712004)
- Testing
- Bevifibatide citrate injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
Acute Ischemic Stroke
Efficacy and Safety of the KPCXM18 Injection in Patients With Acute Ischemic Stroke
This study is a multicenter, randomized, double-blind, parallel, placebo-controlled trial design to evaluate the efficacy and safety of the KPCXM18 injection at different doses for the treatment of acute ischemic stroke.
- Trial name
- KPCXM18 (NCT07279493)
- Testing
- The KPCXM18 injection
- Where
- 23 sites in China
- Volunteers
- 300 people
- Sponsor
- Kunming Pharmaceuticals, Inc.
Acute Ischemic Stroke
Predictive Significance of TEG on END in Patients With Acute Ischemic Stroke
The purpose of this study is to evaluate whether Thromboelastography (TEG) parameters on admission might be predictive for early neurological deterioration in acute ischemic stroke patients, specifically for the DWI lesion…
- Trial name
- NCT03310931
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongguan People's Hospital
Acute Ischemic Stroke, Coronary Artery Disease
Cardiac CT Angiography in Patients With Acute Ischemic Stroke
Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular…
- Trial name
- ACUTE (NCT06176872)
- Testing
- Cardiac Computed Tomography Angiography
- Volunteers
- 165 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Ischemic Stroke
Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke
The hypothesis of this study is that "the poor metabolizer or intermediate metabolizer of the cytochrome P450 2C19 genotype in patients with acute ischemic stroke is associated with increased risk of composite cardiovascular…
- Trial name
- NCT04072705
- Testing
- General principles of care and judgement of researcher
- Where
- 37 sites in South Korea
- Volunteers
- 2,927 people
- Sponsor
- Gangnam Severance Hospital
Dysphagia
Non-standardized vs. Standardized Screening for Dysphagia
The purpose of this study is to compare two different screening tests for detecting dysphagia (difficulty swallowing) as well as the risk for aspiration (silent swallowing of liquids/solids into the lungs) in patients after an…
- Trial name
- NCT05603897
- Testing
- Mann Assessment of Swallowing Ability (MASA) (dysphagia screening tool), Non-standardized clinical swallow evaluation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Stroke, Ischemic Attack, Transient
Platelet Reactivity in Acute Non-disabling Cerebrovascular Events
Ticagrelor is a reversible and direct-acting oral antagonist of the P2Y12 (Purinergic receptor P2Y, G-protein coupled, 12) receptor for adenosine diphosphate, which provides faster, greater, and more consistent P2Y12 inhibition…
- Trial name
- PRINCE (NCT02506140)
- Testing
- Ticagrelor and Acetylsalicylic acid, Clopidogrel and Acetylsalicylic acid
- Where
- 25 sites in China
- Volunteers
- 675 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Heparin for RAO Post-Transradial Angiography in AIS
Cerebral angiography is a critical diagnostic tool in neurology, serving as the "gold standard" for evaluating cerebrovascular stenosis, hemodynamics, aneurysms, and arteriovenous malformations.
- Trial name
- NCT07162064
- Testing
- Heparin - Therapeutic dosage, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Xiang Luo
Anesthetic Complication
Anesthetic Complication Among Acute Ischemic Stroke Patients During Endovascularization Therapy
Retrospective descriptive study
- Trial name
- NCT03426917
- Where
- Thailand
- Volunteers
- 93 people
- Sponsor
- Mahidol University
Acute Ischemic Stroke AIS, Stroke Treatment
CardioLogical Interventions and Acute strOke Treatment sTudy
The study aims to investigate characteristics and prognosis of ischemic stroke cases following cardiological interventions, focusing on the effectiveness and safety of acute ischemic stroke treatments.
- Conditions
- Acute Ischemic Stroke AIS, Stroke Treatment, PCI Patients, Aortic Valve Replacement
- Trial name
- CLOT (NCT07314476)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of L'Aquila
Acute Stroke, Thrombolytic Therapy
Evaluation of the Effectiveness of Thrombolytic Therapy in Acute Ischemic Stroke Patients Using NIRS
Investigators aim to study effectiveness of systemic thrombolytic therapy on acute ischemic stroke patients with near infrared spectroscopy.
- Conditions
- Acute Stroke, Thrombolytic Therapy, Stroke, Ischemic
- Trial name
- E-NESE (NCT03621917)
- Testing
- Near-infrared spectroscopy reading
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Dokuz Eylul University
Ischemic Stroke, High Blood Pressure
Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)
ENCHANTED is an independent, investigator initiated, international collaborative, quasi-factorial randomised controlled trial involving a package of 2 linked comparative randomised treatment arms, which aims to address 4 key…
- Trial name
- ENCHANTED (NCT01422616)
- Testing
- Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering
- Where
- Australia
- Volunteers
- 4,587 people
- Sponsor
- The George Institute
Stroke, Stroke Acute
Accelerating Referral for Thrombectomy in Acute Stroke Patients Using an Artificial Intelligence-based Software
The goal of this clinical trial is to learn if an AI-based imaging software, Methinks Stroke Suite, can reduce the time to transfer stroke patients who need thrombectomy from local stroke centers to specialized centers.
- Conditions
- Stroke, Stroke Acute, Ischemic Stroke, Acute, Thrombectomy
- Trial name
- CATalyze-AI (NCT06741332)
- Testing
- Methinks software, Normal CT scans evaluation
- Where
- 2 sites in Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Ischemic Stroke
Effect of DIRECT Transfer to ANGIOsuite on Functional Outcome in Severe Acute Stroke
Rationale: Acute large-vessel strokes, requiring endovascular treatment, are currently being managed through radiology department before being transferred to the angiography room.
- Trial name
- DIRECTANGIO (NCT03969511)
- Testing
- direct angio-suite admission, standard management
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Sleep-Disordered Breathing, Sleep Architecture
Screening of OSA in Hospitalized Stroke Patients Using BSP
Obstructive sleep apnea (OSA) is prevalent in patients with stroke and has a negative effect on outcomes by predisposing them to recurrent stroke, increasing mortality, and so forth.
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Stroke, Acute
- Trial name
- NCT05466864
- Testing
- Belun Sleep platform
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Ischemic Stroke
Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke
The purpose of this study is to assess the safety and efficacy of early administration of tirofiban in patients treated with tenecteplase for acute ischemic stroke.
- Trial name
- INSTANT (NCT05604638)
- Testing
- Tirofiban Hydrochloride
- Where
- 38 sites in China
- Volunteers
- 348 people
- Sponsor
- Second Affiliated Hospital of Guangxi Medical University
Stroke, Acute Ischemic Stroke
Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)
COOLHEAD-2b is a multicentre, phase 2, prospective, randomised, controlled, open-label, blinded-endpoint trial evaluating the safety and efficacy of non-invasive convective head cooling as an adjunct to endovascular thrombectomy…
- Conditions
- Stroke, Acute Ischemic Stroke, Brain Ischemia, Ischaemic Stroke
- Trial name
- COOLHEAD-2B (NCT07526649)
- Testing
- Non-invasive convective head cooling, Standard of Care (SOC)
- Where
- New Zealand
- Volunteers
- 182 people
- Sponsor
- Auckland City Hospital