Clinical trials: Acute Ischemic Stroke Patients
Acute Ischemic Stroke
Evaluation of Functional Recovery of Patients With Acute Ischemic Stroke Treated by Thrombectomy
The management of cerebral infarctions (CI) is a real public health issue. The French National Authority for Health recommends Mechanical Thrombectomy (MT) either in combination with Intravenous Thrombolysis (IVT), or alone…
- Trial name
- EPIC (NCT04916782)
- Testing
- Quality of life Questionnaire
- Where
- France
- Volunteers
- 540 people
- Sponsor
- University Hospital, Montpellier
Acute Ischemic Stroke
SY007 in Patients With Acute Ischemic Stroke
This Phase 1b multiple center, randomized, double-blind, placebo-controlled study is a dose escalation trial evaluating the safety, tolerability, PK characteristics and efficacy of SY-007 after injection in acute ischemicstroke…
- Trial name
- NCT04891913
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Acute Ischemic Stroke
Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke
This study is a randomized controlled, open-label, blinded endpoint trial. The investigators aim to assess the efficacy and safety of home-based structured physical exercise in participants with acute ischemic stroke.
- Trial name
- HOPE-STROKE 2 (NCT07271082)
- Testing
- Exercise intervention
- Where
- 6 sites in China
- Volunteers
- 208 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke. The Bochumer CRISP Study
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01843361)
- Where
- Germany
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Ischemic Stroke
iTBS for Acute Ischemic Stroke After Thrombectomy
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic…
- Trial name
- NCT06941961
- Testing
- intermittent theta burst stimulation
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Yi Yang
Ischemic Stroke
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
The study investigated the clinical efficacy and safety of a 10-day course of therapy with daily intravenous administration of 30mL Cerebrolysin based on a comparison with Placebo in patients with acute ischemic stroke.
- Trial name
- CASTA (NCT00868283)
- Testing
- Cerebrolysin, 0.9% Saline Solution
- Where
- 49 sites in China, Hong Kong and 1 more
- Volunteers
- 1,071 people
- Sponsor
- Ever Neuro Pharma GmbH
Stroke, Ischemic Stroke
Efficacy of Diterpene Ginkgolides Meglumine Injection in Elderly Patients With Ischemic Stroke
A randomized positived-controlled study of Diterpene Ginkgolides Meglumine Injection (DGMI) vs Ginaton in patients with ischemic stroke (IS) was conducted between7/2013 and 4/2014.
- Conditions
- Stroke, Ischemic Stroke, Nervous System Diseases, Cerebral Infarction
- Trial name
- NCT05169450
- Testing
- Diterpene ginkgolides meglumine injection, Ginaton
- Where
- China
- Volunteers
- 998 people
- Sponsor
- Dongzhimen Hospital, Beijing
Stroke, Cerebral Venous System
Study of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
The VAST study is a single-center prospective observational study that enrolled individuals with acute ischemic stroke (AIS) within 24 hours onset.
- Conditions
- Stroke, Cerebral Venous System, Reperfusion Injury
- Trial name
- VAST (NCT03838289)
- Testing
- multimodal magnetic resonance imaging or computed tomography
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke, Acute
Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke
Early antiplatelet therapy is promising for further improvement of functional prognosis on the basis of intravenous thrombolytic therapy.
- Trial name
- TAPIS (NCT06316570)
- Testing
- Early Dual Antiplatelet Therapy
- Where
- 60 sites in China
- Volunteers
- 1,382 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic, PCSK9 Inhibitor
The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile
The goal of this clinical trial is to test the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitors) in acute ischemic stroke patients associated with atherosclerosis by investigating 1.
- Trial name
- NCT06083961
- Testing
- Alirocumab
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Sun U. Kwon
Acute Ischemic Stroke
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Stroke occurs when a blood clot causes a blockage in a blood vessel (artery) within the brain. This type of stroke is called an ischemic stroke and carries a high risk of disability or death. Stroke must be treated very fast.
- Trial name
- ESCAPE-MeVO (NCT05151172)
- Testing
- endovascular thrombectomy (EVT), Standarad medical care
- Where
- 53 sites in United States, Canada and 2 more
- Volunteers
- 530 people
- Sponsor
- Dr. Michael D Hill
Acute Ischemic Stroke AIS
A Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Intravenous Infusion of hUC-MSCs in Patients With AIS
This is a Phase IIa clinical trial with a three-arm design that utilizes randomization, double-blinding, and placebo control. The primary objective of this study is to evaluate the efficacy of single and multiple intravenous…
- Trial name
- NCT07084012
- Testing
- hUC-MSCs treatment (high dose), hUC-MSCs treatment (low dose)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Wingor Biotechnology Co., Ltd.
Ischemic Stroke
Evaluation of IL-33 in Patients With the Acute Ischemic Stroke
Aim of the study is to evaluate the usefulness of interleukin 33 in the blood plasma in patients with the acute ischemic stroke of the brain in relation to mode of treatment (thrombolysis, thrombectomy, no treatment), risk…
- Trial name
- NCT03948802
- Testing
- Interleukine 33 test in blood plasma
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jan Biziel University Hospital No 2 in Bydgoszcz
Acute Ischemic Stroke, Atrial Fibrillation
Adding Antiplatelet During Edoxaban Treatment in Stroke Patients With Non-valvular Atrial Fibrillation (ADD-ON)
This study aims to compare the effectiveness and safety regarding treatment with standard anticoagulant only or adding antiplatelet to anticoagulant in patients with non-valvular atrial fibrillation and significant…
- Conditions
- Acute Ischemic Stroke, Atrial Fibrillation, Extracranial Atherosclerosis, Intracranial Atherosclerosis
- Trial name
- (ADD-ON) (NCT04010955)
- Testing
- Edoxaban Monotherapy
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Asan Medical Center
Acute Stroke, Anxiety Disorders
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
In fact theWorld Health Organization estimates that 2-3% in general populations of countries across the world tend to be affected by severe mental disorders (1) Thrombolytic therapy seems to be of great importance in achieving…
- Conditions
- Acute Stroke, Anxiety Disorders, Depression
- Trial name
- NCT04484558
- Testing
- Actilyse
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Ischemic Stroke
Study of Efficacy and Safety of MEXIDOL® in Ischemic Stroke Therapy
The purpose of this study is to evaluate the efficacy and safety of long-term sequential therapy with Mexidol® in long-term sequential treatment of patients in the acute and early recovery periods of hemispheric ischemic stroke…
- Trial name
- EPICA (NCT02793687)
- Testing
- Mexidol
- Where
- 11 sites in Russia
- Volunteers
- 150 people
- Sponsor
- Pharmasoft
Ischemic Stroke, Acute
Signal Intensity Gradient in Cerebral Arteries
Arterial wall shear stress (WSS) contributes to atherosclerosis from its inception, progression, and disruption of plaque. However, there is no previous study for an association between cerebral artery WSS and clinical outcome in…
- Trial name
- NCT05495191
- Testing
- Signal intensity gradient
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Chonbuk National University Hospital
Acute Ischemic Stroke
Blood Biomarkers to Predict the Prognosis of a Stroke Patient Undergoing Mechanical Thrombectomy
The goal of this observational study is to evaluate the accuracy of a panel of blood biomarkers and clinical variables in predicting the prognosis of stroke patients treated by mechanical thrombectomy, specifically to predict…
- Trial name
- TROMBOPOCT (NCT06467396)
- Testing
- Large Vessel Occlusion Biomarkers Test
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Ischemic Stroke, Myocardial Ischemia
Coronary Arteriosclerosis in Patients With Acute Ischemic Stroke
The specific objectives of this thesis are in a cohort of patients with an acute ischemic stroke, 1. To establish the degree of coronary arteriosclerosis. 2.
- Conditions
- Ischemic Stroke, Myocardial Ischemia, Coronary Arteriosclerosis
- Trial name
- CORAIS (NCT00701818)
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Vejle Hospital
Stroke
Study to Assess the Safety and Effectiveness of the Penumbra System
This clinical evaluation is a prospective, single-arm, multi-center trial. The purpose of this clinical evaluation is to assess the safety and effectiveness of the Penumbra System in the revascularization of patients presenting…
- Trial name
- NCT00334061
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penumbra Inc.