Clinical trials: Acute Kidney Injury, Renal Insufficiency
Renal Injury
The Effect of Neuromuscular Electrical Stimulation (NMES) on the Renal Function and Renal Blood Flow
A randomized prospective controlled study aims to evaluate the effect of neuromuscular electrical stimulation on the renal function and renal blood flow of post partum women with acute kidney injury.
- Trial name
- NMES (NCT04580329)
- Testing
- neuromuscular electrical stimulation (NMES) in addition to routine hospital care, routine hospital care without NMES
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed talaat ahmed aly
Acute Kidney Injury
Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery
This is a prospective randomized clinical trial designed to determine the effect of intraoperative dexmedetomidine administration on renal function after coronary artery bypass graft surgery.
- Trial name
- NCT06378827
- Testing
- Dexmedetomidine
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- University of Novi Sad
SARS-CoV Infection, Covid19
KIDney Injury in Times of COVID-19 (KIDCOV)
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable.
- Conditions
- SARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney Injury
- Trial name
- KIDCOV (NCT04705766)
- Testing
- Urine Collection
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contrast Induced Acute Kidney Injury
Study of APX-115 in Contrast Induced Acute Kidney Injury in Subjects Undergoing PCI
This phase 2 study is to assess the safety and efficacy of APX-115 active doses in Contrast Induced Acute Kidney Disease compared to placebo following multiple oral dosing in patients with undergoing percutaneous coronary…
- Trial name
- NCT05758896
- Testing
- Isuzinaxib (APX-115)
- Where
- 14 sites in United States, South Korea
- Volunteers
- 218 people
- Sponsor
- Aptabio Therapeutics, Inc.
Acute Kidney Injury
Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy
Critically ill patients with acute kidney injury (AKI) are at high risk of bleeding on account of coagulopathy, platelet dysfunction, frequent liver dysfunction and invasive procedures.In patients at high risk of bleeding…
- Trial name
- NCT01269112
- Testing
- citrate regional anticoagulation
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Geneva
Acute Kidney Injury
Biomarkers of Kidney Function in Transplant Medicine
Biomarkers of kidney function in transplant medicine is an international, multicentre, observational, non-interventional study. The project is aimed at monitoring biomarkers of acute kidney dysfunction in deceased organ donors…
- Trial name
- NCT05538234
- Testing
- Laboratory values - baseline, Medical information 12 hours before organ harvesting, Laboratory values - 12 hours after reperfusion
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Acute Kidney Injury, Renal Insufficiency
A Methodological Study to Learn More About Kidney Function in Healthy People and in People With Reduced Kidney Function
The main purpose of this study is to investigate how reliable a test assessing the renal functional reserve (RFR) and the maximum glomerular filtration rate (maxGFR) are.
- Trial name
- NCT07368712
- Testing
- No investigational study intervention
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Bayer
Acute Kidney Injury
An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury
This is a single center randomized trial that seeks to determine if the use of an automated real-time electronic medical record Acute Kidney Injury (AKI) risk score can improve patient outcomes through the use of an early…
- Trial name
- ESTOP-AKI (NCT03590028)
- Testing
- Early Nephrology Consult (ENC), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Chicago
Critical Illness, Acute Kidney Injury
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
- Trial name
- KETZEREI (NCT06021288)
- Testing
- Effluent dose of CRRT
- Where
- 2 sites in Germany
- Volunteers
- 165 people
- Sponsor
- Universität Münster
Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models.
- Trial name
- DEFEAT-AKI (NCT04633889)
- Testing
- Deferoxamine, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure Acute, Renal Dysfunction
Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75…
- Trial name
- K-PROSE (NCT07550790)
- Testing
- Furosemide, 0.9 % Normal Saline
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Jin Joo Park
Acute Kidney Injury, Hepatorenal Syndrome
Study of Accuracy of NGAL, a Renal Injury Biomarker, in Patients With Cirrhosis
The purpose of this study is to test the accuracy of urinary neutrophil-gelatinase associated lipocalin (NGAL) and other biomarkers (plasma renin, norepinephrine) to predict acute kidney injury (AKI) development in patients with…
- Trial name
- NCT02049125
- Where
- 4 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo
Critically Ill, Acute Kidney Injury
Magnesium Balance of Citrate-based Continuous Venovenous Hemofiltration, Effect of Citrate Dose.
Rationale: A higher citrate dose during continuous venovenous hemofiltration provides better anticoagulation but possibly a higher risk of citrate accumulation in case of metabolic limitations.
- Trial name
- NCT02194569
- Testing
- Citrate
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Ziekenhuis Oost-Limburg
Endothelial Dysfunction, Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs.
- Trial name
- NCT05344573
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Effect of CVVH on NGAL in Septic AKI
The plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with AKI is not affected by continuous venovenous hemofiltration (CVVH).
- Trial name
- NCT02536027
- Testing
- continuous venovenous hemofiltration
- Volunteers
- 30 people
- Sponsor
- First People's Hospital of Chenzhou
Acute Kidney Injury
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients…
- Trial name
- NEPHRO (NCT06150742)
- Testing
- Niyad (nafamostat mesylate)
- Where
- 10 sites in United States
- Volunteers
- 70 people
- Sponsor
- Talphera, Inc
The Recipients Undergoing Liver Transplantation
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT03344380
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Prostatectomy, Neutrophil Gelatinase-Associated Lipocalin
Evaluation of Kidney Damage Using NGAL Measurements
The main objective of this study is to evaluate whether blood NGAL measurement provides superiority over sCr and BUN tests in early diagnosis for assessing renal function in patients undergoing robotic urological surgery.
- Conditions
- Prostatectomy, Neutrophil Gelatinase-Associated Lipocalin, Kidney Function Tests
- Trial name
- NCT06274125
- Testing
- Robotic-Assisted Laparoscopic Radical Prostatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ankara City Hospital Bilkent
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.