Clinical trials: Acute Kidney Insufficiency
Acute Kidney Injury
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism
Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
- Trial name
- CAT-RISK (NCT07751874)
- Testing
- continuous renal replacement therapy with regional citrate anticoagulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Acute Kidney Injury
Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin
The goal of this clinical trial is to repurpose cilastatin for preventing acute kidney injury (AKI) in hospitalized patients receiving nephrotoxic medications. The trial will evaluate the efficacy of the re-purposed drug.
- Trial name
- PONTiAK (NCT06886464)
- Testing
- Cilastatin Sodium
- Where
- 2 sites in Canada
- Volunteers
- 698 people
- Sponsor
- Matthew James
the Patients With Partial Nephrectomy
Assessment of Acute Renal Injury During Partial Nephrectomy Using Neutrophil Gelatinase-associated Lipocalin (NGAL): Prospective Comparative Study Between Open, Video-assisted Minilaparotomy, Laparoscopic, and Robotic-assisted Laparoscopic Surgery
Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of acute kidney injury.
- Trial name
- NCT01891032
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Femur Fracture, Acute Renal Failure
Preventive Norepinephrine Infusion During Surgery for Upper Femoral Fracture and Post-operative Acute Renal Failure
The fracture of the upper extremity of the femur (FESF) is one of the most common fractures in traumatology. In France, FESF affects more than 65,000 individuals per year and could involve up to 150,000 people per year by 2050…
- Trial name
- NORAKI (NCT05566132)
- Where
- France
- Volunteers
- 676 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis, Acute Kidney Injury
A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis)
Biomarkers that provide an early indicator of kidney stress could be useful in clinical practice to detect silent episodes of acute kidney injury (AKI) or for early identification of subjects at risk of AKI.
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock
- Trial name
- LAPIS (NCT04434209)
- Testing
- Subject management guided by NephroCheck® test, Standard of Care
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 19 people
- Sponsor
- BioMérieux
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury After Open Heart Surgery, Venous Congestion After Open Heart Surgery
Evaluation of the Association Between the VEXUS Score and Hemodynamic Status and the Occurrence of Acute Kidney Injury After Open-Heart Surgery
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass and is associated with prolonged intensive care unit stay, increased morbidity, and mortality.
- Trial name
- NCT07805564
- Where
- Vietnam
- Volunteers
- 135 people
- Sponsor
- Hanoi Medical University
Acute Kidney Injury
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)
The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on…
- Trial name
- NCT01552525
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Acute Kidney Injury
Safety and Performance Evaluation of multiPlus Dialysate During CRRT
Assessment of the performance of multiPlus dialysate based on the serum creatinine removal 6 hours (360 min) after start of continuous veno-venous haemodialysis/ haemodiafiltration [CVVHD(F)].
- Trial name
- multiPlus (NCT05315817)
- Testing
- multiPlus dialysate
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Kidney Injury (AKI), Infusion of CD19 CAR T Cell
Occurrence of Acute Kidney Injury After CAR-T Cells Treatments in B-cell Lymphoma.
The investigators want to describe the incidence of AKI after CAR-T cells therapy in B-cell lymphoma. With the aim of highlight risk factors in AKI occurrence.
- Conditions
- Acute Kidney Injury (AKI), Infusion of CD19 CAR T Cell, B Cell Lymphoma
- Trial name
- AKI CAR (NCT07101913)
- Testing
- Incidence of acute kidney injury, Describe risk factors in AKI occurrence., Focus on patient with chronic kidney disease at baseline
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Aortic Dissection, Acute Kidney Injury
Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
The research aimed to predict postoperative acute kidney injury in patients with acute type A aortic dissection preliminarily by exploring the correlation of preoperative cystatin C level and incidence of postoperative acute…
- Trial name
- NCT05039814
- Testing
- postoperative acute kidney injury, none postoperative acute kidney injury
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Kidney Injury, Cardiac Surgery
Amino Acid Infusion in Cardiac Surgery
The goal of this study is to see if an infusion of amino acids given to adult male and female patients during cardiac surgery can help prevent acute kidney injury that commonly occurs when patients undergo cardiac surgery needing…
- Trial name
- NCT07030933
- Testing
- Travesol 10%
- Volunteers
- 130 people
- Sponsor
- Milton S. Hershey Medical Center
Pediatric Kidney Disease, Acute Kidney Injury
Registry for HF20 for Pediatric CRRT Under Emergency Use Authorization
Historically, innovations for acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) have centered around an adult population.
- Trial name
- NCT04836026
- Testing
- HF20™
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Kidney Injury, Inflammation
Light Therapy in Cardiopulmonary Bypass Surgery
The goal of this study is to determine whether or not exposure to blue spectrum light reduces acute kidney injury and systemic inflammation in subjects undergoing cardiopulmonary bypass.
- Trial name
- NCT02928887
- Testing
- Blue light
- Where
- United States
- Sponsor
- University of Pittsburgh
Kidney Failure, Acute, Shock
Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
This trial aims to study the effect of combining continuous and a new polyamide membrane with larger pores in the treatment of critically ill patients with acute renal failure and low blood pressure (shock) requiring…
- Trial name
- NCT00912184
- Testing
- Standard polyamide high flux membrane, High cut-off (super high flux) polyamide membrane
- Where
- Australia
- Volunteers
- 76 people
- Sponsor
- Austin Health
End-Stage Renal Disease, Renal Dialysis
EFFECTS OF HORTICULTURAL THERAPY ON ACUTE STRESS AND SALIVARY CORTISOL LEVELS IN HEMODIALYSIS PATIENTS
The purpose of this study is to evaluate the acute psychological and physiological effects of a single-session structured horticultural therapy program on patients undergoing routine hemodialysis.
- Conditions
- End-Stage Renal Disease, Renal Dialysis, Acute Stress
- Trial name
- NCT07845214
- Testing
- Horticultural Therapy
- Volunteers
- 80 people
- Sponsor
- Ataturk University
Abdomen, Acute, Myocardial Injury
MINS, AKI and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery
Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.
- Conditions
- Abdomen, Acute, Myocardial Injury, Acute Kidney Injury, Pulmonary Disease
- Trial name
- NCT04681508
- Testing
- Chest CT without contrast enhancement and chest X-ray
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Nordsjaellands Hospital
Kidney Failure
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side effects of Tacrolimus.
- Trial name
- NCT04258423
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Arthroplasty, Replacement, Knee, Acute Kidney Injury
After Surgery Acute Renal Failure Incidence in Total Knee Arthroplasty With and Without Tourniquet
This study analize the incidence of acute renal failure after performing total knee arthroplasty with or without use of tourniquet limb cuff (half of patients for each group) in a randomized clinical trial
- Conditions
- Arthroplasty, Replacement, Knee, Acute Kidney Injury, Tourniquets, Knee Osteoarthritis
- Trial name
- NCT03795805
- Testing
- total knee arthroplasty, Tourniquet limb cuff, Intaarticular lidocain
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Kidney Injury
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients…
- Trial name
- NEPHRO (NCT06150742)
- Testing
- Niyad (nafamostat mesylate)
- Where
- 10 sites in United States
- Volunteers
- 70 people
- Sponsor
- Talphera, Inc