Clinical trials: Acute Liver Injury
Drug-Induced Acute Liver Injury
The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI
The study adopted the design of multi-center, randomized, double-blind, positive control drug, superiority test, using the double-blind double-simulating skills.
- Trial name
- NCT05063500
- Testing
- bicyclol, 25mg/ tablet, polyene phosphatidylcholine capsules, 228mg/ particle.
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Drug Induced Liver Disease Study Group
Bleeding ,Arrhythmias, Heart Failure, Acute Renal Failure, Acute Liver Failure, Dyspnoea, Gout
Extended Drug Utilization Study Among Patients Exposed to Ticagrelor, Clopidogrel and Prasugrel
The purpose of the study is to describe patient characteristics and drug usage among patients that are prescribed ticagrelor for the first time and to compare them with patients who are prescribed clopidogrel and prasugrel for…
- Trial name
- NCT01276275
- Testing
- Risk of selected safety events
- Where
- Sweden
- Volunteers
- 7,200 people
- Sponsor
- AstraZeneca
Acute Kidney Injury
The Role of Biomarkers in the Early Detection of Acute Kidney Injury Induced by Liver Transplantation
Renal dysfunction is a major risk factor for poorer outcome after liver transplantation. Nevertheless, mechanisms of renal dysfunction in liver transplant recipients are not clearly understood.
- Trial name
- KILT (NCT01333319)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Drug-Induced Acute Liver Injury, Tuberculosis (TB)
Silymarin Versus N-Acetylcysteine as Protective Effect Against Anti-tuberculosis Drugs Induced Liver Injury.
Worldwide, tuberculosis (TB) infection caused by Mycobacterium Tuberculosis, remains one of the top 10 deadly diseases having a significant socioeconomic burden in the world, especially in developing countries.
- Trial name
- NCT07875322
- Testing
- Antituberculosis drugs Group
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Acute Liver Failure, Drug-Induced Liver Injury
Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure
Acute liver failure (ALF) is a serious condition in which the liver suddenly stops working, often leading to life-threatening complications.
- Trial name
- NCT06872372
- Testing
- N-Acetylcysteine (NAC) Treatment, Standard supportive care
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Lahore General Hospital
Acute Liver Failure, Acute Liver Injury
Biomarkers in Liver Failure
Acute liver injury (ALI) and acute liver failure (ALF) are rare clinical conditions, the latter often associated with a poor outcome.
- Conditions
- Acute Liver Failure, Acute Liver Injury, Acute on Chronic Hepatic Failure
- Trial name
- NCT02833064
- Testing
- Non-contrast magnetic resonance imaging, Biological sampling
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Hepatorenal Syndrome, Liver Cirrhosis
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
Patients with advanced cirrhosis of the liver develop kidney problems occasionally. This condition is called Hepatorenal Syndrome, requires hospitalization and frequently results in death.
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Trial name
- NCT06256432
- Testing
- Ambrisentan, Terlipressin
- Where
- 6 sites in India
- Volunteers
- 54 people
- Sponsor
- Noorik Biopharmaceuticals AG
Liver Transplantation and Antithrombin
Antithrombin III and Post-liver Transplantation Acute Kidney Injury
The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT).
- Trial name
- NCT04912193
- Testing
- Antithrombin III
- Where
- South Korea
- Volunteers
- 2,395 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Acute Lung Injury, Liver Transplantation
Risk Factors for Early Acute Lung Injury After Liver Transplantation in Children
The goal of this observational study is to identify the risk factors for early acute lung injury (ALI) after liver transplantation in children .The main questions it aims to answer are what the risk factors are for early ALI in…
- Conditions
- Acute Lung Injury, Liver Transplantation, Risk Factors
- Trial name
- NCT05752058
- Volunteers
- 300 people
- Sponsor
- Tianjin First Central Hospital
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Acute Liver Failure, Fulminant Hepatic Failure
A Multi-Center Trial to Study Acute Liver Failure in Adults
The purpose of this study is to collect clinical and epidemiological data as well as serum, plasma, urine, tissue and DNA samples on individuals who have acute liver failure and on individuals who have acute liver injury, a less…
- Conditions
- Acute Liver Failure, Fulminant Hepatic Failure, Acute Liver Injury
- Trial name
- ALFSG (NCT00518440)
- Where
- 12 sites in United States, Canada
- Volunteers
- 3,488 people
- Sponsor
- William Lee
Kidney Failure
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side effects of Tacrolimus.
- Trial name
- NCT04258423
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Drug-Induced Acute Liver Injury
Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose
Paracetamol (PCM) is a widely used over-the-counter analgesic, and overdose with PCM is a condition regularly seen in everyday clinical practice.
- Trial name
- NCT03679442
- Testing
- N-acetylcysteine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Drug-Induced Acute Liver Injury
The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI
The study adopted the superiority design of multi center, randomized, double-blind, positive control drug, dose finding, using two simulation skills.
- Trial name
- NCT02944552
- Testing
- bicyclol tablet 25mg, bicyclol tablet 50mg, polyene phosphatidylcholine capsule 456mg
- Where
- 17 sites in China
- Volunteers
- 244 people
- Sponsor
- Drug Induced Liver Disease Study Group
AKI - Acute Kidney Injury, CKD 5D, Hemodialysis
Personalized Two-stage Regional Citrate Anticoagulation for CRRT in Patients With Citrate Metabolism Impairment
The purpose of this study is to compare the efficacy and safety of an individualized two-stage calcium supplementation method versus a conventional commercial RCA-CRRT module in RCA-CRRT for patients with citrate metabolism…
- Conditions
- AKI - Acute Kidney Injury, CKD 5D, Hemodialysis, Hepatic Failure
- Trial name
- PRECISE (NCT07579663)
- Testing
- Two-stage calcium supplementation in RCA-CRRT, Commercial RCA-CRRT module
- Volunteers
- 142 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Renal Function, Liver Transplantation
Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Liver Transplantation
The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet.
- Trial name
- NCT02080065
- Testing
- living donor liver transplantation
- Where
- South Korea
- Volunteers
- 573 people
- Sponsor
- Samsung Medical Center
Cirrhosis, Liver, Acute Kidney Injury
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis.
- Conditions
- Cirrhosis, Liver, Acute Kidney Injury, Hepatorenal Syndrome
- Trial name
- RAKI-VAGA (NCT06525623)
- Testing
- Recommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital