Clinical trials: Acute Lung Injury(ALI)
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury (ALI)
Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy
The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.
- Trial name
- NCT01078831
- Testing
- Bronchoscopy
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Trauma
Synchronized Intermittent Mechanical Ventilation Versus Open Lung Ventilation With Spontaneous Respiration
The purpose of this study is to collect data on patients who are on breathing machines (ventilators) in the Trauma Surgical Intensive Care Unit (TSICU).
- Trial name
- SOLV (NCT00891085)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of New Mexico
Acute Lung Injury, Acute Respiratory Distress Syndrome
Noninvasive Positive Pressure Ventilation for ALI/ARDS:a Multicentre Randomized Controlled Trial
with appropriate inspired oxygen concentrations, NPPV would prevent intubation and hence avert the poor outcome associated with the need of invasive ventilation in patients with ALI/ARDS.
- Trial name
- NCT00343993
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury
The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission.
- Trial name
- LIPS (NCT00980915)
- Where
- United States
- Volunteers
- 6,600 people
- Sponsor
- Mayo Clinic
Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS)
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
The objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g.
- Conditions
- Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS), Sepsis
- Trial name
- NCT00854386
- Testing
- liberal fluid administration, restrictive fluid administration
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
ALI/ARDS Patients
Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Pressure Support Ventilation (PSV), Neurally Adjusted Ventilatory Assist (NAVA) and Controlled by Patient
The investigators' aim is to study the effect of pressure support ventilation versus neurally adjusted assist (NAVA) and controlled by patient in mechanically ventilated ALI/ARDS subjects.
- Trial name
- NCT00576771
- Testing
- PSV, NAVA, patient-controlled
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital
Acute Lung Injury
Treatment and Prevention of Acute Lung Injury (ALI) in Patients With COVID-19 Infection
The study aims to assess the potential benefit and evaluate the safety and tolerability of a single subcutaneous (SC) dose of VIB7734 in hospitalized patients with documented infection of severe acute respiratory syndrome…
- Trial name
- ALI (NCT04526912)
- Testing
- VIB7734
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Viela Bio
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Acute Lung Injury, Respiratory Distress Syndrome, Adult
Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients
With the perception that lung protective ventilation with regard to low tidal volume ventilation and limiting airway pressures improves outcome in ARDS (acute respiratory distress syndrome) and that the development of new…
- Trial name
- MEEP (NCT01992237)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Respiratory Distress Syndrome, Adult
Evaluating Health Outcomes and QOL After ALI Among Participants of the ALTA, OMEGA, EDEN, and SAILS ARDS Network Trials
Acute lung injury (ALI) is a severe lung condition that causes respiratory failure. The ARDS Network (ARDSNet) is a National Heart, Lung, and Blood Institute-sponsored network that is focused on improving treatments for people…
- Trial name
- ALTOS (NCT00719446)
- Where
- 6 sites in United States
- Volunteers
- 922 people
- Sponsor
- Johns Hopkins University
Acute Lung Injury
Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury
To assess the safety and efficacy of noninvasive positive pressure ventilation for patients with intro-pulmonary pulmonary acute lung injury and compare this with high-concentration oxygen therapy.
- Trial name
- NCT01581229
- Testing
- noninvasive positive pressure ventilation, oxygen therapy
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Beijing Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
This study will examine the hypothesis that iloprost maintains and improves ventilation perfusion matching in patients with pulmonary hypertension and ARDS/ALI as reflected by 1) an improved PaO2/FIO2 ratio as calculated from the…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Pulmonary Hypertension
- Trial name
- NCT01274481
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI)
A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation
Sepsis is a systemic inflammatory response syndrome triggered by infection, and it is a common critical illness in clinical practice, often leading to multiple organ dysfunction.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI), Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
- Trial name
- NCT07342205
- Testing
- Human-derived active intestinal bacterial liquid group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Acute Lung Injury, Mechanical Ventilation
NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury
Evaluation of a new ventilatory mode Neurally Adjusted Ventilatory Assist "NAVA" in patients who recover spontaneous breathing after acute lung injury.
- Trial name
- NCT00963066
- Testing
- PSV - pressure suppot ventilation, NAVA - Neurally Adjusted Ventilatory Assist, NAVA - EMG
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Acute Lung Injury
The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications
Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis…
- Trial name
- lung (NCT07477951)
- Testing
- Automated recruitment maneuver (Auto-RM)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Yongtao Sun
Sepsis, Acute Lung Injury
Statins for Acutely Injured Lungs From Sepsis
Objective: assess the efficacy and safety of oral rosuvastatin in patients with sepsis-induced Acute Lung Injury (ALI). Hypothesis: Rosuvastatin therapy will improve mortality in patients with sepsis-induced ALI.
- Trial name
- SAILS (NCT00979121)
- Testing
- Rosuvastatin
- Where
- 40 sites in United States
- Volunteers
- 745 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Primary Graft Dysfunction, Lung Transplantation
This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction
Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD).
- Conditions
- Primary Graft Dysfunction, Lung Transplantation, Acute Lung Injury(ALI), Natural Killer Cell Mediated Immunity
- Trial name
- MARAVIROC (NCT06853223)
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Failure, Acute Respiratory Distress Syndrome
Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography
Respiratory disorders are the leading cause of respiratory failure in children. Thousands of children are admitted to a pediatric intensive care unit each year and placed on mechanical ventilators.
- Conditions
- Respiratory Failure, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- EIT (NCT02247700)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston Children's Hospital
Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure
Comparing Closed-loop FiO2 Controller With Conventional Control of FiO2
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Conditions
- Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxemic and Hypercapnic Respiratory Failure
- Trial name
- NCT04568642
- Testing
- Activate FiO2 controller, Deactivate FiO2 controller
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital