Clinical trials: Acute Malnutrition
Moderate Acute Malnutrition
Choline to Prevent SAM in Children With MAM
The goal of this clinical trial is to test choline supplementation in children with moderate acute malnutrition in Malawi. The main question it aims to answer is: Will provision of RUSF with added choline (500mg/day) throughout…
- Trial name
- CHOP-MAM (NCT06214897)
- Testing
- C-RUSF (Ready-to-use Supplemental Food with added Choline), S-RUSF (Ready-to-use Supplemental Food without added Choline)
- Where
- 10 sites in Malawi
- Volunteers
- 1,515 people
- Sponsor
- Washington University School of Medicine
Malnutrition, Infection
Effectiveness of Supplementary Feeding During Infection Among Moderately Malnourished Children
The purpose of this study is to determine whether an outpatient-based strategy of short-term, ready to use supplementary food (RUSF) among moderately malnourished children with acute infections achieves greater improvement in…
- Trial name
- MODMAL (NCT00890695)
- Testing
- Ready to use supplementary food (RUSF)
- Where
- 2 sites in Kenya
- Volunteers
- 64 people
- Sponsor
- University of Oxford
Protein Malnutrition
Effect of Protein Supplementation After Bariatric Surgery
Obese patients, who underwent bariatric surgery, are at risk to develop protein malnutrition. The aim of this study is to evaluate the influence of postoperative protein supplementation on weight reduction, body composition and…
- Trial name
- EPEAB (NCT02001636)
- Testing
- Resource Instant Protein 88, Resource Maltodextrin
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University of Hohenheim
Hip Fracture, Vitamin D Deficiency
The Effect of Supplementation of Vitamin D Deficiency in Older People With Acute Hip Fracture:
This study will be done to evaluate the effect of load dose of vitamin D compared to the dose of usual clinical practice, in improving mobility and reducing disability in older people following a hip fracture.
- Trial name
- VITAMINA_D (NCT03213886)
- Testing
- Calcifediol (Vitamin D)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Leonor Cuadra Llopart
Severe Acute Malnutrition, HIV
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM
Malnutrition underlies 45% of child deaths, and has far-reaching educational, economic and health consequences. Severe acute malnutrition (SAM) affects 17 million children globally and is the most life-threatening form of…
- Conditions
- Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition
- Trial name
- Co-SAM (NCT05994742)
- Testing
- Rifampicin, Azithromycin, Isoniazid
- Where
- 9 sites in Kenya, Zambia and 1 more
- Volunteers
- 674 people
- Sponsor
- Queen Mary University of London
Pancreas Atrophy, Diabetes
Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas
Whilst there is an increasing prevalence of overweight and obesity worldwide, malnutrition remains common. In addition, malnutrition, overweight, and infections often interact.
- Conditions
- Pancreas Atrophy, Diabetes, Malnutrition
- Trial name
- SAMPA (NCT05361148)
- Testing
- no interventions will be used
- Where
- 4 sites in India, Philippines and 2 more
- Volunteers
- 2,305 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Diarrhea
Liberia National Community Health Assistant (NCHA) Program and Under-five Mortality
Last Mile Health (LMH) has partnered with the Liberian Ministry of Health (MOH) to support the design and implementation of the National Community Health Assistant Program (NCHAP).
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection, Malnutrition, Child
- Trial name
- NCT05123378
- Testing
- Liberia National Community Health Assistant Program
- Where
- Liberia
- Volunteers
- 23,702 people, healthy volunteers welcome
- Sponsor
- Last Mile Health
Acute Malnutrition, Severe, Malnutrition, Child
Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya
Child wasting is a type of malnutrition which occurs when a child becomes too thin. This medical condition increases the risk of becoming sick or dying.
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06441305)
- Testing
- SWITCH intervention package
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Continuous Renal Replacement Therapy, CO2 Removal
Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry
The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to…
- Conditions
- Continuous Renal Replacement Therapy, CO2 Removal, Nutrition Poor, Acute Renal Failure
- Trial name
- MECCIAS (NCT03314363)
- Testing
- blood gas analysis under citrate predilution, filter replacement, IC
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Severe Acute Malnutrition, Cognitive Impairment
Choline to Improve Malnutrition and Enhance Cognition
The goal of this clinical trial is to test adding choline to ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition (SAM) in Malawi.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Wasting, Kwashiorkor
- Trial name
- CHIME-SAM (NCT06154174)
- Testing
- C-RUTF (Ready-to-Use Therapeutic Food with added choline), S-RUTF (Ready-to-Use Therapeutic Food without added choline), Amoxicillin
- Where
- 10 sites in Malawi
- Volunteers
- 1,500 people
- Sponsor
- Washington University School of Medicine
Malnutrition Severe
PSYCHOSOCIAL STIMULATIONS AND TREATMENT OUTCOME OF SEVERE ACUTE MALNOURISHED CHILDREN
A playroom and a playground are already part of the stabilization unit and are furnished with basic facilities for engaging the SAM children in play-based motor, language, and personal-social activities.
- Trial name
- NCT06653790
- Testing
- Psychosocial stimulations
- Volunteers
- 800 people
- Sponsor
- Universiti Putra Malaysia
Vitamin D Deficiency, Respiratory Tract Infections
Vitamin D Supplementation for the Prevention of Acute Respiratory Infections: a RCT in Young Finnish Men
Vitamin D intervention effects on the prevention of acute respiratory tract infections among Young Finnish Men
- Trial name
- NCT05014048
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Tampere University
Severe Acute Malnutrition
Trial of High-Dose Vitamin D in the Treatment of Complicated Severe Acute Malnutrition
This double-blind randomized placebo-controlled controlled trial will test the hypothesis that administration of high-dose oral vitamin D supplementation to children in Lahore, Pakistan, who are recovering from complicated severe…
- Trial name
- ViDiSAM (NCT04270643)
- Testing
- Vitamin D3
- Where
- 2 sites in Pakistan
- Volunteers
- 259 people
- Sponsor
- Queen Mary University of London
Covid19, Vitamin D Deficiency
High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study
The world is currently facing a pandemic with the coronavirus (SARS-CoV-2) which leads to the disease of COVID-19. Risk factors for a poor outcome of COVID-19 have so far been identified as older age and co-morbidity including…
- Conditions
- Covid19, Vitamin D Deficiency, Corona Virus Infection, ARDS
- Trial name
- VitCov (NCT04525820)
- Testing
- Single high dose vitamin D, Treatment as usual vitamin D
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Severe Acute Malnutrition, Wasting
A Novel Low-Cost Tool for a More Efficient and Reliable Weight-for-Height/Length Assessment
Weight-for-height/length z-score is one of the indicators used to diagnose acute malnutrition. In the existing method, the assessment involves three steps and takes significant time with a wider room for errors.
- Trial name
- Yared's-tool (NCT03780348)
- Testing
- New Method, Existing Method
- Volunteers
- 510 people
- Sponsor
- JSI Research & Training Institute, Inc.
Severe Acute Malnutrition in Childhood, Malnutrition, Child
Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food
The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months.
- Conditions
- Severe Acute Malnutrition in Childhood, Malnutrition, Child, Neurocognition, Child
- Trial name
- NCT07345884
- Testing
- Lipid-Optimized Ready to Use Therapeutic Food (RUTF), Ready to Use Therapeutic Food (RUTF)
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- University of California, Los Angeles
Malnutrition
Study of Protein Metabolism in Healthy Older Subjects
This is a randomized, double-blinded, crossover study to evaluate muscle protein metabolism during fasting and feeding in healthy older subjects.
- Trial name
- NCT02052232
- Testing
- Experimental protein powder sachet, Control protein powder sachet
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acute Lung Injury
Intensive Nutrition in Acute Respiratory Distress Syndrome (ARDS): A Clinical Trial (INTACT)
The investigators propose a prospective randomized clinical trail to evaluate the impact of intensive medical nutrition therapy (IMNT) in patients with acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) on…
- Trial name
- INTACT (NCT01921101)
- Testing
- intensive medical nutrition, control
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Illinois at Chicago
Severe Acute Malnutrition, Cognitive Impairment
Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition
The goal of this clinical trial is to test the use of milk fat globule membrane (MFGM) in ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition in Sierra Leone.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Kwashiorkor, Severe Wasting
- Trial name
- MEND-SAM (NCT06869850)
- Testing
- MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food), S-RUTF (standard ready-to-use therapeutic food), Amoxicillin
- Where
- 10 sites in Sierra Leone
- Volunteers
- 1,600 people
- Sponsor
- Washington University School of Medicine