Clinical trials: Acute Moderate-to-severe Pain
Dehydration, Gastroenteritis
Intravenous (IV) Solutions for Dehydration in Children With Gastroenteritis
The primary objective of this study is to compare the efficacy and safety of the use of a multiple electrolyte solution to the use of saline for the treatment of moderate to severe dehydration due to acute gastroenteritis (AGE)…
- Trial name
- NCT01234883
- Testing
- multiple electrolyte solution, saline
- Where
- 9 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Baxter Healthcare Corporation
COVID-19
A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19
The purpose of this clinical trial is to learn about how study medicine (Paxlovid, which contains nirmatrelvir and ritonavir) is changed and eliminated from the body, as well as its safety, and the extent to which side effects…
- Trial name
- NCT05386472
- Testing
- nirmatrelvir, ritonavir
- Where
- 13 sites in United States
- Volunteers
- 25 people
- Sponsor
- Pfizer
Acute Pain
A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients
The purpose of this study is to demonstrate the efficacy and safety of Intravenous (IV) acetaminophen plus rescue opioids for the relief of moderate to severe acute pain in neonates and infants (age < 2 years) compared to placebo…
- Trial name
- NCT01635101
- Testing
- IV Acetaminophen, IV Control
- Where
- 22 sites in United States
- Volunteers
- 197 people
- Sponsor
- Mallinckrodt
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Pain, Postoperative, Orthopedic Procedures
A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain
The purpose of this small study was to investigate the safety and effectiveness of OROS hydromorphone HCI for the treatment of short-term, moderate to severe postoperative pain following total knee replacement surgery.
- Conditions
- Pain, Postoperative, Orthopedic Procedures, Analgesia
- Trial name
- NCT00411307
- Testing
- OROS hydromorphone HCI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alza Corporation, DE, USA
SARS-CoV Infection
Efficacy and Safety of Ozonised Oil (HOO) in COVID-19 Patients
The anti-viral efficacy of ozone against RNA viruses is already established. Ozone gas have been already proposed as possible therapy for Covid-19 infection with insofar limited success.
- Trial name
- HOO-COVID (NCT04651387)
- Testing
- Ozonized oil (HOO
- Sponsor
- Neuromed IRCCS
Acute Respiratory Distress Syndrome, Infections
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS…
- Trial name
- NCT05947955
- Testing
- Rhu-pGSN, normal saline
- Where
- 65 sites in United States, Belgium and 11 more
- Volunteers
- 600 people
- Sponsor
- BioAegis Therapeutics Inc.
Anemia Acute, Fatigue
ABC - A Post Intensive Care Anaemia Management Trial
On discharge from intensive care (ICU) patients are often severely anaemic (have a low level of haemoglobin (Hb) in their red blood cells (RBC)). Anaemia can persist for many months making patients feel tired and fatigued.
- Conditions
- Anemia Acute, Fatigue, Physical Disability, Quality of Life
- Trial name
- NCT04591574
- Testing
- Red Blood Cells (Transfusion)
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- University of Edinburgh
Acute Moderate to Severe Pain
Extension Study to Evaluate the Safety of Q8003 in Patients With Acute Moderate to Severe Pain
This is a Phase 3 double-blind, multiple dose safety extension study of Q8003 administered at daily doses up to 36 mg morphine/24 mg oxycodone (Q8003 36mg/24mg) over a treatment period of up to 4 weeks.
- Trial name
- NCT00565760
- Testing
- Q8003
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- QRxPharma Inc.
Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation for Moderate-to-severe Acute Respiratory Distress Syndrome
This study will examine the feasibility of a large clinical trial investigating the effectiveness of airway pressure release ventilation and low tidal volume ventilation for patients with moderate-to-severe acute respiratory…
- Trial name
- EARL (NCT04156438)
- Testing
- Low tidal volume ventilation, Airway pressure release ventilation
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Bronchiectasis Adult
Airway Clearance and Bronchoalveolar Lavage for Bronchiectasis Patients With Exacerbation
No study have evaluated the efficacy and safety of airway clearance therapy (ACT) and bronchoalveolar lavage (BAL) under bronchoscope for bronchiectasis.
- Trial name
- NCT03643302
- Testing
- Version BF-1T26 electronic bronchoscope
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Optic Neuritis
Efgartigimod for the Treatment of Acute Optic Neuritis
The goal of this pilot clinical trial is to test efgartigimod alfa against placebo in adults with first-time optic neuritis (optic nerve inflammation).
- Trial name
- PET-AON (NCT06453694)
- Testing
- Efgartigimod Alfa
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Anastasia Vishnevetsky, MD, MPH
Moderate Acute Respiratory Distress Syndrome
Strategy of UltraProtective Lung Ventilation With Extracorporeal CO2 Removal for New-Onset Moderate to seVere ARDS
Pathophysiological, experimental and clinical data suggest that an '"ultraprotective" mechanical ventilation strategy may further reduce VILI and ARDS-associated morbidity and mortality.
- Trial name
- SUPERNOVA (NCT02282657)
- Testing
- ECCO2R will be initiated during the 2-hour run-in time, Neuromuscular blocking agents (NMBA), Ventilation
- Where
- Belgium
- Volunteers
- 95 people
- Sponsor
- European Society of Intensive Care Medicine
Acute Migraine
Chordate System S020 Acute Migraine Clinical Investigation
The main purpose of the study is to evaluate the impact of treatment with the Chordate System S020 (medical device) on acute migraine headache pain.
- Trial name
- Amici (NCT02185703)
- Testing
- Chordate System S020 in treatment mode
- Where
- 9 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Chordate Medical
Pneumonia, Bacterial
Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae
A COMPARASON OF CIDECIN™ (DAPTOMYCIN) TO ROCEPHIN® (CEFTRIAXONE) IN THE TREATMENT OF MODERATE TO SEVERE COMMUNITY-ACQUIRED ACUTE BACTERIAL PNEUMONIA DUE TO S. PNEUMONIAE
- Trial name
- NCT00540072
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Postoperative Pain, Acute
PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)
The goal of this clinical trial is to evaluate the analgesic activity of PF614 (an oral oxycodone prodrug extended-release analgesic) for control of postsurgical pain in subjects scheduled for abdominoplasty surgery.
- Trial name
- NCT06602271
- Testing
- PF614 capsule
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Ensysce Biosciences
Acute Respiratory Distress Syndrome, Covid19
Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19
Acute myocardial injury has been a finding of variable frequency among patients diagnosed with COVID-19. It is now recognized that cTnI levels are strongly associated with increased mortality.
- Conditions
- Acute Respiratory Distress Syndrome, Covid19, Myocardial Injury
- Trial name
- PREMIER (NCT04760821)
- Testing
- Trimetazidine
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Ministry of Health, Brazil
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Pulmonary Arterial Hypertension
Acute Dosing of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-003)
This clinical trial will study the safety, tolerability, and pharmacodynamics of single doses of MK-8892 in participants with pulmonary arterial hypertension (PAH).
- Trial name
- NCT01934647
- Testing
- MK-8892
- Volunteers
- 7 people
- Sponsor
- Merck Sharp & Dohme LLC
Participants With Acute Moderate to Severe Pain Following Abdominal Surgery
Efficacy and Safety of Intravenous Meloxicam in Subjects With Moderate-to-severe Pain Following Abdominal Surgery
This study aims to evaluate the analgesic efficacy and safety of meloxicam injection in subjects with moderate-to-severe pain following abdominal surgery.
- Trial name
- NCT06904248
- Testing
- Meloxicam Injection, Sodium Chloride Injection
- Where
- 18 sites in China
- Volunteers
- 224 people
- Sponsor
- Yangtze River Pharmaceutical Group Co., Ltd.