Clinical trials: Acute Myeloid Leucemia, open to volunteers
Acute Myeloid Leukemia
This Study Aims to Improve the Stratification of Patients With Acute Myeloid Leukemia to Enable More Personalized and Effective Treatments, and to Identify and Functionally Validate, at the Single-cell Level, Biomarkers That Can Predict Response to Venetoclax.
The current classification of acute myeloid leukemias (AML) includes more than 20 different diseases, grouped based on their distinctive genomic characteristics, which reflect substantial heterogeneity.
- Trial name
- AMANITA (NCT07874100)
- Testing
- Bulk genotyping of AML samples at diagnosis and relapse, scRNA analysis at diagnosis, scRNAseq and genotyping analysis at day 28 after therapy, spatial transcriptomic analysis at day 0 and 28
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Venentoclax, Myeloid Malignancies
Fludarabine Plus Melphalan Versus Addition of Venetoclax to Fludarabine/Melphalan Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in AML/MDS Patients Aged > 50 Years: a Multicenter, Randomized, Phase 3 Trial
Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) serves as a curative treatment modality for the vast majority of patients with hematological malignancies.
- Conditions
- Venentoclax, Myeloid Malignancies, Conditioning, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- NCT07396480
- Testing
- Venetoclax in combination with fludarabine and melphalan, Fludarabine and Melphalan
- Where
- 18 sites in China
- Volunteers
- 186 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Myeloid Leucemia, High-risk Myelodysplastic Syndrome (MDS)
Creation of a Biocollection of Patients With Acute Myeloid Leukemia (AML) or Lymphoid Leukemia (ALL) or High-risk Myelodysplastic Syndrome (MDS) Monitored at the Nantes University Hospital
The aim of the LANA bio-collection is to collect samples from patients with Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL) or or high-risk myelodysplastic syndrome (MDS) to facilitate access to the leukemic or…
- Conditions
- Acute Myeloid Leucemia, High-risk Myelodysplastic Syndrome (MDS), Acute Lymphoid Leukemia
- Trial name
- LANA (NCT06681363)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Acute Myeloid Leucemia
Single Cell Acute Leukemia Analysis
Numerous chemotherapy and immunotherapy resistance genes have been identified in cancers in general and acute myeloid leukemia in particular.
- Trial name
- SCALA (NCT06906978)
- Testing
- blood sampling
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille