Clinical trials: Acute Myocardial Infarction, completed
Acute Myocardial Infarction
Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction
The purpose of this study is to determine the efficacy of intravenous human beta natriuretic peptide (BNP, Nesiritide) as compared to placebo to prevent adverse post acute myocardial infarction left ventricular remodeling.
- Trial name
- Believe II (NCT00573144)
- Testing
- Nesiritide
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Mayo Clinic
Myocardial Infarction
Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism
Percutaneous coronary intervention (PCI) with stent implantation is the preferred reperfusion strategy for treatment of acute myocardial infarction (AMI).
- Trial name
- ACCELAMI2C19 (NCT00915733)
- Testing
- cilostazol, clopidogrel (Plavix), CYP2C19
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Gyeongsang National University Hospital
Myocardial Infarction
Bone Marrow-Derived Stem Cell Transfer in Acute Myocardial Infarctions
The benefit of reperfusion therapies for ST-elevation acute myocardial infarction (STEMI) is limited by postinfarction left ventricular (LV) dysfunction.The purpose of this study is to determine whether intracoronary transfer of…
- Trial name
- NCT00264316
- Testing
- bone marrow-derived stem cell transfer
- Where
- Belgium
- Volunteers
- 68 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
STEMI - ST Elevation Myocardial Infarction
A Randomized Comparison of Long-Term Healing Between Biodegradable- Versus Durable-Polymer Everolimus Eluting Stents in STEMI
This study aims to compare the acute thrombogenecity and frequency of neoatherosclerotic lesions and other aspects of long term arterial healing such as the frequency of malapposed and uncovered stent struts at 3 years among…
- Trial name
- CONNECT (NCT03440801)
- Testing
- Synergy, Xience
- Where
- Japan
- Volunteers
- 240 people
- Sponsor
- Tokorozawa Heart Center
Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l)
Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)
The proposed study is a sub-study of the CANTOS trial (A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable…
- Conditions
- Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l), Reduced Left Ventricle Ejection Fraction (<50%), Symptoms of Heart Failure (NYHA Class II-III)
- Trial name
- NCT01900600
- Testing
- Cardiopulmonary exercise test, Echocardiogram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Acute Coronary Syndrome
Imaging Whole Coronary Artery With Intravascular Ultrasound (Ivus) And Imap For Plaque Tissue Composition In Patients With Acute Myocardial Infarction
The iWONDER trial has the following objective: To analyze the morphological, phenotypic and tissue characteristics of atherosclerotic plaques angiographically considered "culprit" and "not-culprit" in patients undergoing coronary…
- Trial name
- iWONDER (NCT01437553)
- Testing
- iMAP
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Acute Myocardial Infarction (AMI)
Predictors and Impact of Total Occlusion of the Infarct-Related Coronary Artery on Short-Term Outcomes
Aim of this study is to determine the prevalence, predictors, and impact of total occlusion of the infarct-related coronary artery (IRA) on short-term mortality.
- Trial name
- NCT07086807
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Sestre Milosrdnice
STEMI
The Microcirculation in Acute Myocardial Infarction (Micro-AMI)
This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.
- Trial name
- Micro-AMI (NCT01552564)
- Testing
- Index of microvascular resistance, Cardiac magnetic resonance, Blood markers
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Bristol
Acute Myocardial Infarction
FINGER; Finland-Germany Myocardial Infarction Study
The purpose of this observational study is to find characteristics and risk stratification methods for identification of subjects who have increased risk of death, especially sudden cardiac death, after acute myocardial…
- Trial name
- FINGER (NCT00828698)
- Testing
- No intervention
- Where
- 2 sites in Finland, Germany
- Sponsor
- University of Oulu
Coronary Disease, Cardiovascular Disease
Gender Differences in the Development, Treatment and Prognosis of Coronary Disease: A CALIBER Study
The initial manifestation of symptomatic coronary disease can range from angina (or symptoms of angina), unheralded acute coronary syndrome (ACS), or unheralded coronary death.
- Trial name
- NCT01164371
- Volunteers
- 1,758,584 people
- Sponsor
- University College, London
Acute Coronary Syndrome
Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy
Primary Objective: To demonstrate the superior efficacy (composite of all-cause death + Myocardial Infarction (MI)) of Otamixaban to Unfractionated Heparin (UFH) + Eptifibatide Secondary Objectives: To demonstrate the superior…
- Trial name
- TAO (NCT01076764)
- Testing
- Otamixaban, UFH, Eptifibatide
- Where
- 607 sites in United States, Argentina and 53 more
- Volunteers
- 13,220 people
- Sponsor
- Sanofi
Acute Myocardial Infarction
Safety and Efficacy of Three Different Loading Doses of Clopidogrel, in Patients With Acute Myocardial Infarction
The aim of this study is to determine both safety and effectiveness of three different loading dose regimens of clopidogrel in patients with acute myocardial infarction undergoing primary angioplasty.
- Trial name
- Load & Go (NCT00882739)
- Testing
- Clopidogrel 300 mg, Clopidogrel 600 mg, Clopidogrel 900 mg
- Where
- Italy
- Volunteers
- 168 people
- Sponsor
- Ospedale San Donato
Myocardial Infarction, Thrombus
RETRIEVE-AMI Study
Heart attacks are caused by the sudden formation of a clot inside a diseased coronary artery which reduces blood flow beyond the blockage site.
- Conditions
- Myocardial Infarction, Thrombus, Coronary Artery Disease
- Trial name
- RETRIEVE-AMI (NCT05307965)
- Testing
- Retriever Thrombectomy, Percutaneous Coronary Intervention, Thrombus Aspiration
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- Oxford University Hospitals NHS Trust
Myocardial Infarction
Firibastat or Ramipril After Acute Myocardial Infarction for Prevention of Left Ventricular Dysfunction
This is a multicenter, randomized, double-blind, active-controlled, dose-titrating phase 2 study to evaluate the safety and efficacy of firibastat administered orally BID (2 daily doses) versus ramipril administered orally BID…
- Trial name
- QUORUM (NCT03715998)
- Testing
- Ramipril, Firibastat
- Where
- 7 sites in France, Germany and 5 more
- Volunteers
- 295 people
- Sponsor
- Quantum Genomics SA
Left Ventricular Remodeling, Acute Myocardial Infarction
Danlou Tablets to Prevent Left Ventricular Remodeling
Danlou tablets are Chinese patent medicine which has been approved in China for the treatment of ischemic heart disease, but the evidence supporting its efficacy on cardiac remodeling remains unclear.
- Trial name
- NCT02675322
- Testing
- Danlou Tablets
- Volunteers
- 82 people
- Sponsor
- shuai Mao
Cardiovascular Disorder
Study To Assess The Efficacy Of A Cholesterol Lowering Drug On Top Of Statins In Patients After Myocardial Infarction (MI)(0653A-150)
Collecting local data, safety and experience trial.
- Trial name
- NCT00652717
- Testing
- Ezetimibe, simvastatin
- Volunteers
- 280 people
- Sponsor
- Organon and Co
Acute Myocardial Infarction
Application of Index of Microcirculatory Resistance to Evaluate Myocardial Protection After Ischemic Adaptation
To evaluate the protective effect of IPC on the myocardial microcirculation response through IMR and the predictive value of IMR on the degree of myocardial reperfusion and the prognosis of patients.
- Trial name
- NCT04952740
- Testing
- IPC+PCI, No IPC
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Myocardial Infarction
Efficacy of Early Administration of Clotinab in Acute Myocardial Infarction
The ADMIRAL (Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction) study demonstrated that early administration of abciximab in patients with ST elevation acute myocardial infarction…
- Trial name
- ECLAT-STEMI (NCT00841438)
- Testing
- Clotinab
- Where
- 31 sites in South Korea
- Volunteers
- 786 people
- Sponsor
- Yonsei University
Acute Coronary Disease, Angina Unstable
Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS
The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death (CV death), myocardial infarction (MI), stroke) after a…
- Trial name
- CURRENT/OASIS7 (NCT00335452)
- Testing
- Clopidogrel, acetylsalicyclic acid (ASA)
- Where
- 38 sites in United States, Argentina and 36 more
- Volunteers
- 25,086 people
- Sponsor
- Sanofi
Coronary Heart Disease
System Delay and Clinical Outcome Among Chinese Patients With AMI Treated With Reperfusion Therapy (MOODY Study)
Acute myocardial infarction (AMI) pose a pool clinical outcome to men and women whom treatment was delayed. However, reperfusion time was limited in previous studies.
- Trial name
- MOODY (NCT03051048)
- Testing
- Reperfusion
- Where
- 23 sites in China
- Volunteers
- 8,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University