Clinical trials: Acute Myocarditis
Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis
Medicine-induced Cardiac Hemodialysis on COVID-19
The clinical trial studies the human pathogen of SARS-CoV-2, with a specificity in the circulating Spike 2 protein in the human system.
- Conditions
- Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis, Vaccines, Myocarditis Allergic
- Trial name
- NCT05711810
- Testing
- Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yang I. Pachankis
COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
Long COVID or Postacute sequelae of COVID-19 infection (PASC) are increasingly recognised complications, defined by lingering symptoms, not present prior to the infection, typically persisting for more than 4 weeks.
- Conditions
- COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle, Remodeling, Vascular, Left Ventricular Dysfunction
- Trial name
- MYOFLAME-19 (NCT05619653)
- Testing
- Prednisolone, Losartan
- Where
- 5 sites in Austria, Germany
- Volunteers
- 279 people
- Sponsor
- Valentina Puentmann
Myocarditis Acute, Myocardial Inflammation
CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance
Patients with acute myocarditis (AM) usually experience spontaneous healing, but a considerable percentage of them evolve towards chronic long-term cardiac impairment.
- Trial name
- MIAMI (NCT03525639)
- Testing
- Cardiac Magnetic Resonance
- Where
- 3 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Antonio Esposito
Myocarditis; Acute or Subacute, Takotsubo Cardiomyopathy
Characterization of Acute Myocardial Damage With Spectral Computed Tomography. (CADAMI-SPECTRAL)
Clinical management of patients with chest pain and elevation of biomarkers of myocardial injury require an accurate diagnosis. Until now, cardiac magnetic resonance imaging (cMRI) is the gold standard for the diagnosis among…
- Conditions
- Myocarditis; Acute or Subacute, Takotsubo Cardiomyopathy, Infarction, Myocardial, Myocardial Injury
- Trial name
- CADAMI (NCT06506071)
- Testing
- Spectral CT
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Salamanca University Hospital
Myocarditis, Myocarditis Acute
Outcome of Clinical Phenotypes of Pediatric Myocarditis at Assiut University Children Hospital
This study aims to investigate the clinical phenotypes, management approaches, and outcomes of myocarditis in children admitted to Assiut University Children's Hospital.
- Trial name
- PED-MYO (NCT07175948)
- Testing
- Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Myocarditis
Clinical, Morphological and Functional Aspects in Myocarditis.
Cardiac magnetic resonance (CMR) is accurate to identify acute myocardial damage (edema, hyperemia, and/or fibrosis) due to acute myocarditis (AM).
- Trial name
- NCT04217876
- Testing
- post-processing analysis of cardiac imaging (strain echocardiography)
- Where
- 4 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Messina
ACS (Acute Coronary Syndrome), Myocardial Infarction (MI)
TIRANA-ACS: A Prospective Registry Study for the Targeted Investigation of Residual Inflammation After Non-ST/ ST Elevation Acute Coronary Syndrome
This prospective observational study aims to evaluate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) as a predictor of mortality in patients following an episode of Acute Coronary Syndrome (ACS).
- Conditions
- ACS (Acute Coronary Syndrome), Myocardial Infarction (MI), Myocardial Inflammation, Inflammation Biomarkers
- Trial name
- TIRANA (ACS) (NCT07026708)
- Where
- Albania
- Volunteers
- 1,600 people
- Sponsor
- University Hospital Centre Mother Teresa
Acute Myocarditis
Corticoid Therapy in Acute Myocarditis
Refer to the "Detailed Description" section.
- Trial name
- COTAM (NCT06522100)
- Testing
- Intravenous administration of Methylprednisolone, Oral Prednisone
- Volunteers
- 420 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myocarditis
64Cu-GRIP B in Patients With Acute Myocarditis
The proposed patient study represents the first-ever acute myocarditis patient imaging study with 64Cu-GRIP B PET. The tracer is designed to detect extracellular granzyme B as it is secreted by activated cytotoxic T lymphocytes…
- Trial name
- NCT07481136
- Testing
- 64Cu-GRIP B is a radiolabeled peptide tracer, a copper-64 isotope bound to a peptide designed to target extracellular Granzyme B
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Javid Moslehi, MD
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Coronary Artery Disease, Arrhythmias, Cardiac
Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics
The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear.
- Conditions
- Coronary Artery Disease, Arrhythmias, Cardiac, Heart Valve Diseases, Aortic Dissection
- Trial name
- PROSPECT (NCT06001073)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Myocarditis Acute
Non-Steroidal Anti-Inflammatory Drugs in Acute Myocarditis
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of a 3-week ibuprofen tapering regimen compared to conventional analgesic treatment (acetaminophen) in patients with acute…
- Trial name
- INFLAMA (NCT06686862)
- Testing
- ibuprofen
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Myocarditis Acute, Inflammatory Cardiomyopathy
Creation of a National Multicenter Platform for the Study of Inflammatory Myocardial Disease: Pre-MYO Cohort
The objectives of this project are: 1) to comprehensively characterize a large national cohort of patients with suspected myocarditis, their clinical phenotype, care management, blood and imaging biomarkers, epidemiological…
- Trial name
- PREMYO (NCT06898762)
- Testing
- characterization of a large national cohort of patients with suspected myocarditis or inflammatory cardiomyopathy.
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Myocarditis Acute, Ventricular Arrhythmia
Arrhythmic Risk in Myocarditis Outcome Research
The goal of this observational, retrospective, multicenter study is to characterize the arrhythmic burden and identify predictive factors for ventricular arrhythmias (VAs) in adult patients hospitalized for acute myocarditis…
- Trial name
- ARMOR (NCT07501481)
- Testing
- Treatment of acute myocarditis
- Volunteers
- 1,500 people
- Sponsor
- AZ Sint-Jan AV
Acute Cellular Graft Rejection, Cardiac Sarcoidosis
[68Ga]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
Acute myocardial inflammation is an heterogenic syndrome involving different clinical pathologies with different outcome. For the purpose of this study protocol, we focuse on three entities of this syndrome, namely the acute…
- Conditions
- Acute Cellular Graft Rejection, Cardiac Sarcoidosis, Myocarditis Due to Drug
- Trial name
- NCT05499637
- Testing
- [68Ga]Ga-PentixaFor PET/CT
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- John O. Prior
Myocardial Infarction, Myocardial Injury
Lymphatic Organs and Myocardium After Myocardial Infarction
The adaptive immune response plays an important role in myocardial healing and remodeling after acute myocardial infarction in patients. Therefore, the involved lymphocytes represent a novel target for therapeutic interventions.
- Conditions
- Myocardial Infarction, Myocardial Injury, Myocardial Inflammation
- Trial name
- LOMI (NCT05519735)
- Testing
- Multimodality Imaging
- Where
- 2 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Wuerzburg University Hospital
Myocarditis
The Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: a 2-centre Study
The purpose of the present study was to investigate ECG findings of patients with acute myocarditis, ECG findings associated with fulminant myocarditis, and the characteristics of ST-elevation on admission.
- Trial name
- NCT04498494
- Testing
- ECG
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Yuanli Lei
Myocarditis, Myocarditis Acute
MYocarditis and/or Pericarditis Following mRNA COVID-19 VACCination National Surveillance Study
Myocarditis is inflammation of the heart muscle. Pericarditis is inflammation of the lining surrounding the heart muscle. Symptoms of these conditions can include pain in the chest and rapid or irregular heartbeat.
- Conditions
- Myocarditis, Myocarditis Acute, Pericarditis, Pericarditis Acute
- Trial name
- MYCOVACC (NCT06103123)
- Testing
- Stand of care ECG, Holter, MRI, ECHO, Quality of life questionnaire, Baseline Quality of Life questionnaire
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Cardiology Research UBC
Myocarditis
Value of Heart Rate Lowering Therapy in Acute Myocarditis
To study the value of heart rate lowering therapy "pharmacological rest" on the short term in cases of myocarditis without LV dysfunction.
- Trial name
- NCT06312891
- Testing
- Ivabradine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Myocarditis Acute, Ventricular Arrythmia
Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis
Myocarditis is an inflammatory disease of the heart muscle which is mostly caused by viruses, bacteria, parasites, toxic substances/drugs or by primary autoimmune mechanisms.
- Trial name
- AIM-ICD (NCT04264455)
- Testing
- Biomonitor, Life Vest, Implantable Cardioverter-Defibrillator (ICD)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Wuerzburg University Hospital