Clinical trials: Acute Neurological Injury
SARS-CoV Infection, Covid-19
Characterizing the Immune Response and Neuronal Damage in COVID-19
The Investigators plan to study the innate and adaptive immune response, the inflammatory response, and associated complications such as complement activation and neurological damage in SARS-Cov-2 infected individuals.
- Trial name
- NCT04510012
- Testing
- Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Field Physician Care, Analgesics
Analgesia in ÖAMTC Helicopter Emergency Service in Austria
A sufficient analgesia in injured or sick people is the main goal of physicians treating a patient. In emergency medicine potent analgesia like ketamine or opioids are routinely used.
- Conditions
- Field Physician Care, Analgesics, Hypnotics, Emergencies
- Trial name
- NCT03760302
- Testing
- analgesics, hypnotics
- Where
- Austria
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Pain, Acute
Efficacy and Safety of Penthrox® Combined With a Standard Analgesia (SoC) in Adult Patients Admitted to the Emergency Department With Moderate to Severe Pain Associated With Trauma
A phase 4 randomised, double-blind study to assess the efficacy and safety of Penthrox® used from the outset in multimodal analgesia, in combination with the standard analgesic protocol used in the department, for conscious adult…
- Trial name
- Pen ASAP (NCT03798899)
- Testing
- Methoxyflurane, Normal Saline
- Where
- 8 sites in France
- Volunteers
- 360 people
- Sponsor
- Mundipharma SAS
Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity
Initial Volume Status in Patients With Acute Brain Injury is Associated With Neurological Prognosis
In this study, we investigated the clinical variability in paroxysmal sympathetic hyperactivity in patients with acute brain injury and examined the prognostic value of the Paroxysmal Sympathetic Hyperactivity Assessment Measure…
- Conditions
- Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity, Volume Status, Right Heart Function
- Trial name
- NCT06090812
- Testing
- Ultrasound evaluation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Cardiac Arrest, Stroke
Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment
PANGEA is an international prospective point prevalence study to describe the epidemiology, interventions, and outcomes in children with acute critical brain disease.
- Conditions
- Cardiac Arrest, Stroke, Traumatic Brain Injury, Brain Mass
- Trial name
- PANGEA (NCT02381977)
- Testing
- No intervention
- Volunteers
- 922 people
- Sponsor
- University of Pittsburgh
Stroke, Incomplete Spinal Cord Injury
Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
The purpose of the project is to compare intensity (minutes in target heart rate zone) and steps per session across three gait training modalities, including body-weight supported treadmill training (BWSTT), overground gait…
- Trial name
- NCT06169657
- Testing
- Body-weight-supported treadmill training (BWSTT), EksoNR exoskeleton gait training, Overground gait training
- Where
- United States
- Sponsor
- Shirley Ryan AbilityLab
Acute Pain
A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients
The purpose of this study is to demonstrate the efficacy and safety of Intravenous (IV) acetaminophen plus rescue opioids for the relief of moderate to severe acute pain in neonates and infants (age < 2 years) compared to placebo…
- Trial name
- NCT01635101
- Testing
- IV Acetaminophen, IV Control
- Where
- 22 sites in United States
- Volunteers
- 197 people
- Sponsor
- Mallinckrodt
Ototoxicity
SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity
The primary objective of this study is to determine the safety and efficacy of SPI-1005 treatment in CF patients with active pulmonary exacerbation that are receiving an IV course of tobramycin, determined by comparing hearing…
- Trial name
- NCT02819856
- Testing
- SPI-1005 Ebselen 200mg Capsule x1, SPI-1005 Ebselen 200mg Capsule x2, SPI-1005 Ebselen 200mg Capsule x3
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Hip Fractures, Pain, Acute
The Impact of Integrated Preoperative Fascia Iliaca Compartment Block in Elderly Hip Fracture
This prospective randomized controlled study is aimed to determine the advantages of post-admission fascia iliaca compartment block (FICB) in geriatric hip fracture surgery combination with multimodal analgesia compared with no…
- Conditions
- Hip Fractures, Pain, Acute, Hip Fracture Surgery, Delirium in Old Age
- Trial name
- NCT05857462
- Testing
- Post-admission FICB
- Where
- Thailand
- Volunteers
- 420 people
- Sponsor
- Mahidol University
Fractures
Virtual Reality in Reducing Acute Orthopedic Pain
The primary aim of this research is to show that a virtual reality (VR) service line is feasible and can sustain itself with the ability to take care of patients.
- Trial name
- NCT06624969
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Bowel Obstruction
Emergency General Surgery for Non-trauma
This study will observe the postoperative morbidity and mortality trends in patients with non- traumatic abdominal pathology who will undergo emergency general surgery.
- Trial name
- NCT04539028
- Testing
- Emergency Abdominal surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York Medical College
Neck Pain, Whiplash
PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
Neck pain-associated disorders (NAD) and whiplash-associated disorders (WAD) are major health problems. NAD has a lifetime prevalence of 54%.
- Conditions
- Neck Pain, Whiplash, Pain, Acute, Psychosocial Functioning
- Trial name
- NCT05468684
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- University of applied sciences
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Pain, Acute, Pain, Chronic
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
This clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population.
- Conditions
- Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries
- Trial name
- COLART (NCT05917925)
- Testing
- COLLAGEN (COL)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Pain, Postoperative, Breast Cancer
Using Bupivacaine Locally in the Mastectomy Drains to Control Postoperative Pain
in this study we are investigating the role of instillation of Bupivacaine through surgical drains at the end of mastectomy surgeries in controlling post operative pain and decreasing their pain killers requirement in the early…
- Trial name
- NCT03799757
- Testing
- 40ml of 0.25% bupivacaine, 40ml of 0.9% normal saline
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Alexandria University
Spinal Cord Injuries, Quadriplegia
Progressive Resistance Training in Acute Spinal Cord Injury
Muscle weakness is one of the most common and debilitating symptoms following a Spinal Cord Injury (SCI). Strength training is recommended as an effective means to increase muscular strength and improve function for individuals…
- Conditions
- Spinal Cord Injuries, Quadriplegia, Trauma, Nervous System, Paralysis
- Trial name
- NCT04265560
- Testing
- Progressive Resistance Training
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Glasgow Caledonian University
Spinal Cord Injury, Neurogenic Bladder
The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury
The purpose of this research study is to evaluate the effects upon the bladder of electric stimulation of the leg's tibial nerve in people with acute spinal cord injury with an intervention called transcutaneous tibial nerve…
- Trial name
- NCT02573402
- Testing
- Transcutaneous Tibial Nerve Stimulation, Control
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain Management, Thoracic Trauma
Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine
This study is a multicenter clinical trial conducted in Vinnytsia, Rivne, and Lviv, Ukraine, focusing on the management of acute pain following thoracic injuries sustained during combat.
- Conditions
- Pain Management, Thoracic Trauma, Pulmonary Function, Quality of Life
- Trial name
- CMS-APT-UA (NCT07380789)
- Testing
- Cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Lviv National Medical University
Spinal Cord Trauma, Pain
Study of Pregabalin in the Prevention of Central Neuropathic Pain in Acute Spinal Cord Injury
This research study will test to see if people who receive pregabalin after their spinal cord injury will develop less nerve damage pain than people who do not receive it.
- Trial name
- NCT00879021
- Testing
- Lyrica
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority