Clinical trials: Acute Neurological Injury, open to volunteers
Acute Pain, Pediatric ALL
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR).
- Conditions
- Acute Pain, Pediatric ALL, Procedural Pain, Burns
- Trial name
- NCT06303687
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
PTSD, Chronic Pain
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain.
- Trial name
- NCT05700279
- Testing
- Stellate Ganglion Block, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Rush University Medical Center
Isquemic Stroke, Upper Limb Weakness Due to Central Neurologic Injury
Effectiveness of m-CIMT of the Upper Limb in Acute Post-stroke Patients. (m-CIMT, Modified Constraint-induced Movement Therapy)
m-CIMT therapy is the restriction of the unaffected upper extremity in conjunction with an upper extremity specific exercise protocol to improve the functionality and use of the affected upper extremity.
- Trial name
- m-CIMT (NCT07233161)
- Testing
- m-CIMT
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Traumatic Brain Injury
Promoting Neuroplastic Changes of Patients With TBI
This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage…
- Trial name
- NCT06465290
- Testing
- Motor relearning training with wearable ankle robot, Passive stretching with wearable ankle robot, Gamed-based active movement training with wearable ankle robot
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Pain Management, Thoracic Trauma
Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine
This study is a multicenter clinical trial conducted in Vinnytsia, Rivne, and Lviv, Ukraine, focusing on the management of acute pain following thoracic injuries sustained during combat.
- Conditions
- Pain Management, Thoracic Trauma, Pulmonary Function, Quality of Life
- Trial name
- CMS-APT-UA (NCT07380789)
- Testing
- Cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Lviv National Medical University
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Traumatic Rib Fracture(s), Traumatic Rib Fracture
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures
Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid…
- Trial name
- NCT07756047
- Testing
- Erector spinae plane catheter, Serratus plane catheter
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Sunnybrook Health Sciences Centre
Burns, Pain, Acute
A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes
Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes.
- Trial name
- NCT03695887
- Testing
- Nitrous Oxide Inhalant Product
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage (ICH)
Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury
Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain.
- Trial name
- SPRINT (NCT07794605)
- Where
- 2 sites in United States
- Volunteers
- 230 people
- Sponsor
- Columbia University
Fecal Incontinence
Acute Genital Nerve Stimulation for Neurogenic Bowel Dysfunction in Individuals Living With Spinal Cord Injury
Bowel issues occur in nearly all people after spinal cord injury (SCI) and one major complication is fecal incontinence (accidents).
- Trial name
- NCT05626816
- Testing
- Genital Nerve Stimulation, Clinical exam, Collection of SCI common data elements
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries (SCI)
Spasticity in SCI Following Acute Intermittent Hypoxia
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury.
- Trial name
- NCT07583498
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Zev Rymer
Trauma, Acute Pain
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium.
- Trial name
- NCT04166877
- Testing
- Magnesium Sulfate in Parenteral Dosage Form
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of California, Davis
Emergency, Point of Care Ultrasound (POCUS)
Italian Data Registry of Patients Undergoing Peripheral Nerve Block Performed in the Emergency Departments
This data registry aim is to describe the practice of Point-of-Care Ultrasound Guided Regional Anaesthesia (POCUS-GRA) in emergency departments of nosocomial hospitals where, the organizational structure, has already provided for…
- Conditions
- Emergency, Point of Care Ultrasound (POCUS), Anesthesia, Acute Pain
- Trial name
- ED-RA (NCT06707558)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
D000784, D020521
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection
Aortic dissection is a life-threatening condition and a consequence of a tear of the innermost of the three aortic layers- the intima.
- Trial name
- CARTA (NCT04962646)
- Testing
- Carbon dioxide flooding
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Intracerebral Hemorrhage
Short-term And Longer-term Cognitive Impact Of Neurochecks
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI).
- Trial name
- NCT06219889
- Testing
- Frequency of neurochecks
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Traumatic Spinal Cord Injury
Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury
The objective of this clinical trial is to evaluate if early detection of spasticity and immediate treatment with oral baclofen during acute care prevents problematic spasticity and improves neurofunctional recovery after tSCI.
- Trial name
- NCT06564714
- Testing
- Early baclofen Intervention, Usual routine care
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Wrist Injuries, Wrist Fracture
Splinted Wrist Study
Randomized clinical trial comparing SAM aluminium splint vs pain relief as usual in patients seeking emergency department care for suspected wrist fractures.
- Conditions
- Wrist Injuries, Wrist Fracture, Pain, Acute
- Trial name
- NCT07553000
- Testing
- SAM splint
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane