Clinical trials: Acute Non-ST Elevation Myocardial Infarction
Non ST-elevation Myocardial Infarction
Brilinta Taiwan Post Approval Safety Study
A multicenter, single arm, open label, Phase IV study to evaluate safety and to describe the cumulative incidence of major cardiovascular events of Ticagrelor in Taiwanese patients with non ST-segment (a segment in the…
- Trial name
- NCT02406248
- Testing
- Ticagrelor 180mg loading dose taken orally, followed by 90mg twice daily (bd)
- Where
- 13 sites in Taiwan
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
Unstable Anginas, Non ST Segment Elevation Myocardial Infarction
OCT Evaluation of Early Vascular Repair in Patients With Non ST Elevation Acute Coronary Syndrome (NSTE-ACS)
This is a prospective study of a new generation of drug-eluting stent in the treatment of non ST elevation acute coronary syndrome (NSTE-ACS).
- Trial name
- EXPECT (NCT04375319)
- Testing
- OCT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xuzhou Third People's Hospital
Non-ST Segment Elevation Myocardial Infarction, ST Segment Elevation Myocardial Infarction
Comparison of Clopidogrel and Ticagrelor on Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction
Ticagrelor is a non-thienophyridine, direct P2Y12 blocker that is more potent than clopidogrel and is associated with less interindividual variability.
- Trial name
- NCT02026219
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Inha University Hospital
Non-ST Elevation Myocardial Infarction
Routinely Deferred Versus Early Intervention in Elderly Patients With Non-ST-elevation Myocardial Infarction
This study is to evaluate the efficacy and safety of a routinely deferred invasive strategy in comparison with an early invasive strategy in Chinese elderly patients of 75 years or older with non-ST elevation myocardial…
- Trial name
- DEAR-OLD (NCT02900001)
- Testing
- early coronary angiography, delayed coronary angiography
- Where
- China
- Volunteers
- 696 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
ST Elevation Myocardial Infarction, Non ST Elevation Myocardial Infarction
Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry
The CLEAR SYNERGY trial will study the long term effects of treatments following PCI to treat myocardial infarction. These treatments address both the culprit artery (PCI with SYNERGY stent) as well as the non-culprit arteries…
- Trial name
- CLEAR SYNERGY (NCT03048825)
- Testing
- Colchicine, Spironolactone, SYNERGY Bioabsorbable Polymer Drug-Eluting Stent
- Where
- 109 sites in United States, Australia and 12 more
- Volunteers
- 7,264 people
- Sponsor
- Population Health Research Institute
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
Acute Coronary Syndromes, STEMI
Early Single Antiplatelet Therapy After IVUS-Guided PCI in Acute Coronary Syndrome
This is a prospective, open-label, multicenter, randomized, phase IV clinical trial designed to evaluate the safety and efficacy of early aspirin discontinuation followed by potent P2Y12 inhibitor monotherapy after intravascular…
- Conditions
- Acute Coronary Syndromes, STEMI, NSTEMI, Unstable Angina
- Trial name
- SAPT-ACS (NCT07684742)
- Testing
- Early P2Y12 Inhibitor Monotherapy, Standard Dual Antiplatelet Therapy
- Where
- South Korea
- Volunteers
- 1,900 people
- Sponsor
- Gyeongsang National University Hospital
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Infarction, Ischemia
CMR in the Assessment of Patient With ACS in the Emergency Room
In this study, we investigate the role of Cardiac Magnetic Resonance Imaging in patients with suspected, but not yet proven, "acute cardiac syndrome ACS".
- Conditions
- Infarction, Ischemia, Magnetic Resonance Imaging
- Trial name
- NCT00564382
- Testing
- Cardiac magnetic Resonance study
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
STEMI, NSTEMI
Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome
The ELECTRA-SIRIO 2 study is a randomized, multicenter, double-blind, investigator-initiated clinical trial aimed to evaluate safety and efficacy of two ticagrelor-based de-escalation antiplatelet strategies in patients with…
- Conditions
- STEMI, NSTEMI, Unstable Angina
- Trial name
- ELECTRA-SIRIO (NCT04718025)
- Testing
- Ticagrelor 90mg, Ticagrelor 60mg, Aspirin
- Where
- Poland
- Volunteers
- 4,500 people
- Sponsor
- Collegium Medicum w Bydgoszczy
NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Acute Myocardial Infarction (AMI)
Treatment With Aspirin Alone Versus Aspirin in Combination With Fondaparinux Before Early Coronary Assessment in Patients With Non-ST-Elevation Myocardial Infarction
The main goal of this study is to compare two treatments in patients with a specific type of heart attack called Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- FOXY (NCT06710184)
- Testing
- Aspirin, Fondaparinux Sodium
- Where
- 10 sites in Denmark
- Volunteers
- 5,076 people
- Sponsor
- University of Aarhus
Non ST Segment Elevation MI and Unstable Angina
Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction (NSTEMI) Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention (PCI)
Patients with NSTEMI and multivessel disease will be scheduled to undergo early invasive strategy (PCI within 72 hours) of de novo native coronary artery lesions were considered for recruitment into the study.
- Trial name
- SMILE (NCT01478984)
- Testing
- One-Stage group, Multi-Staged group
- Where
- Italy
- Volunteers
- 247 people
- Sponsor
- Gennaro Sardella
Non-ST Elevation Myocardial Infarction, Frail Elderly Syndrome
the Invasive and Conservative Strategies in Elderly Frail Patients With Non-STEMI
The role of a routine invasive strategy in frail patients with non-ST-segment elevation acute myocardial infarction is currently uncertain. We hypothesize that a routine invasive strategy will improve outcomes.
- Trial name
- MOSCA-FRAIL (NCT03208153)
- Testing
- Invasive, Conservative
- Where
- Spain
- Volunteers
- 167 people
- Sponsor
- University of Valencia
Coronary Artery Disease, Stable Angina
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
Prospective, multi-center, registry designed to enrol up to 2,000 patients in up to 35 International centers. All patients will receive a BioMatrix AlphaTM stent as per clinical practice and will be followed for 2 years for data…
- Conditions
- Coronary Artery Disease, Stable Angina, Ischemia, Acute Coronary Syndrome
- Trial name
- NCT02871622
- Testing
- BioMatrix AlphaTM
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Biosensors Europe SA
Coronary Stenosis, Acute Coronary Syndrome
Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes
The aim of Multiplaque clinical study is to assess the vulnerability degree of the atheromatous plaques, before and after a myocardial infarction (MI), based on multiomics analysis, associated with invasive and non-invasive data.
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- MultiPlaque (NCT03391908)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
ASCVD, NSTEMI
Telehealth Group Counseling and Preventive Care for Women
The purpose of this study is to utilize an innovative healthcare delivery strategy via telehealth group counseling sessions to improve engagement, adherence, and ultimately outcomes in female patients with atherosclerotic…
- Conditions
- ASCVD, NSTEMI, STEMI, Coronary Artery Disease
- Trial name
- NCT06404515
- Testing
- Telehealth Group Counseling
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Myocardial Infarction
Post STEMI Echo Registry
This is a prospective observational study of consecutive patients presenting with STEMI to the Prince of Wales Hospital over a 12-month period.
- Trial name
- NCT05551065
- Testing
- Point-of-care ultrasound (POCUS)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Acute Myocardial Infarction
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?
Rationale: A safety and dose defining study in which the investigators hypothesize that in patients with acute coronary syndrome without ST-elevation (NSTEMI) treatment with heme arginate results in better clinical outcome by…
- Trial name
- HAEM (NCT00483587)
- Testing
- Heme arginate
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen