Clinical trials: Acute Pain, injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Condition Acute Pain
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Acute Pain, Opioid Use
CPB for Arthroscopic Hip Surgery
Arthroscopic hip surgery is being increasingly performed to treat both intraarticular and extraarticular hip diseases. Despite the minimally invasive approach, patients undergoing arthroscopic hip surgery still suffer severe pain…
- Trial name
- NCT06337968
- Testing
- Circum-psoas Block
- Volunteers
- 74 people
- Sponsor
- The Second Hospital of Shandong University
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Postoperative Acute Pain
Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy
A single-center, randomized, double-blind, placebo-controlled trial design will be adopted to investigate whether Anruikefon can significantly reduce the consumption of sufentanil via PCIA pumps within 48 hours postoperatively…
- Trial name
- NCT07801183
- Testing
- Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gender Affirming Surgery, Mastectomy
Gender Affirming Mastectomy Analgesia Rial
Introduction: Optimizing pain management after gender-affirming mastectomy (removal of breast tissue, aka top surgery) surgery is important for recovery and minimizing opioid use.
- Conditions
- Gender Affirming Surgery, Mastectomy, Acute Pain
- Trial name
- GAMA (NCT07861165)
- Testing
- Paravertebral (single injection), Wide local infiltration
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Nova Scotia Health Authority
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Vaso-Occlusive Pain Episode in Sickle Cell Disease
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease
The purpose of the study is to determine whether adding lidocaine to standard of care in pain management during severe vaso-occlusive crisis has an effect on the cumulative opioid consumption expressed as morphine milligram…
- Trial name
- LidoVOC (NCT07274254)
- Testing
- Lidocain, Standard of care
- Where
- 12 sites in France, Guadeloupe
- Volunteers
- 104 people
- Sponsor
- Nantes University Hospital
Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis
Buprenorphine for the Management of Pain in Children With Sickle Cell Disease
The goal of this clinical trial is to learn whether a single dose of buccal buprenorphine (BELBUCA) is safe when used in place and/or with full agonist opioids that would otherwise be started during a sickle cell pain crisis…
- Conditions
- Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis, Sickle Cell Anemia Crisis, Sickle Cell Anemia in Children
- Trial name
- NCT07799571
- Testing
- Buprenorphine Buccal Film [Belbuca]
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Natasha Archer
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Postoperative Pain, Postoperative Acute Pain
Comparative Analysis of the Impact of Transversus Abdominis Plane Block on Post-Cesarean Pain Management Using Low Concentration Ropivacaine 0,2%
The goal of this clinical trial is to evaluate whether the addition of a Transversus Abdominis Plane (TAP) block improves postoperative outcomes in women undergoing cesarean section.
- Trial name
- NCT07604376
- Testing
- Postoperative analgesia using TAP block, Ropivacaine 0,2%, volume: 0,4 ml/kg per side, Postoperative pain management using "traditional" analgesia iv regime
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Matild Keresztes
Acute Pain, Abdomen, Acute
Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain
Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly.
- Conditions
- Acute Pain, Abdomen, Acute, Abdominal Pain, Appendicitis
- Trial name
- KETOAPP (NCT06160778)
- Testing
- Ketorolac Tromethamine, Morphine Sulfate, normal saline
- Where
- Canada
- Volunteers
- 495 people
- Sponsor
- University of Calgary
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Acute Postoperative Pain, Surgery
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty.
- Trial name
- NCT06784882
- Testing
- continuous peripheral nerve block with OnQ pump, single injection nerve block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Colectomy, Open Surgery
Perioperative Intravenous Nimodipine Trial
The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity…
- Conditions
- Colectomy, Open Surgery, Pain, Pain, Postoperative
- Trial name
- NCT07048522
- Testing
- Nimodipine, Isotonic Saline
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Ioannina
Cardiac Anaesthesia, Chronic Pain
Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery
The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing…
- Conditions
- Cardiac Anaesthesia, Chronic Pain, Post Operative Pain, Chronic, Post Operative Pain, Acute
- Trial name
- NCT07490457
- Testing
- Ketamine group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Obesity, Bariatric Surgery
Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy
Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium.
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy, Acute Post Operative Pain
- Trial name
- NCT06515691
- Testing
- M-TAPA block, Postoperative pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Postoperative Pain, Acute, Lung Cancer
Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine
This randomized controlled trial evaluates the analgesic effects of liposomal bupivacaine compared to bupivacaine hydrochloride in intercostal nerve block for patients undergoing thoracoscopic lung surgery.
- Trial name
- NCT07134660
- Testing
- Liposomal Bupivacaine intercostal nerve block, Bupivacaine Hydrochloride intercostal nerve block, Standard Postoperative Analgesia
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block
Comparison of Postoperative Analgesic Efficacy of Transversus Abdominis Plane Block (TAP) and Modified Thoracoabdominal Nerve Block (M-TAPA)
Laparoscopic cholecystectomy is a frequently performed surgical procedure and is considered the gold standard for treating symptomatic gallstone disease.
- Conditions
- Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Trial name
- NCT06932835
- Testing
- Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Perioperative Pain in Robotic Prostatectomy
Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy
Tramadol and magnesium have already been researched in recent decades for their different roles in pain control. This clinical study will compare and re-evaluate their effect on the duration and quality of analgesia provided by a…
- Trial name
- NCT07289321
- Testing
- Ultrasound - guided bilateral transversus abdominis plane block (TAP) in patients undergoing robotic-assisted radical prostatectomy.
- Where
- Greece
- Volunteers
- 105 people
- Sponsor
- Aretaieion University Hospital