Clinical trials: Acute Pain
Acute Pain, Fractures
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Opioid pain medications such as morphine and dilaudid are commonly used in emergency departments to treat pain in patients. Physicians are familiar with the side effects of these medications; the most concerning of which is…
- Trial name
- NCT02430818
- Testing
- ketamine, morphine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Total Knee Arthroplasty
Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?
We are investigating the impact of duloxetine ("Cymbalta"), a serotonin and norepinephrine reuptake inhibitor, on pain after total knee arthroplasty (TKA).
- Trial name
- NCT02005601
- Testing
- Duloxetine 60mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Hospital for Special Surgery, New York
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Migraine
Initiating Early Control of Migraine Pain and Associated Symptoms
AXS-07 is an oral, investigational medicine consisting of MoSEIC meloxicam and rizatriptan, which is being developed for the acute treatment of migraine with or without aura in adults.
- Trial name
- INTERCEPT (NCT04163185)
- Testing
- AXS-07 (MoSEIC meloxicam and rizatriptan)
- Where
- 41 sites in United States
- Volunteers
- 302 people
- Sponsor
- Axsome Therapeutics, Inc.
Pain, Acute
Adult Oral Ibuprofen Study for ED Pain Patients
Ibuprofen is one of the most widely used non-steroidal anti-inflammatory drug (NSAID) for management of mild -to moderate pain in the ED (acute musculo-skeletal pain, headache, dental pain).
- Trial name
- NCT03441269
- Testing
- Oral Ibuprofen
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Antonios Likourezos
Pain
Intravenous Lidocaine and Ketorolac for Pain Management
The literature regarding analgesic modalities, their combinations and routes of administrations for patients with pain related to renal colic is expanding.
- Trial name
- NCT02902770
- Testing
- Lidocaine, Ketorolac Tromethamine, Normal Saline Drip
- Volunteers
- 150 people
- Sponsor
- Antonios Likourezos
Sub-acute Back Pain
Effect of L-dopa In Subacute Back Pain Population
This study aims to determine if early treatment with Carbidopa/Levodopa and Naproxen in individuals with sub-acute back pain (SBP) is associated with changes in blocking transition to chronic back pain (CBP).
- Trial name
- NCT01951105
- Testing
- Naproxen, Carbidopa/Levodopa
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Chronic Migraine
A Study of Remote Electrical Neuromodulation for Acute Procedural Pain
The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine…
- Trial name
- NCT05730556
- Testing
- Nerivio ®
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Pain, Postoperative
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The objective of this study is to evaluate the safety and clinical utility of the active, SSEC fentanyl 40 micrograms (mcg) for the management of acute, postoperative pain in pediatric participants.
- Trial name
- NCT02395653
- Testing
- fentanyl
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- The Medicines Company
Acute Non-complicated Postural Neck Pain
The Effect of TheraBand® Kinesiology Tape on Post-manipulation Pain and Range of Motion
The purpose of this study is to determine if post-manipulation elastic therapeutic tape (ETT) with TheraBand® Kinesiology Tape to neck pain patients can impact neck range of motion (ROM) and post-manipulation pain.
- Trial name
- TBKTManip (NCT02691143)
- Testing
- TheraBand Kinesiology Tape
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Acute Pain
Safety and Efficacy of Sufentanil NanoTab for Management of Acute Pain Following Bunionectomy
This is a dose-finding study to determine if the sublingual administration of the Sufentanil NanoTab is safe and effective in the treatment of post-operative pain.
- Trial name
- NCT01710345
- Testing
- Sufentanil NanoTab 20 mcg, Sufentanil NanoTab 30 mcg
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Talphera, Inc
Pain Management
IBUPAP Study for Pain Management in Children
Current literature supports ibuprofen and APAP are the most commonly used analgesics in the pediatric ED for acute traumatic/non-traumatic pain.
- Trial name
- NCT03088800
- Testing
- Ibuprofen, APAP
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Antonios Likourezos
Pain, Acute, Dissociation
Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects
This will be an intent to treat prospective, double blind, double-dummy, randomized trial. Our primary objective is the reduction of side effects of sub dissociative dose ketamine given by slow intravenous (IV) infusion over 30…
- Trial name
- NCT05518877
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Summa Health System
Low Back Pain
Ibuprofen With or Without Acetaminophen for Low Back Pain
This is a randomized clinical trial comparing two interventions for acute low back pain: 1. Ibuprofen + acetaminophen 2. Ibuprofen + placebo Participants will include patients who present to an emergency room for management of…
- Trial name
- NCT03554018
- Testing
- Acetaminophen, Ibuprofen 600 mg, Educational intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Montefiore Medical Center
Pain
Prospective, Randomized, Non-inferiority Investigation to Compare Effects of Mepitel® One and UrgoTul® Dressings in Acute Wound Management (Only)"
To compare the effects of pain of the two dressings, Mepitel® One and UrgoTul® in acute wound management.
- Trial name
- Only (NCT02237118)
- Testing
- Mepitel One, UrgoTul
- Where
- France
- Volunteers
- 123 people
- Sponsor
- Molnlycke Health Care AB
Acute Pain, Chronic Pain
Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery.
- Conditions
- Acute Pain, Chronic Pain, Hernia, Anesthesia, Intravenous
- Trial name
- NCT02527083
- Testing
- Propofol, Sevoflurane, Remifentanil
- Volunteers
- 10 people
- Sponsor
- VA Pittsburgh Healthcare System
Osteoarthritis, Postoperative Pain
Acute Pain Genomic Study
In preparation for future large-scale genome wide association studies, reliable methods must be developed for measuring perceived pain and for estimating the effects of potentially confounding factors such as appropriate…
- Trial name
- NCT01557751
- Testing
- Whole blood for genotyping
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pittsburgh
Acute Pain, Analgesia
Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers
To determine if baclofen will enhance buprenorphine analgesia for acute pain in healthy volunteers.
- Trial name
- NCT04251819
- Testing
- Baclofen 5 mg, Baclofen 10mg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Musculoskeletal Pain
Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg…
- Trial name
- NCT03173456
- Testing
- oxycodone/APAP, hydrocodone/APAP, codeine/APAP
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine