Clinical trials: Acute Pain
Acute Pain
Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery
The purpose of this study is to determine the effectiveness and safety of single intravenous doses of the kappa opioid agonist CR845 in relieving pain in patients following laparoscopic-assisted hysterectomy surgery.
- Trial name
- NCT00877799
- Testing
- CR845
- Where
- 12 sites in United States
- Volunteers
- 114 people
- Sponsor
- Cara Therapeutics, Inc.
Urolithiasis
Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain
STUDY OBJECTIVE: This randomized, controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of acute flank pain.
- Trial name
- NCT01318187
- Testing
- paracetamol, morphine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Pamukkale University
Low Back Pain
Muscle Energy Technique Versus Back Stretching Among Non-specific Low Back Pain-subacute
This study will highlight LBP management using MET and stretching application among subacute type of back pain
- Trial name
- NCT05360121
- Testing
- Muscle energy technique of erector spinae muscle, Muscle energy technique of quadratus lumborum muscle, Stretching of erector spinae muscle
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Chronic Myeloproliferative Disorders, Leukemia
Treatment for Chronic Pain in Patients With Advanced Cancer
RATIONALE: Different drug formulations and combinations of drugs may help patients with chronic pain live more comfortably. It is not yet known which regimen is most effective for chronic pain.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003687
- Testing
- dextromethorphan hydrobromide, morphine sulfate
- Where
- 4 sites in Canada
- Volunteers
- 87 people
- Sponsor
- NCIC Clinical Trials Group
Pain, Osteoarthritis
Reliability of Pupil Response to Acute Pain
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced.
- Trial name
- NCT02628314
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Rib Fracture(s), Traumatic Rib Fracture
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures
Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid…
- Trial name
- NCT07756047
- Testing
- Erector spinae plane catheter, Serratus plane catheter
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Sunnybrook Health Sciences Centre
Toothache
SB-705498 Dental Pain Study After Tooth Extraction
This clinical trial is a multi centre, randomised, single-blind, parallel group, placebo-controlled, single oral dose study with a positive control arm.
- Trial name
- NCT00281684
- Testing
- SB705498 400 mg, SB705498 1000 mg, Co-Codamol
- Where
- 5 sites in Italy, South Korea and 1 more
- Volunteers
- 145 people
- Sponsor
- GlaxoSmithKline
Brain Tumor
Brain Tumor Surgery and Postoperative Delirium
1. To explore whether the combined administration of dexmedetomidine during and after surgery in patients undergoing brain tumor resection is an effective and safe modality to prevent postoperative delirium and improve sleep…
- Trial name
- NCT06863064
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Abdomen, Acute, Surgery--Complications
Survival After Emergency Laparotomy in Octogenarians
In this single-center retrospective study we wanted to investigate mortality and postoperative complications after emergency laparotomy performed in patients aged 80 years or above.
- Conditions
- Abdomen, Acute, Surgery--Complications, Postoperative Complications, Frailty
- Trial name
- NCT04176432
- Testing
- No intervention
- Volunteers
- 106 people
- Sponsor
- Haukeland University Hospital
Coronary Artery Disease, Stable Angina
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
Prospective, multi-center, registry designed to enrol up to 2,000 patients in up to 35 International centers. All patients will receive a BioMatrix AlphaTM stent as per clinical practice and will be followed for 2 years for data…
- Conditions
- Coronary Artery Disease, Stable Angina, Ischemia, Acute Coronary Syndrome
- Trial name
- NCT02871622
- Testing
- BioMatrix AlphaTM
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Biosensors Europe SA
Acute Pain, Surgery
Comparison of Epidural and TAP Block in Abdominal Surgery
This study will compare the infiltrative transversusabdominis plane (TAP) block with liposomal bupivacaine to epidural analgesia (EA) in major abdominal surgery .
- Conditions
- Acute Pain, Surgery, Regional Anesthesia
- Trial name
- NCT01848951
- Testing
- Epidural, TAP Block
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Nebraska
Postoperative Pain, Cholelithiasis
Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) )
This randomized controlled clinical trial investigates the comparative efficacy of two novel regional anesthesia techniques - the Erector Spinae Plane Block (ESPB) and the External Oblique Intercostal Plane Block (EOPB) - for…
- Conditions
- Postoperative Pain, Cholelithiasis, Acute Pain
- Trial name
- NCT07057934
- Testing
- ESPB Block, EOPB Block, Standard Systemic Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Posoperativ Pain, Chronich Pain
Opioid-Free Anesthesia and Pain Study in Cardiac Surgery Patients
The goal of this clinical trial is to compare the effect of opioid-free anesthesia on the intensity of acute and chronic postoperative pain in patients undergoing cardiac surgery.
- Conditions
- Posoperativ Pain, Chronich Pain, Postoperativ Delirum, Opoid-free Managment
- Trial name
- OFPAINS-CS (NCT07618130)
- Testing
- Opioid Free Anaesthesia, Opioid Anesthesia
- Where
- Serbia
- Volunteers
- 400 people
- Sponsor
- Clinical Centre of Serbia
Postoperative Pain, Thoracic Surgery
Analgesia With Transdermal Buprenorphine Patch in Adults Undergoing Video-Assisted Thoracoscopic Surgery
Postoperative pain remains a major challenge after video-assisted thoracoscopic surgery (VATS), despite the use of multimodal analgesia.
- Conditions
- Postoperative Pain, Thoracic Surgery, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT07733128
- Testing
- Buprenorphine (BUP)
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Clínica Dávila
Acute Pain, Total Hip Arthroplasty
Auricular Acupuncture for Analgesia During Total Hip Arthroplasty
The aim is to investigate whether auricular acupuncture is superior to sham acupuncture in relief of acute pain and in reduction of analgesics in patients during total hip arthroplasty
- Trial name
- NCT00334165
- Testing
- Auricular acupuncture (procedure)
- Where
- 2 sites in Germany
- Volunteers
- 360 people
- Sponsor
- University Medicine Greifswald
Mastectomy, Segmental, Acute Pain
Evaluation of a Breast Biblock Analgesia for the Mastectomy With Radical Axillary Lymphadenectomy Surgery
This study evaluates the efficacy of the the pecto-intercostal fascial plane block (PIF block) for the anesthesia of the intercostal nerves anterior branches and assesses the association of the serratus block with a PIF block for…
- Conditions
- Mastectomy, Segmental, Acute Pain, Anesthesia
- Trial name
- NCT02963857
- Volunteers
- 9 people
- Sponsor
- Maison de Santé Prostestante de Bordeaux Bagatelle
Acute Post-operative Pain, Cholecystectomy, Laparoscopic
Optimizing Pain Management Following Laparoscopic Cholecystectomy RCT
evaluating the two final steps we added to optimize post laparoscopic cholecystectomy pain management.
- Conditions
- Acute Post-operative Pain, Cholecystectomy, Laparoscopic, Pain Assessment Pain Intensity, Pain Intensity
- Trial name
- Pain (NCT05214157)
- Testing
- active gas aspiration
- Where
- Egypt
- Volunteers
- 804 people
- Sponsor
- Zagazig University
Mouth and Tooth Diseases, Tooth, Impacted
Ketamine on Acute Pain in Females and Males
The purpose of the study is to determine whether equal subanesthetic doses of racemic ketamine is equally effective on females and males after surgical removal of third molars
- Trial name
- NCT00232492
- Testing
- Ketamine 0,1 mg/kg males, Ketamine 0,3 mg/kg males, Ketamine 0,5 mg/kg males
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Ullevaal University Hospital
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Migraine Headache
Safety & Efficacy of a Single Dose of Sumatriptan Powder Delivered Intranasally With the Bi-directional Device in Adults With Acute Migraine
The study is being conducted to determine if OPTINOSE SUMATRIPTAN delivered nasally (through the nose) using the OPTINOSE SUMATRIPTAN Device can reduce the pain and symptoms associated with migraine headaches.
- Trial name
- NCT01462812
- Testing
- Sumatriptan
- Where
- 15 sites in United States
- Volunteers
- 223 people
- Sponsor
- Optinose US Inc.