Clinical trials: Acute Pancreatitis Necrotizing
Acute Necrotizing Pancreatitis, Portosplenomesenteric Venous Thrombosis
Acute Pancreatitis and Thrombosis (PATHRO)
Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of…
- Trial name
- PATHRO (NCT04642794)
- Testing
- observational study
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Nantes University Hospital
Pancreatic Fluid Collection, Walled-off Necrosis
Immediate Necrosectomy vs. Step-up Approach for Walled-off Necrosis
Walled-off necrosis (WON) is a pancreatic fluid collection, which contains necrotic tissue after four weeks of the onset of acute pancreatitis.
- Conditions
- Pancreatic Fluid Collection, Walled-off Necrosis, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst
- Trial name
- WONDER-01 (NCT05451901)
- Testing
- Immediate necrosectomy, Step-up approach
- Where
- 21 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Tokyo University
Acute Pancreatitis With Uninfected Necrosis, Unspecified
Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis
Mortality from severe acute pancreatitis reaches 42%. The prognosis of acute pancreatitis is associated with the development of acute inflammatory response syndrome (SIRS) and multiple organ failure (MOF).
- Trial name
- NCT05695001
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 34 people
- Sponsor
- Efferon JSC
Acute Pancreatic Necrosis, Acute Pancreatitis
EndoRotor DEN (Direct Endoscopic Necrosectomy)Trial
A prospective, single arm, open label, multi-center, trial to evaluate the safety and effectiveness of the Interscope EndoRotor® Resection System in subjects requiring direct endoscopic necrosectomy (DEN) with walled off…
- Conditions
- Acute Pancreatic Necrosis, Acute Pancreatitis, Necrotizing Pancreatitis
- Trial name
- NCT03694210
- Testing
- EndoRotor Therapy
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 30 people
- Sponsor
- Interscope, Inc.
Pancreatic Necrosis
Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)
Walled-off pancreatic necrosis (WON) is associated with a mortality of 20-30%. The current evidence supports a minimally invasive drainage approach to infected WON.
- Trial name
- NCT05252897
- Testing
- Endoscopic necrosectomy with step up approach, Endoscopic necrosectomy with direct approach
- Where
- 9 sites in Australia, Hong Kong and 4 more
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Pancreatitis, Acute, Pancreatitis, Acute Necrotizing
The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.
The goal of this clinical trial is to learn about clinical usefulness of double pigtail plastic stents during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of…
- Conditions
- Pancreatitis, Acute, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06134024
- Testing
- Introduction of double pigtail plastic stents through the LAMS during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections, Endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of LAMS only
- Volunteers
- 200 people
- Sponsor
- Nicolaus Copernicus University
Acute Pancreatitis
A Novel Surgical Strategy to Reduce Major Complications in Patients With Necrotizing Pancreatitis
The goal of this observational study is to compare patient outcomes between the groups of patients admitted before and after the full implementation of the novel surgical strategy in patients with necrotizing pancreatitis.
- Trial name
- NCT06241586
- Testing
- The novel PMMI surgical strategy, The conventional step-up strategy
- Where
- China
- Volunteers
- 271 people
- Sponsor
- Tianjin Nankai Hospital
Acute Pancreatitis
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
The purpose of the study is to identify novel blood-based biomarkers for prediction and diagnosis of infected pancreatic necrosis (IPN) in patients with necrotizing pancreatitis (NP).
- Trial name
- NCT06899087
- Testing
- not interventional
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Acute Necrotizing Pancreatitis
Significance of Collections Around Colon in Patients With Acute Necrotizing Pancreatitis
Acute pancreatitis is an inflammatory process which causes a local and systemic inflammatory response syndrome (SIRS). Although the majority of patients have a mild disease course, around 20% will develop moderate or severe…
- Trial name
- NCT03411629
- Where
- India
- Volunteers
- 44 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Post-ERCP Pancreatitis, Pancreatitis, Acute Necrotizing
The Efficacy of Pancreatic Duct Stenting With Rectal Indomethacin in Preventing Post-ERCP Pancreatitis
With the development of endoscopic technology, ERCP has been widely used in the diagnosis and treatment of pancreatobiliary diseases, and has become the first treatment for most of the biliary and pancreatic diseases.
- Trial name
- NCT03643900
- Testing
- pancreatic duct stenting, rectal indomethacin
- Where
- China
- Volunteers
- 618 people
- Sponsor
- First People's Hospital of Hangzhou
Infected Pancreatic Necrosis, Acute Pancreatic Fluid Collection
Comparison of FCSEMS and Plastic Stents
The research design is a randomized prospective clinical trial comparing Endoscopic ultrasound (EUS) guided drainage of WON using FCSEMS and plastic stents.
- Conditions
- Infected Pancreatic Necrosis, Acute Pancreatic Fluid Collection, Pancreatic and Peripancreatic Necrosis, Pancreatic Collection
- Trial name
- WON-MVP (NCT02685865)
- Testing
- FCSEM Stent, Plastic Stent
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- AdventHealth
Acute Pancreatitis, Pancreatic Pseudocyst
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant…
- Conditions
- Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06179459
- Testing
- Endoscopic management of pancreatic fluid collections
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Orlando Health, Inc.
Acute Pancreatitis
Imipenem Prophylaxis in Patients With Acute Pancreatitis
This is a prospective, single-center, randomized, placebo-controlled, double-blind clinical trial that aims to investigate the beneficial and harmful effects of prophylactic use of imipenem in patients with predicted severe acute…
- Trial name
- IMPROWE (NCT02897206)
- Testing
- Imipenem
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- University Hospital Rijeka
Pancreatitis, Pancreatitis, Acute Necrotizing
Etiology, Clinical Picture, Complications and Outcomes of Necrotizing Pancreatitis in Children.
The aim of this research is to study the etiology, the clinical picture, the management, the complications and the outcomes of necrotic pancreatitis in children.
- Conditions
- Pancreatitis, Pancreatitis, Acute Necrotizing, Children
- Trial name
- NCT06700330
- Testing
- no intervention, observational study
- Where
- Russia
- Volunteers
- 102 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Acute Pancreatitis
Pentoxifylline Treatment of Acute Pancreatitis
The purpose of this study is to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis, to see if it can improve blood tests associated with inflammation (tissue damage).
- Trial name
- NCT01292005
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Acute Necrotizing Pancreatitis
Tracking ENcapsulation of Pancreatic Collections in Acute Necrotizing Pancreatitis
The goal of this study is to investigate the encapsulation of fluid collections in patients with ANP using serial MRI. The main questions it aims to answer are: Evaluating the timing of encapsulation of necrotic fluid collection…
- Trial name
- NCT05716633
- Testing
- MRI
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP)
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis
The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis.
- Conditions
- Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP), Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT07395778
- Testing
- endoscopic ultrasonography guided cystogastrostomy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Pancreatitis Necrotizing, Nutrition Assessment
PERT in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, we propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERT-ANP (NCT07211568)
- Testing
- Pancreatic Enzyme Replacement Therapy
- Volunteers
- 188 people
- Sponsor
- Asian Institute of Gastroenterology, India