Clinical trials: Acute Phase Response
Respiratory Syncytial Virus Infections
A Study on the Immune Response, Safety and the Occurrence of Respiratory Syncytial Virus (RSV)-Associated Respiratory Tract Illness After Administration of RSV OA Vaccine in Adults 60 Years and Older
The purpose of the current study is to evaluate the immune response of the RSVPreF3 OA investigational vaccine in older adults (OA) at least (>=) 60 years of age (YOA) in China compared to OA in the same age range to be enrolled…
- Trial name
- NCT06551181
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 40 sites in China, Finland and 5 more
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Surgery, Acute Phase Reaction
Neuroinflammation and Cognitive Dysfunction After Orthopedic Surgery
The primary hypothesis that orthopaedic surgery induces a neuroinflammatory response within 48 hours after elective hip or knee surgery and that there is an association between exaggerated CNS inflammatory response or impaired…
- Trial name
- NCT02759965
- Where
- 2 sites in Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska University Hospital
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Adolescent Idiopathic Scoliosis (AIS)
Perioperative Steroid Dosing on the APR in AIS
The objective of this study is to perform a prospective, randomized controlled trial investigating the clinical usage of perioperative dexamethasone usage on APR activation, postoperative morphine usage, postoperative nausea, and…
- Trial name
- NCT05561725
- Testing
- Dexamethasone postoperative, Standard of Care
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Emory University
Sepsis
Efficacy and Safety of YD0743 Treatment for Sepsis-Associated ARDS
The goal of this clinical trial is to learn if YD0743 works to treat sepsis-associated acute respiratory distress syndrome (ARDS) in adult patients admitted to the Intensive Care Unit.
- Trial name
- NCT07413094
- Testing
- YD0743
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
Sepsis, Septic Shock
Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients
The mortality induced by infections in onco-hematological patients is abnormally high at the acute phase of septic shock. Consequently, it is important to detect the population with a high risk of short term mortality among…
- Conditions
- Sepsis, Septic Shock, Cancer
- Trial name
- PROTEOHSEPS (NCT00930085)
- Testing
- SELDI-TOF MS for plasmatic proteic profile
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Covid19, SARS-CoV Infection
RECOVAC - Long Term Efficacy and Safety of COVID-19 (SARS-CoV-2) Vaccination in Kidney Disease Patients
Rationale: COVID-19 is associated with severely increased morbidity and mortality in patients with chronic kidney disease stage G4-G5 and patients on dialysis or after kidney transplantation.
- Conditions
- Covid19, SARS-CoV Infection, Chronic Kidney Diseases
- Trial name
- LESS CoV-2 (NCT04841785)
- Testing
- mailer-based finger-prick
- Where
- Netherlands
- Volunteers
- 4,868 people
- Sponsor
- University Medical Center Groningen
Surgery, Postoperative Complications
Carbohydrates and Proteins 3h Before Surgery
Prolonged pre-operative fasting increases postoperative hospital stay and current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery.
- Conditions
- Surgery, Postoperative Complications, Inflammation
- Trial name
- NCT01563965
- Testing
- Carbohydrate plus hydrolyzed protein beverage, Preoperative fasting of 8h
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Mato Grosso
Dietary Modification, Healthy
Acute Glycemic and Insulinemic Response of FOSSENCE™
Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity.
- Trial name
- NCT03755232
- Testing
- scFOS, Control
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TATA CHEMICALS LTD
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
The Effect of Deferasirox on Response Rate of Acute Leukemia Patients Not Treated by Standard Chemotherapy Regimens
The purpose of this study is to determine whether deferasirox is effective in the treatment of acute lymphatic leukemia (ALL) and acute Myeloid leukemia (AML).
- Trial name
- NCT02413021
- Testing
- Cytarabine, Deferasirox
- Volunteers
- 40 people
- Sponsor
- Isfahan University of Medical Sciences
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Periodontitis
Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress
This study began enrollment in 2003 with final report completed in October of 2015. This submission is being provided to acquire an NCT number.
- Trial name
- BCU2 (NCT03375372)
- Testing
- Scaling and Root Planing (S&RP)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Response, Acute Phase, Survivorship
Two Schemes Response in Multiple Myeloma
Retrospective study based on medical records of patients with multiple myeloma, eligible for stem cell transplantation, who received, first-line, the VTD or TD combination.
- Trial name
- NCT06284395
- Testing
- Bortezomib
- Where
- Mexico
- Volunteers
- 83 people
- Sponsor
- Hospital General de Mexico
Depression
rTMS Response Trajectories in Depression
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression…
- Trial name
- NCT03348761
- Testing
- rTMS group
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong