Clinical trials: Acute Post-surgical Pain
Acute Postoperative Pain
Erector Spina Plane (ESP) Block in Pediatric Patients
In this study, we aimed to evaluate the erector spina plane (ESP) block method that we used in our clinic with ultrasonography in pediatric cases between 1 month and 2 years of age who underwent laparotomy.
- Trial name
- NCT04875390
- Testing
- Erector spina plane block, local infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
The purpose of this study is to evaluate how tapentadol immediate release (IR) and oxycodone IR treat moderate to severe post-operative pain after elective arthroscopic shoulder surgery.
- Trial name
- NCT00814580
- Testing
- Tapentadol IR, Oxycodone IR
- Volunteers
- 382 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Postoperative Pain, Acute Pain
M-TAPA Block for Analgesia After Open-Heart Surgery
Postoperative pain following open-heart surgery is primarily caused by median sternotomy, although additional contributors include costovertebral joint stress related to sternal retraction and the presence of chest wall and…
- Trial name
- NCT07232979
- Testing
- M TAPA block, Parasternal blocks, Local infiltration
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Symptomatic Irreversible Pulpitis
Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic
This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth.
- Trial name
- NCT07549620
- Testing
- Vital Pulp Therapy, Root Canal Treatment
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Post-op Pain
Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are required over time as the individual becomes tolerant to their effects.
- Trial name
- NCT02123979
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Acute Pain, Postoperative Pain Control
An Efficacy and Safety Study of LTG-001 Following Abdominoplasty
The goal of this clinical trial is to learn if LTG-001 works to treat post-operative / acute pain after an abdominoplasty procedure. It will also learn more information on the safety of LTG-001.
- Trial name
- NCT07102459
- Testing
- Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- Latigo Biotherapeutics
Postoperative Pain, Acute
Transversalis Fascia Plane Block for Iliac Bone Graft in Children
The purpose of this study is to determine which method is more effective in postoperative pain control in children undergoing iliac bone grafting for alveoloplasty under general anesthesia: ultrasound-guided transverse abdominal…
- Trial name
- NCT06403462
- Testing
- transversalis fascial plane block, transversus abdominis plane block
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain Management
Imagined Acupuncture for Postoperative Pain After Spinal Surgery
The goal of this clinical trial is to evaluate whether imagined acupuncture can reduce postoperative acute pain in adult patients undergoing spinal surgery.
- Trial name
- NCT07197710
- Testing
- video-guided acupuncture imagery treatment (VGAIT), Education video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Jingping Wang, MD, Ph.D.
Post Operative Pain, Acute, Post Operative Pain, Chronic
Naldebain for Control of Post-Cesarean Section Pain
Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and…
- Conditions
- Post Operative Pain, Acute, Post Operative Pain, Chronic, Cesarean Section
- Trial name
- NCT05187520
- Testing
- Patient-controlled epidural analgesia (PCEA), Naldebain®
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- E-DA Hospital
Cardiac Disease, Analgesia
Parasternal Block for Cardiac Surgery
This study examine the effect of Parasternal Intercostal Nerve Blocks with local anesthetic on pain control in patients undergoing non-emergent cardiac surgery in a prospective controlled trial.
- Conditions
- Cardiac Disease, Analgesia, Acute Pain, Postoperative Pain
- Trial name
- Parasternal (NCT04319588)
- Testing
- Parasternal Block+ Infiltration with local anesthetic of access to thoracic drainage, Infiltration with local anesthetic of access to thoracic drainage
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Campus Bio-Medico University
Pain, Acute, Pain, Postoperative
Intraoperative Methadone in Children Undergoing Surgery
A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.
- Conditions
- Pain, Acute, Pain, Postoperative, Children, Only
- Trial name
- METACEBO (NCT04680286)
- Testing
- Methadone Hydrochloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Pain, Acute, Knee Arthropathy
Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty
Comparison of continuous adductor canal block to continuous femoral nerve block in patients after total knee arthroplasty. All patients will be anesthetized with spinal anesthesia.
- Conditions
- Pain, Acute, Knee Arthropathy, Postoperative Pain, Mobility Limitation
- Trial name
- NCT03143738
- Testing
- continuous anesthesia of adductor canal, continuous anesthesia of femoral nerve, Spinal anesthesia
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Moderate to Severe Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute moderate to severe…
- Trial name
- NCT01016808
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 5 sites in United States
- Volunteers
- 522 people
- Sponsor
- QRxPharma Inc.
Pain, Postoperative, Ketamine Adverse Reaction
Efficacy of Ketamine in Post Anesthesia Recovery Room
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
- Conditions
- Pain, Postoperative, Ketamine Adverse Reaction, Pain, Refractory, Pain, Intractable
- Trial name
- NCT04701008
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Post Operative Pain, Acute
Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response
The aim of the study is to compare the effect of a repeat moderate dose of glucocorticoids postoperatively after preoperative high dose upon postoperative pain after Total Knee Arthroplasty (TKA) in an High Pain Respondes (HPR)…
- Trial name
- NCT05563155
- Testing
- Dexamethasone 24 mg
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Vejle Hospital
Acute Postoperative Pain
Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy
The goal of this clinical trial is to evaluate the efficacy of intertransverse process block (ITPB) in blunting sympathetic response of sternotomy, achieving perioperative opioid-sparing and improving quality of recovery in adult…
- Trial name
- NCT06926764
- Testing
- Intertransverse process block, Levobupivacaine 0.25%, Sodium Chloride (NaCl) 0.9 %
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Acute Pain
iPACK Block With Dexamethasone For Total Knee Replacement
Comparing the pain control outcomes for patients undergoing total knee arthroplasty (TKA) with either: 1) adductor canal single shot injection plus placebo iPACK injection or 2) adductor canal single shot injection plus…
- Conditions
- Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
- Trial name
- NCT04917055
- Testing
- ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego
Acute Pain
A Study of TRV130 for the Treatment of Pain After Bunionectomy
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain after bunionectomy.
- Trial name
- NCT02100748
- Testing
- TRV130, Morphine
- Where
- 4 sites in United States
- Volunteers
- 333 people
- Sponsor
- Trevena Inc.
Acute Post Operative Pain, Motor Activity
Compartive Study Between Caudal and Perianal Block During Anal Sphincter Sparing Procedures Under General Anesthesia
Anal fistula is an abnormal tract communicating an external opening in the perianal skin with an internal opening in the anal canal. Anal fistula is treated by fistulotomy .
- Trial name
- NCT05557734
- Testing
- caudal block, perianal block
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University