Clinical trials: Acute Post-surgical Pain
Thoracic Anesthesia, Postoperative Pain
Serratus Posterior Superior Intercostal Plane Block Versus Intrathecal Morphine in VATS
This study aims to compare the analgesic effects of the serratus posterior superior intercostal plane block and intrathecal morphine in patients undergoing video-assisted thoracoscopic surgery.
- Conditions
- Thoracic Anesthesia, Postoperative Pain, Video Assisted Thoracic Surgery (VATS)
- Trial name
- NCT07540104
- Testing
- Intrathecal Morphine, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Laparoscopic Cholecystectomy
Bilateral External Oblique İntercostal (EOI) Plane Block in Patients Undergoing Laparoscopic Cholecystectomy.
This study will define the postoperative analgesic effect of ultrasound-guided bilateral External Oblique İntercostal (EOI) Plane Block and compare the control group in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT05536557
- Testing
- Bilateral External Oblique İntercostal (EOI) Plane Block, Standard perioperative and postoperative multimodal analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Karaman Training and Research Hospital
Laparoscopic Inguinal Hernia Repair, Acute Post Operative Pain
Transversalis Fascia Plane Block for Laparoscopic Inguinal Hernia Repair
Transversalis Fascia Plane Block (TFPB) is a trunk block that blocks the T12- L2 spinal nerves by injection of local anesthetic between the transversus abdominis muscle and transversalis fascia on the lateral abdominal wall.
- Trial name
- TFPB (NCT06778629)
- Testing
- Transversalis Fascia Plane Block, Post Operative Pain Management, Port Site Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Postoperative Cognitive Dysfunction, Postoperative Pain, Acute
Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD
This study will examine the effect of intraoperative sedation with midazolam, propofol and dexemdetomidine on the occurrence of postoperative cognitive impairment in patients undergoing surgical treatment of pertrochanteric…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric Fracture
- Trial name
- ProDex-POCD (NCT05398757)
- Testing
- Mini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS)
- Where
- Croatia
- Sponsor
- Osijek University Hospital
Postoperative Pain, Analgesia
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy
Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure…
- Conditions
- Postoperative Pain, Analgesia, Supratentorial Brain Tumor
- Trial name
- NCT06406829
- Testing
- Dexmedetomidine, Normal saline, Local analgesic techniques
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative, Length of Stay
ICNBs for Post-op Pain in Breast Surgery
The authors will conduct this study to analyze the effectiveness of peri-operative intercostal nerve blocks (ICNBs) in reducing acute postoperative pain after reconstructive breast surgery and mammoplasty and how it affects the…
- Trial name
- NCT04606836
- Testing
- Bupivacaine Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Anesthesia, Analgesia
Preoperative Dexamethasone to Improve Quality of Recovery After Laparoscopic Bariatric Surgery
In the obese patient, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Analgesia, Acute Pain
- Trial name
- NCT05752734
- Testing
- Group D, Group C
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Acute Pain, Chronic Postsurgical Pain
The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery
This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.
- Trial name
- NCT03847363
- Testing
- epidural anesthesia, nerve block
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Zhongshan Hospital
Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
Comparison of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block
Breast cancer is the most common malignancy in women. Modified radical mastectomy, a surgical procedure in the treatment of breast cancer, is one of the standard treatments.
- Conditions
- Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block, Acute Pain, Postoperative Pain
- Trial name
- NCT06407037
- Testing
- Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Postoperative Pain, Acute
The Effect of Preemptive Pregabalin on Postoperative Pain and Respiratory Dynamics in Robotic Prostatectomy Operation.
The study aimed to investigate the impact of preemptive pregabalin on the postoperative pain severity and the requirement of analgesic drugs in patients undergoing robotic radical prostatectomy surgery as primary outcome.
- Trial name
- NCT06170359
- Testing
- robotic surgery under general anaesthesia
- Volunteers
- 90 people
- Sponsor
- Umraniye Education and Research Hospital
Acute Pain, Analgesia
The Relationship Of The Surgical Pleth Index Values With Postoperative Pain Score And Analgesia Consumption
Postoperative pain management has an important role in anesthesia practice. In order to ensure postoperative patient comfort, postoperative rehabilitation should start early and be managed effectively1.
- Trial name
- NCT05147714
- Testing
- Surgical Pleth Index (SPI)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Post Operative Pain, Acute
Articaine Plus Dexmedetomidine in Supraclavicular Block
Articaine has emerged as a local anesthetic (LA) that produces sensory and motor blockade shorter than bupivacaine and lower in neurotoxicity than lidocaine.
- Trial name
- NCT06423859
- Testing
- Articaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Benha University
Abdominoplasty
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in the Management of Acute Postoperative Pain
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in patients after mini-abdominoplasty
- Trial name
- NCT04182880
- Testing
- CPL-01
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cali Pharmaceuticals LLC
Postoperative Pain, Acute
Postoperative Pain After Implementation of Standardized Pain Therapy Management in Orthopaedic Patients
The aim of this study is to examine the impact of implementing a standardized pain therapy protocol and their components on postoperative pain trajectories and postoperative outcomes such as increased opioid consumption and to…
- Trial name
- PAIN (NCT06363227)
- Testing
- Standardized pain management
- Volunteers
- 12,000 people
- Sponsor
- Schulthess Klinik
Pain
A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery
Primary Objective： To explore the analgesic efficacy of YZJ-4729 compared with placebo in patients with acute postoperative pain following abdominal surgery.
- Trial name
- NCT06680466
- Testing
- YZJ-4729, morphine
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Acute Pain, Perioperative/Postoperative Complications
Effect of Aromatherapy on Postoperative Pain: Randomized Clinical Trial
Introduction: Pain is one of the main complications in the immediate postoperative period that can harm the patient and can be managed through pharmacological and non-pharmacological methods.
- Conditions
- Acute Pain, Perioperative/Postoperative Complications, CAM, Nurse's Role
- Trial name
- NCT06294769
- Testing
- essencial oil of lavandula angustifolia, grape seed vegetable oil
- Where
- Brazil
- Volunteers
- 138 people
- Sponsor
- University of Sao Paulo
Post Operative Pain
Assessment of Post-Operative Pain After Using Cryotherapy and Dexamethasone
Evaluation and comparing the effect of cryotherapy and dexamethasone on inflammatory mediators and post-operative pain in symptomatic irreversible pulpitis with acute apical periodontitis.
- Trial name
- NCT07738302
- Testing
- cold NaOCl , dexamethasone, NaOCl, dexamethasone, cold NaOCl and cold saline
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Pain, Postoperative
Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgeries (VATS) include severe postoperative acute pain which is also a predictor of chronic pain.
- Trial name
- VATS (NCT02302586)
- Testing
- Thoracic paravertebral block (TPVB), Patient Controlled Analgesia (IV PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Juvenile; Scoliosis, Scoliosis Idiopathic
Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery
This is a randomized controlled trial to test effectiveness of the SurgeryPal intervention vs. education control to improve acute and chronic pain and health outcomes in youth undergoing major musculoskeletal surgery.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgeryPal (NCT04637802)
- Testing
- CBT (SurgeryPal), Education
- Where
- United States
- Volunteers
- 433 people
- Sponsor
- Seattle Children's Hospital
Analgesia, Pain, Acute
A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block
This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs).
- Conditions
- Analgesia, Pain, Acute, Upper Extremity Surgery, Nerve Block
- Trial name
- NCT07249827
- Testing
- dexmedetomidine (perineural) 0.67 mcg/kg, dexmedetomidine (perineural) 1 mcg/kg, dexmedetomidine (perineural) 1.33 mcg/kg
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre