Clinical trials: Acute Post-surgical Pain
Anesthetics, Local Anesthetics
Lidocaine Versus ESP - After Bariatric Surgery
The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes.
- Trial name
- NCT05700214
- Testing
- Ropivacaine injection, Lidocaine IV
- Where
- Poland
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Postoperative Pain
Impact of Gender on Perceived Postoperative Pain
Postoperative pain is a common problem after surgical procedures with many patients afflicted worldwide. Fundamental challenges are the complexity of measuring pain appropriately, and the many associated possible confounders.
- Trial name
- G-PAIN (NCT03968497)
- Testing
- Postoperative pain assessment with female investigator, Postoperative pain assessment with male investigator
- Where
- Sweden
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Lund University
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Cesarean Delivery, Postoperative Pain
The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery
Working Title The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery Study Description This study aims to evaluate the effects of intrathecal…
- Conditions
- Cesarean Delivery, Postoperative Pain, Cytokine Levels, Chronic Pain, Postoperative
- Trial name
- NCT06684015
- Testing
- İNTRATECHAL MORPHİNE GROUP, Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Ankara University
Postoperative Pain
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
The purpose of this study is to evaluate how tapentadol immediate release (IR) and oxycodone IR treat moderate to severe post-operative pain after elective arthroscopic shoulder surgery.
- Trial name
- NCT00814580
- Testing
- Tapentadol IR, Oxycodone IR
- Volunteers
- 382 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Regional Anesthesia, Postoperative Pain, Acute
Caudal Block and Transversus Abdominis Plane Block in Pediatric Inguinal Hernia Repair
Pediatric inguinal hernia repair (IHR) candidates experiences ordinarily mild to moderate pain, rarely severe pain in the postoperative period.
- Trial name
- NCT05286190
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pain
A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery
Primary Objective： To explore the analgesic efficacy of YZJ-4729 compared with placebo in patients with acute postoperative pain following abdominal surgery.
- Trial name
- NCT06680466
- Testing
- YZJ-4729, morphine
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Post Operative Pain, Acute
Comparison of Needlescopic vs. Conventional Laparoscopic Adrenalectomy for Tumor Less Than 4 cm
The investigator conduct a randomized clinical trial for the needlescopic and conventional laparoscopic adrenalectomy to assess whether mini laparoscopic adrenalectomy is better than conventional laparoscopic adrenalectomy in…
- Trial name
- NCT05675124
- Testing
- Needlescopic laparoscopic adrenalectomy, conventional laparoscopic adrenalectomy
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- National Taiwan University Hospital
Postoperative Pain, Acute Pain
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery
This randomized clinical trial will compare suzetrigine with standard analgesia for postoperative pain management after skin cancer surgery.
- Conditions
- Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy
- Trial name
- NCT07843134
- Testing
- Suzetrigine, Acetaminophen Plus Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Minnesota
Pain, Postoperative, Acute Pain
Comparison of Postoperative Pain With or Without Apical Patency Technique in Asymptomatic Necrotic Teeth
Apical patency is a technique in which the apical portion of the canal is maintained free of soft tissue remnants and dentinal debris by recapitulation with a small #10k file through the apical foramen.
- Trial name
- NCT05574088
- Testing
- Apical patency with file
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Prime Foundation
Postoperative Pain, Acute
The Effect of Local Anesthesia on Postopanalgesia in Patients Using Head Holder
Aim:The head holder used in neurosurgery operations causes pain in patients both peroperatively and postoperatively.Severe pain-related hemodynamic changes are seen in these participants.In our study, the investigators compared…
- Trial name
- NCT07629713
- Testing
- lidocaine was administered subcutaneously at 0.5% concentration., lidocaine was administered subcutaneously at 1% concentration.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Kocaeli University
Postoperative Pain, Acute
Effect of Sufentanil on the Postoperative Pain
This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
- Trial name
- NCT06260046
- Testing
- Sufentanil, Remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Chronic Pain, Acute Pain
Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs
The aim of this study is to evaluate the impact of intravenous lidocaine on acute and chronic post surgical pain on patients undergoing video assisted thoracoscopic surgery(VATS).
- Conditions
- Chronic Pain, Acute Pain, Neuralgia
- Trial name
- NCT02862769
- Testing
- Lidocaine, Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Pain
The Ketamine for Acute Postoperative Analgesia (KAPA) Trial
Postoperative pain remains an important challenge for both patients and clinicians. Despite advances in pain management techniques, many patients continue to describe their pain as moderate to severe immediately after surgery.
- Trial name
- KAPA (NCT04646694)
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Acute Post Operative Pain, Laparotomy
PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose
Pain control after surgery is a crucial component of postoperative recovery. Thus, in open abdominal surgery, the use of TEA (Thoracic epidural analgesia) has become a gold standard.
- Conditions
- Acute Post Operative Pain, Laparotomy, Epidural Analgesia
- Trial name
- PIBDOSE (NCT05534945)
- Testing
- Programmed intermittent epidural bolus 5 ml, Programmed intermittent epidural bolus 6 ml, Programmed intermittent epidural bolus 7 ml
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Post Operative Pain
Relationship Between Acute Phase Markers and Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study
Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain. The aim of the study is to show a possible correlation between pain and acute phase proteins in order to…
- Trial name
- NCT06375057
- Testing
- laparoscopic cholecystectomy
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- University of Roma La Sapienza
Postoperative Pain
Efficacy and Safety of Q8003 in the Management of Post-bunionectomy Pain
This study will explore the efficacy and safety of a fixed dose combination of morphine and oxycodone for management of acute postoperative pain.
- Trial name
- NCT00560183
- Testing
- Q8003 (morphine sulfate and oxycodone hydrochloride)
- Where
- 6 sites in United States
- Volunteers
- 256 people
- Sponsor
- QRxPharma Inc.
Pain, Postoperative
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The objective of this study is to evaluate the safety and clinical utility of the active, SSEC fentanyl 40 micrograms (mcg) for the management of acute, postoperative pain in pediatric participants.
- Trial name
- NCT02395653
- Testing
- fentanyl
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- The Medicines Company
Post-operative Pain, Acute
To Compare the Skin Incision Made by the Electrocautery and Scalpel in Inguinal Hernia Repair
The Groin hernia repair is a commonly performed general surgery procedure in both adults and children with inguinal hernias constituting more than 95% of all groin hernia repairs.
- Trial name
- NCT05666973
- Testing
- Open Mesh Hernioplasty
- Volunteers
- 60 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Appendectomy, Pain, Postoperative
Comparison of Outcomes After Laparoscopic Versus Open Appendectomy in Acute Appendicitis
A comparison study was performed between laparoscopic appendectomy and open appendectomy in acute setting in tertiary hospital to access the outcome of postoperative pain and hospital stay.
- Conditions
- Appendectomy, Pain, Postoperative, Length of Stay
- Trial name
- NCT03947372
- Testing
- Appendectomy
- Where
- Pakistan
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Services Hospital, Lahore