Clinical trials: Acute Post-surgical Pain
Orthopaedic Surgery
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery
The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain.
- Trial name
- NCT00822549
- Testing
- intravenous morphine titration
- Where
- France
- Volunteers
- 438 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Delirium
Longitudinal Cohort Study - for the Treatment of Acute Postoperative Pain and Postoperative Delirium, Postoperative Cognitive Dysfunctions, and Chronic Pain.
Adequate pain therapy is important aspect of perioperative care. Sequelae of inadequate pain management are patient dissatisfaction, post-operative nausea and vomiting (PONV), inadequate nutrition, lack of mobilization, and an…
- Conditions
- Pain, Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT03133858
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Appendicitis Acute, Pediatrics
TAP Block Versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Appendicectomy in Children
When performing laparoscopic appendectomy in children, regional anesthetic techniques are rou-tinely used concomitantly with general anesthesia.
- Conditions
- Appendicitis Acute, Pediatrics, Analgesia
- Trial name
- PABLO (NCT04969133)
- Testing
- Levobupivacaine Hydrochloride 2.5 MG/ML
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Bunionectomy, Orthopedic Surgery
Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy
To determine whether a single dose of intravenous lornoxicam is superior to intravenous placebo for management of post-operative pain in patients who have surgical removal of a bunion on the lower extremity.
- Trial name
- NCT00293631
- Testing
- Lornoxicam 8 mg, Lornoxicam 16 mg, Ketorolac 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- POZEN
Postoperative Nausea and Vomiting, Acute Postoperative Pain
Influence of Hypnoacupuncture on Early Perioperative Recovery
Perioperative stress is associated with various influences before and after surgery. Instead of benzodiazepines, patients can be calmed by non-pharmacological methods.
- Trial name
- NCT05068037
- Testing
- ACUPUNCTURE, ANTIEMETICS, NOTHING
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Rebound Pain, Sciatic Nerve Block
Influence of Sensory Block Duration on Rebound Pain After Outpatient Foot Surgery Under Popliteal Sciatic Nerve Block.
Rebound pain after surgeries under peripheral nerve block is defined as the appearance of severe acute postoperative pain after regression of the sensory block.
- Conditions
- Rebound Pain, Sciatic Nerve Block, Foot Surgery, Outpatient Surgery
- Trial name
- NCT06309381
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Hospital Universitario Doctor Peset
Pain, Acute Pain
Millimeter Wave Therapy (MWT) for Analgesia After Total Knee Replacement
The aim of the study was to test whether the exposure to electromagnetic millimeter waves - Millimeter Wave Therapy (MWT) is effective for relief of acute postoperative pain in patients after elective unilateral total knee…
- Trial name
- NCT00233831
- Testing
- Generator of electromagnetic millimeter waves
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Medicine Greifswald
Anterior Cruciate Ligament Rupture, Acute Pain
Femoral Triangle + IPACK Blocks for ACL Reconstruction Analgesia
An adequate balance between analgesia and motor function is an essential requirement to facilitate functional recovery and early discharge after anterior cruciate ligament (ACL) reconstruction surgery. Proximal nerve blocks (i.e.
- Conditions
- Anterior Cruciate Ligament Rupture, Acute Pain, Pain, Postoperative, Knee Injuries
- Trial name
- NCT05068063
- Testing
- Bupivacaine Injection, normal Saline
- Where
- 2 sites in Chile
- Volunteers
- 48 people
- Sponsor
- University of Chile
Post Operative Pain, Acute
Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy
Adeno-tonsillectomy is one of the most common surgeries in children. The most common complication associated is postoperative pain.
- Trial name
- NCT05565664
- Testing
- Ketamine hydrochloride, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Pain, Acute, Postoperative Pain
Use of Dexamethasone Via Two Different Methods in PENG Block
Hip fractures are morbid conditions, especially in elderly patients, and their treatment is usually surgical. Pericapsular nerve group block targets the hip capsule.
- Conditions
- Pain, Acute, Postoperative Pain, Hip Fractures
- Trial name
- NCT06242028
- Testing
- Group P, Group S
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ondokuz Mayıs University
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Moderate to Severe Acute Postoperative Pain
Evaluate the Safety and Efficacy of HL-1186 Tablet for Moderate to Severe Acute Pain After Surgery
This is a multiple-center, randomized, double-blind, placebo-controlled study design evaluating the safety, efficacy, and pharmacokinetics (PK) parameter of HL-1186 tablet for moderate to severe acute pain after surgery.
- Trial name
- NCT07147049
- Testing
- HL-1186
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
Other Acute Postoperative Pain, Prolonged Endotracheal Intubation
Pharmacokinetics, Safety, and Efficacy of Intravenous Dosing of Buprenorphine in Pediatric Patients Who Require Opioid Analgesia for Acute Moderate to Severe Pain
The purpose of this study is to characterize the safety, pharmacokinetics (PK), and efficacy of intravenous (IV) buprenorphine in pediatric patients.
- Trial name
- NCT01324544
- Testing
- Buprenorphine IV
- Sponsor
- Purdue Pharma LP
Pain
From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy
Chronic Pain is a wellknown complication after cholecystectomy. Intensity of the pain in the first week after the operation is a predictive factor for the development of chronic pain, but it is unknown whether the risk is more…
- Trial name
- FACTS1 (NCT01553253)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Endometriosis, Postoperative Pain
Intraoperative Clonidine for Postoperative Pain Management in Patients Undergoing Surgical Treatment for Endometriosis
The role of a single dose of intraoperative clonidine on postoperative opioid requirements, pain intensity and opioid-related side effects in patients undergoing surgical treatment for endometriosis remains scarcely explored.
- Conditions
- Endometriosis, Postoperative Pain, Pain, Acute, Pain, Acute Postoperative
- Trial name
- CLONIPAIN (NCT05560230)
- Testing
- Clonidine, Isotonic saline
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Osteoarthritis, Postoperative Pain
Acute Pain Genomic Study
In preparation for future large-scale genome wide association studies, reliable methods must be developed for measuring perceived pain and for estimating the effects of potentially confounding factors such as appropriate…
- Trial name
- NCT01557751
- Testing
- Whole blood for genotyping
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pittsburgh
Surgery, Pain
Peri-operative Psychology and Post-operative Pain Study
The experience of pain is common among hospital inpatients. Orthopaedic surgery often results in significant pain, which may last for some time.
- Conditions
- Surgery, Pain, Anxiety, Depression
- Trial name
- 4P (NCT02004431)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University Hospital Plymouth NHS Trust
Acute Postoperative Pain in Urological Surgery, Pain Management in Postoperative Care (Including Opioid-Sparing Approaches)
Nudging to Promote the Use of Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief
This study aims to increase the use of transcutaneous electrical nerve stimulation (TENS) for acute postoperative pain relief. TENS, a non-pharmacological treatment using electrical impulses, can enhance pain relief, reduce…
- Trial name
- Nudging pain (NCT06696430)
- Testing
- Educational Intervention on TENS Usage, Nudging Intervention to Promote TENS Usage
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Pether Jildenstal
Acute Pain
Comparison Between Percutaneous Femoral Nerve Neuromodulation Associated With Femoral Nerve Block and Standard Clinical Practice in Patients Undergoing Knee Arthroplasty.
The goal of this clinical trial is to compare the maximum isometric contraction force differential of the quadriceps in the postoperative period after the use of a peripheral nerve neuromodulation program in patients undergoing…
- Trial name
- NEPFAR (NCT05971095)
- Testing
- Percutaneous neuromodulation using the EPTE® Bipolar System device
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital General Universitario de Valencia
Pain, Postoperative
Safety and Efficacy of Repeated Doses of PMI-150 (Intranasal Ketamine) in Acute Post-operative Pain Following Orthopedic Surgery
The purpose of this research study is to evaluate the safety and analgesic efficacy of PMI-150 (intranasal ketamine) compared to placebo in patients with acute post-operative pain following orthopedic trauma, injury, or surgery.
- Trial name
- NCT00709436
- Testing
- PMI-150 (intranasal ketamine)
- Where
- 16 sites in United States
- Volunteers
- 250 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer