Clinical trials: Acute Post-surgical Pain
Post Operative Pain, Acute
Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment
This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment.
- Trial name
- NaOCl-RCT (NCT07618182)
- Testing
- Sodium Hypochlorite Irrigation
- Volunteers
- 116 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Pain, Orthognathic Surgery
Effect of Nefopam on Acute Postoperative Pain in Patients Undergoing Orthognathic Surgery
The aim of this study is to determine the analgesic effect of perioperative nefopam on acute pain in patient undergoing orthognathic surgery.
- Trial name
- NCT01461031
- Testing
- nefopam, normal saline (control)
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Acute Pain
Effect of Rectus Sheath Block on Diaphragmatic Function After Elective Upper Abdominal Surgery
This study will be undertaken to investigate the respiratory and analgesic effects of ultrasound guided rectus sheath block analgesia after elective abdominal surgery with midline incision.
- Trial name
- Rectus (NCT03725527)
- Testing
- Rectus Sheath Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Rebound Pain, Sciatic Nerve Block
Influence of Sensory Block Duration on Rebound Pain After Outpatient Foot Surgery Under Popliteal Sciatic Nerve Block.
Rebound pain after surgeries under peripheral nerve block is defined as the appearance of severe acute postoperative pain after regression of the sensory block.
- Conditions
- Rebound Pain, Sciatic Nerve Block, Foot Surgery, Outpatient Surgery
- Trial name
- NCT06309381
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Hospital Universitario Doctor Peset
Postoperative Pain
Efficacy and Safety of Q8003 in the Management of Post-bunionectomy Pain
This study will explore the efficacy and safety of a fixed dose combination of morphine and oxycodone for management of acute postoperative pain.
- Trial name
- NCT00560183
- Testing
- Q8003 (morphine sulfate and oxycodone hydrochloride)
- Where
- 6 sites in United States
- Volunteers
- 256 people
- Sponsor
- QRxPharma Inc.
Acute Postoperative Pain, Thoracic Surgical Procedures
Transcutaneous Electrical Nerve Stimulation for Acute Postoperative Pain After Video-Assisted Thoracoscopic Surgery
This randomized, double-blind, sham-controlled study aims to evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on acute postoperative pain, sleep quality, and quality of life in patients undergoing…
- Trial name
- NCT07732764
- Testing
- Active TENS
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Fooyin University
Pain, Postoperative
Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
Multiple-center, multiple-dose, randomized, double-blind, six-arm, active- and placebo-controlled study in patients with moderate to severe post-surgical pain from elective orthopedic surgery with safety observed for a total of…
- Trial name
- NCT00390039
- Testing
- Intranasal Morphine, IV morphine
- Where
- 7 sites in United States
- Volunteers
- 256 people
- Sponsor
- Javelin Pharmaceuticals
Pain, Postoperative / Acute Pain
Opiranserin Injections PCA Regimens for Postoperative Pain
The purpose of this phase 2 study is to evaluate the efficacy and safety of PCA regimen of opiranserin (VVZ-149) injections in patients undergoing laparoscopic colectomy.
- Trial name
- NCT07821307
- Testing
- VVZ-149 Injections, Fentanyl
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Appendicitis
Ultrasound-guided Abdominal Wall Nerve Blockade in Laparoscopic Surgery for Acute Appendicitis.
Acute appendicitis is a common disease and usually occurs within the ages of 10-30 years old." Ten percent of the population will get this disease during a lifetime." At Bispebjerg hospital it is one of the most common acute…
- Trial name
- BD-TAP APP (NCT01825863)
- Testing
- Ropivacaine, Saline 9%
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Bispebjerg Hospital
Acute Post Operative Pain
Various Strategies to Reduce Acute Post Hemorrhoidectomy Pain: A Comparative Study
Since post hemorrhoidectomy pain is a severe and common post operative symptom so there is a need to find a suitable method for reducing this pain, up to our knowledge, this the first study in ZUH to compare between ketrolac…
- Trial name
- NCT06307106
- Testing
- ketorolac and light marcaine, light marcaine, Corticosteroids injection
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Zagazig University
Other Acute Postoperative Pain, Pain, Postoperative
Effects of Local Anaesthetic Infusion Rates on Nerve Block Duration
This trial is a part of the project: 'A novel technique for reliable, precise and safe postoperative pain management' (project no. 65-2014-3).
- Conditions
- Other Acute Postoperative Pain, Pain, Postoperative, Anaesthesia
- Trial name
- NCT02801799
- Testing
- Varying infusion rates of Ropivacaine 0.2%
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Postoperative Pain, Chronic Postsurgical Pain
Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy
This study evaluated whether bilateral erector spinae plane block (ESPB) performed before abdominal hysterectomy could reduce postoperative pain and the development of chronic and neuropathic pain.
- Trial name
- NCT07830706
- Testing
- Bupivacaine, Standard Perioperative Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Necmettin Erbakan University
Acute Postoperative Pain, Chronic Post Operative Pain
Clinical Prediction of Post-surgical Pain
This study aims to externally validate two clinical prediction models for moderate-to-severe acute post-surgical pain and chronic post-surgical pain.
- Trial name
- NCT06661642
- Where
- 2 sites in Denmark
- Volunteers
- 748 people
- Sponsor
- Aarhus University Hospital
Heart Valve Diseases, Postoperative Pain, Acute
ESP Block in Robotic Cardiac Surgery
Patients undergoing cardiac robotic surgery will receive different pain management after being randomized in 2 groups. Control group will receive standard of care pain management with acetaminophen and morphine in PCA pump, and…
- Conditions
- Heart Valve Diseases, Postoperative Pain, Acute, Analgesia
- Trial name
- NCT05702151
- Testing
- ESP Block, Morphine injection
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Cholelithiasis (Without Cholecystitis), Cholecystitis, Acute
Comparison of Gallbladder Extraction Via Subxiphoid vs Infraumbilical Port in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is the standard surgical treatment for symptomatic gallstone disease due to its advantages in reducing postoperative pain and recovery times.
- Trial name
- NCT07672145
- Testing
- Subxiphoid Gallbladder Retrieval, Infraumbilical Gallbladder Extraction
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- King Edward Medical University
Postoperative Pain
Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery
The goal of this clinical trial] is to further explore the effectiveness and safety of oxelidine in the treatment of moderate to severe acute pain after orthopedic surgery.
- Trial name
- NCT06320041
- Testing
- Low dose oxelidine group, High dose oxelidine group, Hydromorphone group
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pain, Postoperative, Pain, Acute
Latinx Children and Surgery
Over 60 million persons in the United States (US) identify themselves as Latinx and 25.6% are children under the age of 16. Surgical disparities for adults and children have been identified as a major problem in the US and can be…
- Trial name
- NCT06020677
- Testing
- L-WebTIPS
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Chronic Pain, Anaesthesia
Comprehensive Pain Programme to Determine Mechanism of Transition of Acute to Chronic Postsurgical Pain
To determine whether central sensitization is a mechanism of CPSP (chronic postsurgical pain) in women who will develop CPSP compared to women with no CPSP after hysterectomy.
- Conditions
- Chronic Pain, Anaesthesia, Genetics Predisposition
- Trial name
- TAHP (NCT02025153)
- Testing
- pain testing
- Where
- Singapore
- Volunteers
- 216 people
- Sponsor
- KK Women's and Children's Hospital