Clinical trials: Acute Post-surgical Pain
Chronic Pain, Acute Pain
Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs
The aim of this study is to evaluate the impact of intravenous lidocaine on acute and chronic post surgical pain on patients undergoing video assisted thoracoscopic surgery(VATS).
- Conditions
- Chronic Pain, Acute Pain, Neuralgia
- Trial name
- NCT02862769
- Testing
- Lidocaine, Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Pain, Postoperative, Anesthesia
Anaesthesiological Involvement in Postoperative Pain Treatment
This study aims to investigate the current organization and management of postoperative pain in Denmark, especially for invasive pain treatment modalities (epidural infusions, PCA and regional blocks), in a national survey…
- Conditions
- Pain, Postoperative, Anesthesia, Epidural Analgesia, Acute Pain
- Trial name
- NCT03496194
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Postoperative Pain, Acute
Analgesic and Anti-inflamatory Effect of Vit. B
Vitamin C, also known as ascorbic acid, is a potent reducing agent and antioxidant that plays a crucial role in various metabolic processes.Vitamin B complex, a group of eight essential B vitamins, plays a crucial role in…
- Trial name
- vit B/vit C (NCT06857734)
- Testing
- Vitamin B Complex, vitamin C
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benha University
Phantom Limb Pain, Postoperative Pain
Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Limb loss is frequently associated with postamputation pain that can be challenging to treat and often involves opioids. Advances in the field of neuromodulation has led to development of an intentionally reversible percutaneous…
- Conditions
- Phantom Limb Pain, Postoperative Pain, Neuroma, Acute Pain
- Trial name
- NCT03484429
- Testing
- Peripheral nerve stimulation, Standard Medical Therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Pain, Acute, Pain, Postoperative
The Impact of Esmolol Administration on Postoperative Recovery
The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain
- Conditions
- Pain, Acute, Pain, Postoperative, Pain, Chronic Post-Surgical, Esmolol
- Trial name
- esmolol (NCT05567822)
- Testing
- Esmolol Hydrochloride, normal saline
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aretaieion University Hospital
Pain
A Study of TRV130 for the Treatment of Pain After Abdominoplasty
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain following abdominoplasty.
- Trial name
- NCT02335294
- Testing
- TRV130, Morphine
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Trevena Inc.
Acute Post Operative Pain
Improvement in Postoperative Pain Outcomes
This is an observational study project aims at improving postoperative pain outcomes by evaluating the current status of postoperative pain managements in the institution.
- Trial name
- NCT05624502
- Where
- Saudi Arabia
- Volunteers
- 1,000 people
- Sponsor
- King Saud University
Acute Postoperative Pain, Video-assisted Thoracic Surgery
Effectiveness and Safety of Adjuvant Software Based on Virtual Reality for Post-thoracoscopic Surgery Pain
A randomized controlled, prospective, multicenter, open label, superiority trial aims to evaluate the effectiveness and safety of adjuvant software based on virtual reality for post-thoracoscopic surgery pain.
- Conditions
- Acute Postoperative Pain, Video-assisted Thoracic Surgery, Virtual Reality
- Trial name
- VR-TSP (NCT06574451)
- Testing
- VR-assisted postoperative analgesia
- Where
- 4 sites in China
- Volunteers
- 215 people
- Sponsor
- Guangdong Provincial People's Hospital
Postoperative Pain, Inguinal Hernia
The Effect of Erector Spinae Plane Block on Quality of Recovery and Postoperative Analgesia After Inguinal Hernia Repair
Inguinal hernia repair (IHR) is one of the most commonly performed operations in general surgery practice. Different pharmacological approaches and interfascial plane blocks are used to control postoperative pain.
- Conditions
- Postoperative Pain, Inguinal Hernia, Acute Pain
- Trial name
- NCT04300153
- Testing
- ESP Block, Global Quality of Recovery-15 score, Standard Pain Followup and Monitorization
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Başak Altıparmak
Postoperative Pain Management, Lumbar Discectomy
Quadro-Iliac Plane Block Versus Wound Infiltration for Postoperative Pain After Single-Level Lumbar Discectomy
This prospective observational study aims to compare the effects of the Quadro-Iliac Plane Block (QIPB) and wound infiltration (WI) on postoperative acute pain in adult patients undergoing elective single-level lumbar discectomy.
- Conditions
- Postoperative Pain Management, Lumbar Discectomy, Regional Anaesthesia
- Trial name
- NCT07237945
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Elif Sarikaya Ozel
Root Canal Treatment, Irreversible Acute Pulpitis
Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers
To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers
- Trial name
- NCT07574801
- Testing
- root canal treatment
- Volunteers
- 30 people
- Sponsor
- Cairo University
Oxycodone, Thoracoscopic Lobectomy
Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment
The goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy.
- Conditions
- Oxycodone, Thoracoscopic Lobectomy, Acute Postoperative Pain
- Trial name
- NCT06534801
- Testing
- Oxycodone will be administered intravenously in the group 1
- Volunteers
- 60 people
- Sponsor
- Jianbo Wu
Endometriosis, Postoperative Pain
Intraoperative Clonidine for Postoperative Pain Management in Patients Undergoing Surgical Treatment for Endometriosis
The role of a single dose of intraoperative clonidine on postoperative opioid requirements, pain intensity and opioid-related side effects in patients undergoing surgical treatment for endometriosis remains scarcely explored.
- Conditions
- Endometriosis, Postoperative Pain, Pain, Acute, Pain, Acute Postoperative
- Trial name
- CLONIPAIN (NCT05560230)
- Testing
- Clonidine, Isotonic saline
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Kidney Diseases, Post Operative Pain
Methadone Pharmacokinetics in End-stage Renal Disease
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute…
- Conditions
- Chronic Kidney Diseases, Post Operative Pain, Pain, Acute
- Trial name
- MCKD (NCT06056245)
- Testing
- Preoperative step, Intraoperative, Post-operative
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Opioid Use, Pain, Acute
Pre-post Erector Spine Plane Block-spinal Surgery
Spinal surgery patients generally have chronic pain in the preoperative period and are exposed to widespread and severe acute pain postoperatively.
- Trial name
- pre-post-esp (NCT06215053)
- Testing
- erector spine plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Aydin Adnan Menderes University
Pain
The Effect of Pregabalin and Dexamethasone on Acute and Chronic Pain After Lumbar Spinal Surgery
Multimodal analgesia may be important for optimal postoperative pain treatment and facilitation of early mobilization and recovery.
- Trial name
- NCT01168531
- Testing
- Pregabalin, dexamethasone
- Where
- South Korea
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Postoperative Pain, Postoperative Pain, Acute
Incidence of Chronic Pain After Thoracotomy
Thoracotomy is frequently performed in thoracic surgery. It is widely accepted that thoracotomy causes severe acute pain. Many factors such as postoperative analgesia treatment plan, operation time, number of chest tubes, and…
- Conditions
- Postoperative Pain, Postoperative Pain, Acute, Postoperative Pain, Chronic, Thoracotomy
- Trial name
- NCT05177575
- Testing
- Thoracotomy application
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Pain, Nausea
Evaluation of the Effect of the LI4 Cold Application
It is an experimental study conducted to evaluate the effectiveness of cold application to the LI4 point of the hand to reduce/eliminate pain, nausea and anxiety in postoperative patients.
- Conditions
- Pain, Nausea, Anxiety
- Trial name
- LI4 (NCT06357429)
- Testing
- Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Saglik Bilimleri Universitesi
Tonsillectomy, Pharyngoplasty
Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine can lower how much opioid pain medicine adults need after tonsil surgery (tonsillectomy) or a similar throat surgery.
- Conditions
- Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid
- Trial name
- STOP (NCT07821931)
- Testing
- Suzetrigine, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stanford University