Clinical trials: Acute Post-surgical Pain
Nausea, Vomiting
Predictive Factors for Postoperative Pain, Nausea and Vomiting in Oncological Patients
1809 patients were evaluated in postoperative period. They were asked about nausea, vomiting, retching and pain in the first postoperative 24 hours
- Conditions
- Nausea, Vomiting, Pain, Postoperative
- Trial name
- PONV (NCT04889534)
- Testing
- Analgesia
- Where
- Brazil
- Volunteers
- 1,500 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Other Acute Postoperative Pain
Oxycodone Hydrochloride Injection in the Postoperative Pain Relieving Treatment
To determine the efficacy and safety of oxycodone i.v. patient-controlled analgesia (PCA) in the pain relieving treatment during 48h postoperative period, by comparing with morphine i.v. PCA.
- Trial name
- NCT01304134
- Testing
- Oxycodone, Morphine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Postoperative Pain
Propofol Versus Sevoflurane on Acute Postoperative Pain
This study was performed to compare the acute postoperative pain intensity and opioid consumption after total shoulder arthroplasty between propofol-remifentanil and sevoflurane-remifentanil anesthesia.
- Trial name
- NCT04333992
- Testing
- propofol and remifentanil, sevoflurane and remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yeungnam University College of Medicine
Pain, Postoperative, Orthopedic Procedures
A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain
The purpose of this small study was to investigate the safety and effectiveness of OROS hydromorphone HCI for the treatment of short-term, moderate to severe postoperative pain following total knee replacement surgery.
- Conditions
- Pain, Postoperative, Orthopedic Procedures, Analgesia
- Trial name
- NCT00411307
- Testing
- OROS hydromorphone HCI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alza Corporation, DE, USA
Pain, Postoperative
Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulps
Aim to compare acute pain rate after single-visit ortwo-visits treatment of teeth with necrotic pulp and apical periodontitis .90 teeth with a diagnosis of pulp necrosis and apical radiolucency at the apex.Working length was…
- Trial name
- Acute pain (NCT04115904)
- Testing
- Ibuprofen for post operative pain
- Where
- 4 sites in Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Postoperative Pain, Spinal Fusion
Sufentanil NanoTab PCA System/15 mcg for Acute Post-Operative Pain in Vertebral Surgery: A Preliminary Investigation
The Zalviso® Sufentanil Sublingual Tablet System (SSTS) (Grünenthal Italia, Milan, Italy) is a patient-controlled analgesia (PCA) system approved in September 2015 by the European Commission for the management of acute…
- Conditions
- Postoperative Pain, Spinal Fusion, Spondylolisthesis, Lumbar Region, Sufentanil
- Trial name
- NCT03459404
- Testing
- Sufentanil NanoTab PCA System
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery
The present study is proposed to evaluate the efficacy and safety of single doses of Diclofenac HPBCD subcutaneous (s.c.) (25 mg/1 ml and 50 mg/1 ml) in the treatment of acute moderate-to-severe pain after dental impaction…
- Trial name
- NCT00942448
- Testing
- Diclofenac HPBCD
- Where
- 6 sites in Poland, United Kingdom
- Volunteers
- 306 people
- Sponsor
- IBSA Institut Biochimique SA
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Pain, Acute Pain
Optimal Management of Pain in Hospitalized Patients - Opioid Tolerant Populations.
Pain is a symptom that drives hospital admissions, and pain management is required by most patients during their hospital stay. Further, the use of medications such as opioids can lead to upward-spiraling doses, especially among…
- Conditions
- Pain, Acute Pain, Postoperative Pain
- Trial name
- NCT02470728
- Testing
- New Clinical Pathway
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Acute Postoperative Pain
Effects of tDCS and VNS on Postoperative Analgesia
This study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general…
- Trial name
- NCT06554067
- Testing
- Active transcranial direct current stimulation, Active vagus nerve stimulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postoperative Pain, Acute Pain
Two Bupivacaine Concentrations for Recto-Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy
Pain after laparoscopic cholecystectomy remains clinically relevant, and current recommendations favour multimodal, opioid-sparing analgesia including regional techniques.
- Conditions
- Postoperative Pain, Acute Pain, Cholelithiasis, Anesthesia
- Trial name
- NCT07841951
- Testing
- Bupivacaine 0.25% - recto-intercostal fascial plane block, Bupivacaine 0.125% - recto-intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Opioid Use, Arthropathy of Knee
RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use
This is a single-center, prospective, randomized, controlled study of the appliedVR RelieVRx headset in subjects undergoing Total Knee Arthroplasty (TKA).
- Conditions
- Opioid Use, Arthropathy of Knee, Pain, Postoperative
- Trial name
- NCT04010266
- Testing
- RelieVRx headset, multi-modality pain management
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- AppliedVR Inc.
Post op Pain
Phenotyping Acute Pain for Discovery Research and Directed Therapeutics
The goal of the current study is to combine existing and new tools for quantifying patient self-report to characterize changes in acute pain.
- Trial name
- NCT02322996
- Testing
- questionnaires
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- East Carolina University
Postoperative Pain, Acute
Serratus Posterior Superior Intercostal Plane Block
Background: Adequate pain control after video-assisted thoracoscopic surgery (VATS) remains a major clinical challenge. Traditional techniques such as thoracic epidural analgesia are effective but limited by potential…
- Trial name
- NCT07330479
- Testing
- Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block, Subcutaneous Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Gaziantep
Postoperative Acute Pain
Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy
A single-center, randomized, double-blind, placebo-controlled trial design will be adopted to investigate whether Anruikefon can significantly reduce the consumption of sufentanil via PCIA pumps within 48 hours postoperatively…
- Trial name
- NCT07801183
- Testing
- Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Post Operative Pain, Acute, Post-Op Complication
Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery
This study aims to figure out how small-bore pigtail catheter or large-bore chest tube for postoperative drainage impact on analgesic efficacy and actually enhance recovery postoperatively.
- Conditions
- Post Operative Pain, Acute, Post-Op Complication, Opioid Use, Unspecified, ERAS
- Trial name
- NCT06050551
- Testing
- uniportal VATS
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Pain Management
A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007)
Researchers are looking for new treatments for pain. While there are many approved treatments for pain, the treatments do not work well for everyone. People can also become addicted to certain pain medicines.
- Trial name
- NCT07862595
- Testing
- MK-6916, Hydrocodone/acetaminophen (HB/APAP), Rescue Medication
- Volunteers
- 380 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Myocardial Injury After Non-cardiac Surgery, Abdomen, Acute
Troponin I Level and Mortality in Acute Abdominal Surgery
The goal of this prospective cohort study is to estimate the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing acute high-risk abdominal surgery.
- Trial name
- NCT05933837
- Testing
- Troponin I
- Where
- Denmark
- Volunteers
- 341 people
- Sponsor
- Nordsjaellands Hospital
Pain, Postoperative, Breast Cancer
Postoperative Analgesia Impact of Narcotic Free Anesthesia
The first hypothesis of the study is that substituting fentanyl by esmolol and metoprolol during general anesthesia for patients undergoing mastectomy will result in less pain and less narcotic consumption in the recovery room.
- Conditions
- Pain, Postoperative, Breast Cancer, Postoperative Nausea and Vomiting
- Trial name
- PAINFree (NCT01544959)
- Testing
- fentanyl, beta-blocker (esmolol, metropolol)
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Université de Sherbrooke