Clinical trials: Acute Post-surgical Pain
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Chronic Pain, Acute Pain
Pain Predict Genetics
Pain is the most frequent cause of suffering and disability in society. Despite considerable involvement of genetic factors in pain sensation and sensitivity, the individual genes involved remain largely unidentified.
- Trial name
- PPG (NCT02383342)
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Radboud University Medical Center
Serratus Anterior Plane Block, Acute Pain
Combined SAPB in MICS
Minimally invasive cardiac surgery (MICS) has begun to be performed frequently in recent years. Compared to sternotomy, MISC reduces the risk of mediastinitis, leaves a more aesthetic scar, facilitates postoperative…
- Conditions
- Serratus Anterior Plane Block, Acute Pain, Postoperative Analgesia, Minimal Invasive Cardiac Surgery
- Trial name
- NCT06326320
- Testing
- Combined SAPB
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain, Pregabalin
Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects
The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.
- Conditions
- Postoperative Pain, Pregabalin, Spine Surgery, Adverse Reaction to Pregabalin
- Trial name
- NCT05478382
- Testing
- Pregabalin 25 MG
- Volunteers
- 132 people
- Sponsor
- Ajou University School of Medicine
Adenotonsillar Hypertrophy, Obstructive Sleep Apnea
Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy
Postoperative pain management in the pediatric patient undergoing tonsillectomy is challenging. Despite being used in many procedures for postoperative pain management, perioperative ketorolac usage in pediatric tonsillectomy…
- Conditions
- Adenotonsillar Hypertrophy, Obstructive Sleep Apnea, Sleep-Disordered Breathing, Acute Post Operative Pain
- Trial name
- NCT05074056
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Analgesia, Pain Management
Ultrasound-Guided Recto-Intercostal Fascial Plane Block in Laparoscopic Cholecystectomy
The aim of the study is to reduce postoperative pain by performing rectointercostal block in L/S cholecystectomy surgeries. Main goal is to provide well managed post-operative analgesia.
- Conditions
- Analgesia, Pain Management, Pain, Acute Post-Operative
- Trial name
- NCT07745972
- Testing
- Rectointercostal facial plane block using bupivacaine 0.25%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Acute Postoperative Pain in Urological Surgery, Pain Management in Postoperative Care (Including Opioid-Sparing Approaches)
Nudging to Promote the Use of Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief
This study aims to increase the use of transcutaneous electrical nerve stimulation (TENS) for acute postoperative pain relief. TENS, a non-pharmacological treatment using electrical impulses, can enhance pain relief, reduce…
- Trial name
- Nudging pain (NCT06696430)
- Testing
- Educational Intervention on TENS Usage, Nudging Intervention to Promote TENS Usage
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Pether Jildenstal
Internal Derangement of Hip, Acetabular Labrum Tear
Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain
The goal of the study is to evaluate via a prospective, blinded, randomized clinical trial, whether ultrasound-guided single femoral and lateral femoral cutaneous nerve blocks with ropivacaine 0.5% with epinephrine (1:200,000) as…
- Trial name
- NCT01997567
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rush University Medical Center
Thorax; Pain, Spine, With Radicular and Visceral Pain, Acute Post-thoracotomy Pain
Ultrasound Needle Transducer for Regional Anesthesia Validation Study
To validate the efficacy of miniaturized ultrasound needle transducer as the primary guide for thoracic regional anesthesia.
- Conditions
- Thorax; Pain, Spine, With Radicular and Visceral Pain, Acute Post-thoracotomy Pain, Pain, Postoperative, Ultrasound Therapy; Complications
- Trial name
- NCT04726930
- Testing
- Intercostal nerve blocks, Paravertebral block
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Pain, Chronic Pain
Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery
The aim of the study is to evaluate efficacy and safety of long term (14 days) wound infusion with levobupivacaine in patients with breast cancer undergoing mastectomy with immediate breast reconstruction: this is a double blind…
- Conditions
- Acute Pain, Chronic Pain, Wound Infusion, Mastectomy
- Trial name
- NCT02035904
- Testing
- Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia), saline, Levobupivacaine continuous infusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pain, Postoperative, Pain, Acute
Sensory Assessment and Regression Rate of Bilateral External Oblique Intercostal Block and m-TAPA Block
External oblique and m-tapa blocks are routinely performed on patients undergoing laparoscopic cholecystectomy in our clinic. In this study, sensory block and regression rates will be investigated in patients who underwent block.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain
- Trial name
- NCT05744544
- Testing
- External Oblique Block, m-TAPA block
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Samsun University
Pain
From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy
Chronic Pain is a wellknown complication after cholecystectomy. Intensity of the pain in the first week after the operation is a predictive factor for the development of chronic pain, but it is unknown whether the risk is more…
- Trial name
- FACTS1 (NCT01553253)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Pain Management
MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery
This study seeks to define what constitutes an MCID and a PASS in patients undergoing a variety of elective major orthopedic surgery.
- Trial name
- NCT04811209
- Testing
- 1.Baseline Measurements Before Surgery, 2.Intraoperative Anesthetic Management, 3.Postoperative Analgesic Management
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Acute Abdomen, Abdominal Trauma
Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Emergency Laparotomy
The goal of this clinical trial is to test the safety and effectiveness of the ERAS protocols compared to a conventional care protocols in patients who received emergency laparotomy.
- Conditions
- Acute Abdomen, Abdominal Trauma, Emergency Surgery
- Trial name
- ERAS (NCT06182488)
- Testing
- ERAS protocols, Conventional protocols
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University
Cardiac Anaesthesia, Chronic Pain
Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery
The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing…
- Conditions
- Cardiac Anaesthesia, Chronic Pain, Post Operative Pain, Chronic, Post Operative Pain, Acute
- Trial name
- NCT07490457
- Testing
- Ketamine group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Postoperative Pain
COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY
The most important determinant of the recovery in abdominal surgery is postoperative pain. Postoperative pain can be explained by 2 pathways connected to the peritoneum; The first is the parietal peritoneum, whose innervation is…
- Trial name
- APPENDECTOMY (NCT03790020)
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Labor Pain, Pain, Postoperative
Spinal Analgesia as Fast Track Painless Labor
The purpose of this prospective, randomized, and controlled trial was to compare the efficacy of single-shot spinal analgesia to typical conventional treatments (continuous epidural analgesia and spinal-epidural combination) in…
- Conditions
- Labor Pain, Pain, Postoperative, Pain, Acute
- Trial name
- NCT05271760
- Testing
- Single-shot spinal analgesia, Continuous epidural analgesia, Combined spinal-epidural analgesia
- Where
- Saudi Arabia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Postoperative Pain, Acute
Combined Ketorolac Bupivacaine Versus Bupivacaine Alone for TAP Block in Children Undergoing Lower Abdominal Surgeries
Control of of pain in children is fundamental. TAP block is associated with less side effects compared with other neuraxial techniques especially when done under ultrasound guidance.
- Trial name
- NCT06267820
- Testing
- Bupivacain, Ketorolac
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Breast Cancer
Paravertebral Block and Reduction in Opioid Consumption After Mastectomy
This prospective randomized study evaluates the efficacy of paravertebral block in reducing opioid consumption during mastectomy and its impact on acute and chronic postoperative pain.
- Trial name
- BPV-MAST (NCT07817797)
- Testing
- Paravertebral Block, Multimodal Analgesia
- Where
- Tunisia
- Volunteers
- 40 people
- Sponsor
- University Tunis El Manar