Clinical trials: Acute Post-surgical Pain
Acute Postoperative Pain, Surgery
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty.
- Trial name
- NCT06784882
- Testing
- continuous peripheral nerve block with OnQ pump, single injection nerve block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Postoperative Pain, Acute, Lung Cancer
Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine
This randomized controlled trial evaluates the analgesic effects of liposomal bupivacaine compared to bupivacaine hydrochloride in intercostal nerve block for patients undergoing thoracoscopic lung surgery.
- Trial name
- NCT07134660
- Testing
- Liposomal Bupivacaine intercostal nerve block, Bupivacaine Hydrochloride intercostal nerve block, Standard Postoperative Analgesia
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Hip Arthroplasty, Postoperative Pain
DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery
This randomized, double-blind clinical trial aims to compare the effectiveness of the Deep Iliacus Plane Block (DIPB) and the Suprainguinal Fascia Iliaca Block (SIFIB) for postoperative pain control in patients undergoing primary…
- Conditions
- Hip Arthroplasty, Postoperative Pain, Regional Anesthesia, Acute Postoperative Pain
- Trial name
- NCT07452120
- Testing
- Suprainguinal Fascia Iliaca Block, Deep Iliacus Plane Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sivas Numune Hospital
Thoracic Surgery, Video-Assisted
Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Thoracic Surgery, Video-Assisted, Cryotherapy Effect, Paravertebral Block
- Trial name
- CRYO-VATS (NCT05896150)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lumbar Disc Herniation, Lumbar Disc Surgery
Effectiveness of Virtual Reality-Assisted Physical Therapy in the Acute Phase After Lumbar Disc Surgery
The goal of this clinical trial is to evaluate the effectiveness of virtual reality-assisted physical therapy in the acute postoperative period after lumbar disc surgery.
- Trial name
- NCT07204197
- Testing
- Virtual Reality-Assisted Physical Therapy, Conventional Physical Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Postoperative Pain, Chest Pain
Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery
Inadequate pain control after coronary artery bypass graft surgery increases mortality and results in a higher incidence of persistent poststernotomy pain syndrome.
- Conditions
- Postoperative Pain, Chest Pain, Coronary Artery Bypass, Sternotomy
- Trial name
- NCT04591119
- Testing
- Transversus Thoracic Muscle Plane Block, Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Muğla Sıtkı Koçman University
Acute Postoperative Pain
Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA
Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target-controlled infusion compared to conventional patient-controlled analgesia with morphine after elective cardiac…
- Trial name
- NCT02483221
- Testing
- Hydromorphone, Morphine
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pain, Acute
Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction
This Phase III study will compare the efficacy and tolerability of a Fixed Dose Combination of Etodolac + Cyclobenzaprine versus the isolated drugs in postoperative pain control after impacted third molar extraction.
- Trial name
- FDCETCB-III (NCT03127592)
- Testing
- Fixed Dose Combination, Etodolac, Cyclobenzaprine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Apsen Farmaceutica S.A.
Postoperative Pain, Acute
Erector Spinae Plane Block Versus Iliohypogastric/Ilioinguinal Nerve Block for Post-Hysterctomy Pain Relief
The goal of this clinical trial is to compare the degree of pain relief between two techniques of regional anesthesia given to ladies undergoing hysterectomy under general anesthesia.
- Trial name
- NCT07113600
- Testing
- Nerve Block
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Serratus Anterior Plane Block, Pain, Postoperative
Effect of Different Local Anesthetic Volumes of Serratus Anterior Plan Block After Video-Assisted Thoracoscopic Surgery
Video-assisted thoracic surgery (VATS) has become a common procedure in thoracic surgery. Severe postoperative pain may be encountered in patients undergoing VATS.
- Conditions
- Serratus Anterior Plane Block, Pain, Postoperative, Thoracic Surgery, Video-Assisted, Local Anesthetic
- Trial name
- NCT05255536
- Testing
- Serratus Anterior Plan Block with 20 ml, Serratus Anterior Plan Block with 30 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
Environmental Game After Appendicitis Surgery
This study was conducted to determine the effect of environmental play and mobilization on fear and pain levels of children aged 6-12 years who had acute appendicitis surgery.
- Trial name
- NCT05104021
- Testing
- game
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Okan University
Pain, Postoperative
Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.
The aim of this study was to evaluate the effect of intraoperative methadone on postoperative analgesic requirements, pain scores and patient satisfaction in comparison to standard intraoperative pain control with fentanyl.
- Trial name
- NCT03529032
- Testing
- Methadone
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Kantonsspital Baden
Hip Arthroplasty, Total, Post Operative Pain, Acute
Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty
Hip replacement surgery is one of the most commonly performed surgical procedures in France, with approximately 150,000 procedures per year.
- Conditions
- Hip Arthroplasty, Total, Post Operative Pain, Acute, Nerve Block
- Trial name
- SOSBIFSI (NCT06982625)
- Testing
- Ultrasound guided supra inguinal fascia iliaca block, Surgical and anesthetic protocol
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Mutualiste Montsouris
Delirium, Pain
Pregabalin in the Prevention of Postoperative Delirium and Pain
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves…
- Trial name
- NCT00819988
- Testing
- Pregabalin, Sugar pill
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
Anesthesia, Acute Pain
Comparative Effects of Ciprofol and Propofol on Pain Intensity on the First Day After Surgery: a Retrospective, Propensity Score Matched, Cohort Study
Data intelligence platform was widely used to facilitate the process of clinical research. However, a platform that integrates natural language processing (NLP) and machine learning (ML) algorithms has not been reported in…
- Conditions
- Anesthesia, Acute Pain, Risk Reduction
- Trial name
- NCT06020469
- Where
- China
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Guangdong Second Provincial General Hospital
Pain, Postoperative, Complication, Postoperative
Optimizing Acute Post-Operative Dental Pain Management Using New Health Information Technology
The investigators seek to implement a dental patient reported outcomes system using mobile phone and text messaging to target the over-reliance on pre-emptively prescribed opioids by dental providers.
- Trial name
- AHRQPRO (NCT03881891)
- Testing
- Follow-app intervention arm
- Where
- 2 sites in United States
- Volunteers
- 1,525 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Pain, Acute, Ventral Hernia
Study Exploring the Effect of Music on Pain After Ventral Hernia Surgery
The purpose of this study is to assess whether listening to music during surgery has an effect on pain or anxiety after surgery.
- Conditions
- Postoperative Pain, Acute, Ventral Hernia, Hernia Abdominal Wall, Surgery
- Trial name
- NCT05374096
- Testing
- Patient-Chosen Music
- Where
- United States
- Volunteers
- 321 people
- Sponsor
- The Cleveland Clinic
Acute Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
- Trial name
- NCT06887959
- Testing
- Suzetrigine
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Vertex Pharmaceuticals Incorporated