Clinical trials: Acute Post-surgical Pain
Postoperative Pain, Sternotomy Pain
Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy
This study aims to compare the effectiveness of two regional anesthesia techniques in managing pain for participants undergoing cardiac surgery via sternotomy.
- Conditions
- Postoperative Pain, Sternotomy Pain, Acute Pain, Cardiac Surgery
- Trial name
- NCT07472296
- Testing
- Erector spinae plane block (ESPB), Superficial Parasternal Intercostal Plane Block (SPIPB), Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uludag University
Acute Abdomen
Upper Gastrointestinal Perforations: a Nationwide Registry-based Study
The primary aim of this project is to increase the knowledge about how perforations in the esophagus, stomach and small intestine are treated on a national level.
- Trial name
- NCT06154603
- Testing
- Surgical treatment type
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Stockholm
Pediatric Surgical Patients, Preemptive Epidural Analgesia
The Impact of Preemptive Epidural Analgesia on Acute Postoperative Pain in Pediatric Orthopedic Surgery
Management of postoperative pain is critical in the pediatric patients, however, safe and effective analgesia for pediatric surgical patients remains a challenge.
- Trial name
- NCT02813018
- Testing
- 0.2 ml/kg of 0.2% ropivacaine, 0.2mg/kg of Normal Saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Cholecystitis
Harmonic in Laparoscopic Cholecystectomy for Acute Cholecystitis
In the developmental stage of laparoscopic cholecystectomy it was considered 'unsafe' or 'technically difficult' to perform laparoscopic cholecystectomy for acute cholecystitis.
- Trial name
- HAC (NCT00746850)
- Testing
- early LC within 72 hours after the diagnosis with H (Harmonic), early LC within 72 hours after the diagnosis with MD (Monopolar Diathermy)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- University of Bologna
Postoperative Pain, Acute
Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries
Tourniquet, a compressing device, otherwise its use in intravenous regional anesthesia, is commonly used in particular orthopedic surgeries.
- Trial name
- K-IVRAg (NCT05543785)
- Testing
- Ketorolac, Control
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Pain, Acute
Oral Steroid in Controlling Pain After TKA
To compare efficacy of oral steroid in controlling pain after TKA
- Trial name
- NCT04244695
- Testing
- Dexamethasone Oral
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Thammasat University
Breast Surgery
ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery
The block (ESP or PVB) will be performed preoperatively in the recovery room under standard monitoring. After setting a peripheral venous access, patient will be installed on lateral decubitus position on the opposite side of the…
- Trial name
- ER-One (NCT04827030)
- Testing
- Ropivacaïne Hydrochloride by Erector Spinae block, Ropivacaïne Hydrochloride by Paravertebral block
- Where
- 5 sites in France
- Volunteers
- 292 people
- Sponsor
- Institut Curie
Cholecystitis/Cholelithiasis
Effects of Intravenous Ibuprofen on Acute Pain After Laparoscopic Cholecystectomy
This clinical trial is a medical intervention study to evaluate the necessity and effectiveness of intravenous ibupropan for postoperative acute pain relief after laparoscopic cholecystectomy in benign gallbladder disease.
- Trial name
- NCT05676892
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul St. Mary's Hospital
Mastectomy, Pain, Chronic
Affecting Factors for Chronic Pain After Mastectomy
Chronic post-mastectomy pain (CPMP) is a significant issue affecting many women after mastectomy. Factors like age, treatment type, and pre-surgery pain can increase the risk of developing this condition.
- Conditions
- Mastectomy, Pain, Chronic, Pain, Acute, Breast Surgery
- Trial name
- CPMP (NCT06592053)
- Testing
- Breast Cancer Surgery Pain
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ankara Etlik City Hospital
Pain, Post-operative, Third Molar
Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction
This is a prospective randomized clinical trial that will investigate which post-operative medications in conjunction with a multimodal analgesia approach can most effectively control post-operative pain and reduce opioid…
- Conditions
- Pain, Post-operative, Third Molar, Oral Surgery, Pain, Acute
- Trial name
- NCT06484439
- Testing
- Ketorolac, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Appendectomy, Pain, Postoperative
Comparison of Outcomes After Laparoscopic Versus Open Appendectomy in Acute Appendicitis
A comparison study was performed between laparoscopic appendectomy and open appendectomy in acute setting in tertiary hospital to access the outcome of postoperative pain and hospital stay.
- Conditions
- Appendectomy, Pain, Postoperative, Length of Stay
- Trial name
- NCT03947372
- Testing
- Appendectomy
- Where
- Pakistan
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Services Hospital, Lahore
Chronic Post-thoracotomy Pain, Neuropathic Pain
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
This study aims to evaluate the efficacy of ultrasound-guided Serratus Posterior Superior (SPS) block compared to surgeon-administered intercostal blockade in preventing chronic pain at 3, 6, and 12 months following…
- Conditions
- Chronic Post-thoracotomy Pain, Neuropathic Pain, Postoperative Pain, Acute
- Trial name
- NCT07436806
- Testing
- SPS block, Surgical Intercostal Blockade.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Pain, Postoperative
Comparison of PECS II Block and Combined Serratus Anterior Plane Block to Reduce Acute Pain After Mastectomy
In this study, PECS II block or CSAB will be applied to patients who have had a modified radical mastectomy under general anesthesia for postoperative pain relief by using 30 ml of 0.25% bupivacaine .All patients will receive…
- Trial name
- NCT05961735
- Testing
- PECS II Block, Combined Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Pain, Postoperative
Cortical Modulation of Acute Post-thoracotomy Pain With Transcranial Direct Current Stimulation
The primary objective of this single center, prospective, randomized, double blind clinical trial is to evaluate the effectiveness of anodal transcranial direct current stimulation (tDCS) combined with patient controlled…
- Trial name
- CMAPTPtDCS (NCT03005548)
- Testing
- Transcranial direct current stimulation, Morphine
- Where
- Serbia
- Volunteers
- 62 people
- Sponsor
- Military Medical Academy, Belgrade, Serbia
Breast Cancer, Postoperative Pain, Acute
Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. RIB has been reported to be successful in attenuating acute pain following breast surgeries.
- Conditions
- Breast Cancer, Postoperative Pain, Acute, Postoperative Pain, Chronic, Neuropathic Pain
- Trial name
- NCT06019325
- Testing
- RIB
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Muğla Sıtkı Koçman University
Pain Postoperative, Analgesia
Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain
This is a single-center, randomized, double-blind, placebo-controlled, parallel-group proof-of-concept study to evaluate the analgesic efficacy and safety of omega-3 fatty acids as an adjunct to morphine for acute postoperative…
- Trial name
- O3MORPH (NCT07657468)
- Testing
- Omega-3 fatty acids + Morphine group
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of La Rioja
Post Operative Pain, Acute, Irreversible Pulpitis
To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless
The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years.
- Trial name
- NCT07266974
- Testing
- AH-Plus Epoxy Resin Sealer, bioceramic sealer
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jaweria Gul Keyani
Postoperative Pain
Duloxetine vs Pregabalin for Thoracotomy Pain
This study investigates the effects of preoperative use of oral combination of duloxetine and Pregabalin in comparison with preoperative oral Pregabalin only in treatment of acute postoperative and prevention of chronic pain…
- Trial name
- NCT04782310
- Testing
- Pregabalin, Duloxetine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Paravertebral Peripheral Nerve Block, Acute Pain Management
Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control
The overall purpose of this research study is to compare the effectiveness of ultrasound assisted paravertebral block placement versus traditional "blind" technique for postoperative analgesia following thoracotomy or visually…
- Trial name
- NCT01949480
- Testing
- Thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Pittsburgh
Pain, Pain, Postoperative
Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain
To develop and refine a technology based treatment protocol for preoperative education and training and postoperative care in children and adolescents undergoing surgery.
- Conditions
- Pain, Pain, Postoperative, Pain, Acute, Surgery
- Trial name
- NCT04943874
- Testing
- Technology Based Intervention Group 1, Technology Based Intervention Group 2
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Vanessa Olbrecht