Clinical trials: Acute Post-surgical Pain
Regional Anesthesia, Postoperative Pain, Acute
Caudal Block and Transversus Abdominis Plane Block in Pediatric Inguinal Hernia Repair
Pediatric inguinal hernia repair (IHR) candidates experiences ordinarily mild to moderate pain, rarely severe pain in the postoperative period.
- Trial name
- NCT05286190
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Nausea, Vomiting
Effect of Intravenous Patient-controlled Analgesia (IV-PCA) With Fentanyl in Adults for Acute Postoperative Pain Control
In this retrospective study, the investigators examined incidence and risk factors of postoperative nausea and vomiting (PONV) in patients with fentanyl-based intravenous patient-controlled analgesia (IV-PCA).
- Trial name
- NCT01527890
- Testing
- Fentanyl
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Yonsei University
Pain, Acute Post-Operative, Nausea and Vomiting, Postoperative
Catheter Redosing of Autonomic Neural Blockade After Sleeve Gastrectomy
Postoperative visceral pain and autonomic symptoms after laparoscopic sleeve gastrectomy may reappear earlier in selected high-risk patients despite standard intraoperative autonomic neural blockade (ANB).
- Trial name
- NCT07655908
- Testing
- Bupivacaine 0.5% and Dexamethasone via Temporary Catheter
- Volunteers
- 30 people
- Sponsor
- Universidad Simón Bolívar
Postoperative Pain, Chronic Pain
Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
To assess the effects of prolonged preoperative gabapentin treatment (10 days) on chronic pain after thoracotomy.
- Trial name
- GABATHOMIE (NCT03158376)
- Testing
- Gabapentin
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Lille
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Post-operative Pain Following Caesarean Section
Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
Background: Multimodal analgesia; a combination of opioid and non-opioid analgesics, for management of acute post-operative pain significantly reduces the incidence of adverse effects associated with liberal post-operative opioid…
- Trial name
- OFAAPPCS (NCT04539249)
- Testing
- Magnesium sulphate, Pentazocine
- Where
- Nigeria
- Volunteers
- 324 people
- Sponsor
- Olakunle Ifeoluwa Makinde
Opioid-use Disorder, Pain, Acute
Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use
The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced dose buprenorphine/naloxone prior to…
- Conditions
- Opioid-use Disorder, Pain, Acute, Surgery
- Trial name
- NCT03266445
- Testing
- buprenorphine/naloxone
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Pain, Postoperative Pain
Study of QL Analgesic Response and Extent
A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process.
- Conditions
- Acute Pain, Postoperative Pain, Regional Anesthesia Block
- Trial name
- SQUARE (NCT07566312)
- Testing
- Quadratus Lumborum with 1.5% Lidocaine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Postoperative Pain, Acute Cholecystitis
USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (LC) can cause moderate-to-severe postoperative pain from visceral, referred shoulder, and incisional sources. Multimodal analgesia is recommended, but opioids carry significant side effects.
- Conditions
- Postoperative Pain, Acute Cholecystitis, Cholelithiasis, Postoperative Nausea and Vomiting
- Trial name
- NCT07552701
- Testing
- M-TAPA Group, RIFPB Group
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Hitit University
Lung Diseases
The Effectiveness of Acupressure for Managing Postoperative Pain and Anxiety in Patients With Thoracoscopic Surgery
The purpose of this study is to explore the effectiveness of acupressure for managing postoperative pain, anxiety, analgesia consumption, early ambulation, and comfort in patients with thoracoscopic surgery.
- Trial name
- NCT04595253
- Testing
- acupressure
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei-Fen Ma
Head and Neck Cancer, Acute Pain
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Patient satisfaction with healthcare is increasingly being utilized as a metric to reflect provider and hospital quality of care.
- Conditions
- Head and Neck Cancer, Acute Pain, Postoperative Pain
- Trial name
- GABA (NCT02926573)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Postoperative Pain, Acute
Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures
The goal of this clinical trial is to compare the analgesic efficacy of adding dexmedetomidine versus ibuprofen to bupivacaine for intraperitoneal instillation after laparoscopic gynecological procedures.
- Trial name
- NCT06046105
- Testing
- Administering intraperitoneal bupivacaine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Dexmedetomidine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Ibuprofen for pain control after laparoscopic gynecological procedures
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Distal Radius Fractures
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people…
- Trial name
- TRADR (NCT06384456)
- Testing
- Topical TRanexamic Acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Acute Pain
Ketamine Versus Morphine Change Pain Profile
The aim of this study is to evaluate the efficacy of intravenous low dose ketamine infusion versus morphine infusion analgesia for pain reduction in Abdominoplasty surgery
- Trial name
- NCT03664622
- Testing
- Ketamine, Morphine
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Pain, Postoperative Pain
PENG Block Plus Lateral Femoral Cutaneous Nerve Block for Posterolateral-approached Total Hip Arthroplasty
This study aims to analyze the effect of Pericapsular Nerve Group (PENG) Block combined with lateral femoral cutaneous nerve block vs.
- Conditions
- Pain, Postoperative Pain, Acute Pain, Analgesia
- Trial name
- PENG-FLAT (NCT05432011)
- Testing
- PENG Block, Lateral Femoral Cutaneous Nerve Block, Wound Infiltration
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Campus Bio-Medico University
Orthopaedic Surgery
Remote Controlled Analgesia on Patient Experience
The main objective of this study is to compare the efficacy of continuous nerve blocks with single injection in terms of perioperative patient satisfaction after scheduled orthopedic ambulatory surgery.
- Trial name
- R-CAPE (NCT02720965)
- Testing
- Remote-controlled perineural local anesthetics delivery
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Acute Pain
A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries
The purpose of this study to evaluate the effectiveness, safety, and tolerability of SUZ as part of multimodal therapy (MMT) in treating acute postoperative pain.
- Trial name
- NCT06887972
- Testing
- Suzetrigine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
Double-Blind, Randomized Study Of The Analgesic Efficacy And Safety Of Valdecoxib 20 Mg Daily And Valdecoxib 20 Mg Twice Daily Compared To Placebo For Management Of Acute Postsurgical Pain In Anterior Cruciate Ligament (ACL) Reconstruction
The primary objective was to evaluate the analgesic efficacy of valdecoxib 20 mg daily and valdecoxib 20 mg twice daily compared with placebo in outpatients with moderate-severe pain after arthroscopic anterior cruciate ligament…
- Trial name
- NCT00650039
- Testing
- valdecoxib
- Where
- 81 sites in United States, Canada
- Volunteers
- 488 people
- Sponsor
- Pfizer
Pain, Acute, Hip Arthropathy
Safety of Ibuprofen After Major Orthopaedic Surgeries
Safety of an eight-day treatment with ibuprofen after primary hip and knee arthroplasties.
- Conditions
- Pain, Acute, Hip Arthropathy, Knee Arthropathy, Safety Issues
- Trial name
- PERISAFE (NCT05575700)
- Testing
- Ibuprofen
- Where
- 11 sites in Denmark
- Volunteers
- 2,904 people
- Sponsor
- Naestved Hospital
Hip Fractures, Acute Post Operative Pain
PENG vs SIFI Block for Positioning Pain During Spinal Anesthesia
This study aims to compare the effectiveness of preoperative ultrasound-guided suprainguinal fascia iliaca compartment block (SFICB) and pericapsular nerve group block (PENG) in preventing positioning pain during spinal…
- Conditions
- Hip Fractures, Acute Post Operative Pain, Nerve Block, Spinal Anesthesia
- Trial name
- NCT05549011
- Testing
- PENG Block, SIFI compartment block, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization