Clinical trials: Acute Respiratory Distress Syndrome (ARDS)
ARDS, Prone Position
Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography
determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography
- Conditions
- ARDS, Prone Position, Electrical Impedance Tomography
- Trial name
- NCT04725227
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Pressure Ulcer, Respiratory Distress Syndrome, Acute
Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study
Prone position (PP) is standard of care for mechanically ventilated patients with severe acute respiratory distress syndrome in the intensive care unit (ICU). Recommendations suggest PP durations of at least 16 hours.
- Conditions
- Pressure Ulcer, Respiratory Distress Syndrome, Acute, Hypoxemic Respiratory Failure, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05124197
- Testing
- prone position
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Hôpital Louis Mourier
ARDS, Human, COVID
Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib in the treatment of patients with COVID-19 severe pneumonia.
- Trial name
- RuXoCoil (NCT04359290)
- Testing
- Ruxolitinib administration
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Philipps University Marburg
Lung Collapse, Lung Diseases
The Accuracy of Pediatric Air Test as a Non-invasive Atelectasis Diagnostic Tool
HYPOTHESIS: During anesthetic pre-oxygenation with high FiO2, pulmonary atelectasis occur, especially in patients < 6 years old, where FRC and pulmonary closing volume may overlap.
- Conditions
- Lung Collapse, Lung Diseases, Atelectasis, Atelectasis Without Respiratory Distress Syndrome
- Trial name
- NCT04506203
- Testing
- Air test
- Where
- 3 sites in Argentina, Spain
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
ARDS (Acute Respiratory Distress Syndrome)
Effect of EIT-guided PEEP in ARDS Patients
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury.
- Trial name
- NCT06990477
- Testing
- EIT-guided PEEP
- Where
- 17 sites in China, South Korea and 1 more
- Volunteers
- 2,400 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome (ARDS)
Surviving ARDS: The Influence of Quality of Care and Individual Patient Characteristics on Quality of Life
The purpose of the DACAPO study ("Surviving ARDS: the influence of quality of care and individual patient characteristics on quality of life") is to investigate the role of quality of care and individual patient characteristics…
- Trial name
- DACAPO (NCT02637011)
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Regensburg
Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2
Evaluation of Sedation in COVID-19 ARDS
This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients.
- Conditions
- Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2, Hypnotics and Sedatives, Pulmonary Ventilation
- Trial name
- NCT04667936
- Testing
- Treatment group
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Goethe University
Acute Respiratory Distress Syndrome
Safety, Tolerability, and Efficacy of MatriPlax in Subjects With Acute Respiratory Distress Syndrome
The goal of this clinical trial is to explore the safety, tolerability, and efficacy in study intervention, MatriPlax, in subjects with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05886985
- Testing
- MatriPlax
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- BioSpring Medical Co., Ltd
ARDS
The Effect of Caloric Supplement in the Clinical Outcomes in Acute Lung Injury Patients
The optimal amount caloric intake were still controversy in critically ill patients in literature. There were no significant outcome difference with different caloric intake in acute lung injury patients.
- Trial name
- NCT04262440
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taichung Veterans General Hospital
Developing Acute Respiratory Distress Syndrome
Advanced Respiratory Monitoring for Safer Mechanical Ventilation in Patients Without Respiratory Failure
Patients admitted to the intensive care unit (ICU) and mechanically ventilated for reasons other than acute respiratory failure, such as coma, trauma, or sepsis, are at risk of developing acute respiratory distress syndrome…
- Trial name
- ADAPT (NCT07686315)
- Testing
- Advanced Non-Invasive Respiratory Monitoring
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Acute Respiratory Distress Syndrome (ARDS)
To Evaluate The Safety and Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
To evaluate the efficacy, safety and tolerability of STSA-1002 injection in patients with acute respiratory distress syndrome
- Trial name
- NCT07208591
- Testing
- STSA-1002 injection
- Where
- 15 sites in China
- Volunteers
- 406 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Acute Respiratory Distress Syndrome
Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end…
- Trial name
- NCT03946189
- Testing
- Obtaining arterial blood gases
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- American University of Beirut Medical Center
Median Nerve Entrapement
Large Scale ICU Data Sharing for 1000 Critically Ill Patients With Severe Acute Respiratory Distress Syndrome Coronavirus (SARS.COV19) in Three Distinct Isolation Centers
Cohort study of patients with severe respiratory distress syndrome coronavirus2 in three different isolation hospitals recording data about outcome.
- Trial name
- NCT04779268
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- Minia University
Acute Respiratory Distress Syndrome (ARDS)
Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with a diffuse, inflammatory form of lung injury, causing pulmonary infiltration and respiratory failure leading to poor oxygenation.
- Trial name
- NCT05241067
- Testing
- Normal Saline, Centhaquine
- Volunteers
- 80 people
- Sponsor
- Pharmazz, Inc.
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia
The purpose of this study is to use forced oscillometry technique (FOT) to measure pulmonary mechanics and function in in term infants and premature infants with bronchopulmonary dysplasia (BPD)
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- NCT04270045
- Testing
- Non-invasive forced airway oscillometry
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Winston Manimtim
ARDS
Driving Pressure as a Predictor of Mortality in Acute Respiratory Distress Syndrome Patients
The aim of this study is to make analysis of potentially modifiable factors contributing to outcome of mechanically ventilated ARDS adult patient receiving lung protective strategy.
- Trial name
- NCT04778228
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Assiut University
Pulmonary Alveolar Proteinosis, COPD
Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection
COVID-19 Viral Global Pandemic resulting in post-infection pulmonary damage, including Fibrotic Lung Disease due to inflammatory and reactive protein secretions damaging pulmonary alveolar structure and functionality.
- Conditions
- Pulmonary Alveolar Proteinosis, COPD, Idiopathic Pulmonary Fibrosis, Viral Pneumonia
- Trial name
- GARM-COVID19 (NCT04326036)
- Testing
- Microcannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF), Centricyte 1000, IV Deployment Of cSVF In Sterile Normal Saline IV Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Black Tie Medical, Inc.
ARDS (Acute Respiratory Distress Syndrome)
Lung EIT Image Guide Ventilation in ARDS
The goal of this multi-center randomized controlled clinical trial is to learn if an individualized, bedside electrical impedance tomography (EIT)-guided ventilation strategy (including EIT-guided prone positioning and PEEP…
- Trial name
- NCT07309783
- Testing
- Recruitment maneuver and PEEP setting guided by EIT, PEEP setting according to routine practice, Prone positioning guided by EIT
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
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